|
Candidiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previous studies showed a requirement for <i>Candida</i> biofilm formation on both palate and dentures in infection and identified fungal morphogenic transcription factors, Efg1 and Bcr1, as key players in DS pathogenesis.While both <i>C. albicans</i> and <i>Candida glabrata</i> are frequently coisolated in mucosal candidiasis, a pathogenic role for <i>C. glabrata</i> in DS remains unknown.
|
30944214 |
2019 |
|
Adenocarcinoma of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results</b>: High levels of WISP1 correlated with BCR-free survival in prostate adenocarcinoma and overall survival in primary melanoma, low-grade glioma, and kidney papillary cell carcinoma.
|
31069142 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, our findings support the antitumor potential of quinoline-chalcone derivatives for NSCLC and CML by inhibiting the PI3K/Akt/mTOR pathway.
|
30428415 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen.
|
31150624 |
2019 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings strongly suggest PHL as a potent therapeutic agent in treating PD.
|
31251998 |
2019 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This review explores the mechanisms behind cancer progression of these BCR oncogenic fusion proteins, comparing their similarities and differences, examining the significance of BCR as a partner gene, and discussing current treatment options for these translocation-induced hematopoietic malignancies.
|
31105873 |
2019 |
|
Myelofibrosis due to another disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to elucidate patterns of disease transformation to secondary myelofibrosis (SMF) or secondary acute myeloid leukemia (SAML) and the development of second primary malignancies in South Korean patients with BCR-ABL1-negative myeloproliferative neoplasms (MPNs).
|
31765478 |
2019 |
|
Impaired glucose tolerance
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The DIO models took several months to become obese, exhibited less severe hyperglycaemia and glucose intolerance, while glycation products were not significantly different between these groups (with the exception of furosine in liver and CML in lungs).
|
30467969 |
2019 |
|
Prostate cancer recurrent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Five patients with PCa and BCR, following radical prostatectomy, underwent 68Ga-PSMA PET/CT.
|
30901173 |
2019 |
|
secondary acute myeloid leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to elucidate patterns of disease transformation to secondary myelofibrosis (SMF) or secondary acute myeloid leukemia (SAML) and the development of second primary malignancies in South Korean patients with BCR-ABL1-negative myeloproliferative neoplasms (MPNs).
|
31765478 |
2019 |
|
HODGKIN'S AND NON-HODGKIN'S LYMPHOMA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our findings showed BMI, and BMI in early adulthood (aged 18-21 years) is associated with the risk of Hodgkin's and non-Hodgkin's lymphoma (HL and NHL), diffuse large beta-cell lymphoma (DLBCL), Leukaemia including acute and chronic myeloid lymphoma (AML and CML), and chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM).
|
30753270 |
2019 |
|
Gastrointestinal mucositis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An 11-year-old male patient with the deletion of <i>IKZF1</i> (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(<i>BCR-ABL1</i>) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate.
|
31607921 |
2019 |
|
CNS metastases
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
On the whole, these results provide an approach for addressing the mechanisms of BCR‑ABL1+ B‑ALL with CNS metastasis and may guide the development of novel therapeutic strategies.
|
31173268 |
2019 |
|
Hormone refractory prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
We set the starting point at the timing of BCR, and the endpoints were development to castration-resistant prostate cancer (CRPC) and cancer-specific death.
|
31559475 |
2019 |
|
Primary Cutaneous Follicle Center Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Similar to FL but in contrast to primary cutaneous diffuse large B-cell lymphoma, leg-type, BCR genes of 15 PCFCLs (83%) had acquired N-linked glycosylation motifs.
|
31042459 |
2019 |
|
Severe Aplastic Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sixteen patients (76.2%) were diagnosed with ALL and the rest individually with AML, CML, T-lymphoma, Burkitt lymphoma, and severe aplastic anemia.
|
31521834 |
2019 |
|
Thrombotic Microangiopathies
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib.
|
30692122 |
2019 |
|
CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these data show that the BCR GEF domain affects phenotypes associated with progression of SCLL through suppression of RHOA signaling.
|
30413411 |
2019 |
|
Infant Acute Undifferentiated Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of the total 631 cases, 52.9% (n=334) were acute lymphoblastic leukemia (ALL), 43.9% (n=277) acute myeloid leukemia (AML), 2.2% (n=14) mixed phenotypic acute leukemia (MPAL), 0.5% (n=3) acute undifferentiated leukemia (AUL) and 0.5% (n=3) chronic myeloid leukemia in blast crisis (CML-BC).
|
30858955 |
2019 |
|
Hyperleukocytosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Leukocytapheresis procedures were performed in 192 leukemia patients (including acute myeloid leukemia [AML], acute lymphoblastic leukemia [ALL], and chronic myeloid leukemia [CML]) with hyperleukocytosis between January and December 2016.
|
31829470 |
2019 |
|
IgE-mediated food allergy
|
0.010 |
Biomarker
|
disease |
BEFREE |
CML) than that in the cases of glucose and maltose; therefore, maltotriose could be applied to desensitize TM-induced food allergy through glycation, and this could be a potential immunotherapy for shrimp allergy patients.
|
31580362 |
2019 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that Psen1 functions as a scaffold of the BCR-CK2α-p65 complex and that this signaling cascade could be a novel therapeutic target for various chronic inflammation conditions, including those in Alzheimer disease.
|
30201812 |
2018 |
|
IGA Glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present results revealed that the BCR/TCR CDR3 clones were expressed at very low frequencies, and the composition of clone types in patients with IgAN was skewed; the majority of clones were unique, and only 12 BCR and 228 TCR CDR3 clones were public ones, of which 16 were expressed at a significantly higher frequency in patients with IgAN (P<0.001).
|
29568935 |
2018 |
|
Night sweats
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A 73-year-old man presenting with fatigue and drenching night sweats lasting for 2 weeks was diagnosed with chronic myeloid leukemia based on an analysis of a bone marrow biopsy and detection of the BCR-ABL1 fusion gene in peripheral blood.
|
30419862 |
2018 |
|
Pleural effusion disorder
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We identified 196 cases of PE in a series of 853 CML-CP DAS-treated patients (incidence 23.0%).
|
28971265 |
2018 |