|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
An 11-year-old male patient with the deletion of <i>IKZF1</i> (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(<i>BCR-ABL1</i>) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate.
|
31607921 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
<i>IKZF1</i> gene defects are associated with inferior treatment outcome in both childhood and adult B-cell precursor acute lymphoblastic leukemia and occur in more than 70% of <i>BCR-ABL1</i>-positive and <i>BCR-ABL1</i>-like cases of acute lymphoblastic leukemia.
|
29519871 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Loss-of-function but not dominant-negative intragenic <i>IKZF1</i> deletions are associated with an adverse prognosis in adult <i>BCR-ABL</i>-negative acute lymphoblastic leukemia.
|
28751559 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The genomic profile of ETV6-ABL1 acute lymphoblastic leukemia resembled that of BCR-ABL1 and BCR-ABL1-like cases with 80% of patients having concurrent CDKN2A/B and IKZF1 deletions.
|
27229714 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Alternative chimeric proteins, BCR-ABLp190 and BCR-ABLp210, are produced that are characteristic of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (Ph1-ALL) respectively.
|
11697484 |
2001 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recurrent genetic abnormalities in B-lymphoblastic leukemia with prognostic significance are well known and specifically delineated in the WHO 2008 classification (eg hyperdiploidy, t(9;22)(q34;q11.2); BCR-ABL1, t(12;21)(p13;q22); ETV6-RUNX1).
|
21822204 |
2011 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia.
|
23804397 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study.
|
19587702 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Primary established genetic abnormalities in B-cell precursor acute lymphoblastic leukemia include high hyperdiploidy (51-65 chromosomes), the translocations t(12;21)(p13;q22)/ETV6-RUNX1 fusion and t(9;22)(q34;q11)/BCR-ABL1 fusion, MLL rearrangements and intrachromosomal amplification of chromosome 21.
|
24816234 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The ABL-BCR fusion protein is a constitutively activated tyrosine kinase thought to play a central role in chronic myeloid leukemia (CML) and Philadelphia (Ph) chromosome acute lymphoid leukemia (ALL).
|
18603297 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
BCR/ABL fluorescent in situ hybridization study of chronic myeloid leukemia (CML) and Philadelphia(+) (Ph(+)) acute lymphoid leukemia (ALL) indicated that approximately 9% of patients exhibited an atypical hybridization pattern consistent with a submicroscopic deletion of the 5' region of ABL and the 3' region of the BCR genes on the 9q(+) chromosome.
|
11369654 |
2001 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Complex chromosome 9, 20, and 22 rearrangements in acute lymphoblastic leukemia with duplication of BCR and ABL sequences.
|
10640143 |
2000 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The prognostic value of IKZF1 deletions was evaluated in 2 cohorts of BCR-ABL1-positive BCP-ALL patients, before tyrosine kinase inhibitors (pre-TKI) and after introduction of imatinib (in the European Study for Philadelphia-Acute Lymphoblastic Leukemia [EsPhALL]).
|
24366361 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
IKZF1 deletions were associated with B-cell precursor acute lymphoblastic leukemia (P=0.036), BCR-ABL1-positive acute lymphoblastic leukemia (P<0.001), and higher white blood cell counts (P=0.005).
|
25261097 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
There have been successful examples of targeted therapy improving the outcome of some childhood cancers, such as the addition of an ABL class tyrosine kinase inhibitor to conventional chemotherapy substantially improving the cure rate for patients with BCR-ABL1 positive acute lymphoblastic leukemia.
|
31563145 |
2020 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interphase FISH for BCR-ABL1 rearrangement on neutrophils: A decisive tool to discriminate a lymphoid blast crisis of chronic myeloid leukemia from a de novo BCR-ABL1 positive acute lymphoblastic leukemia.
|
28444777 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells.
|
16205638 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four patients presented with B-lymphoblastic leukemia (B-ALL), and of them, two patients with t(8;9)(p22;p24.1) were proven to be B-lymphoblastic crisis of MPN; and the other two cases with t(9p24;v) both were de novo B-ALL, BCR-ABL1-like (Ph-like).
|
30401948 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis.
|
31173268 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The breakpoint cluster region-ABL proto-oncogene 1 (<i>BCR-ABL</i>) rearrangement leads to a p210 chimeric protein in typical chronic myeloid leukemia (CML), whereas 17-25% of patients with acute lymphocytic leukemia and 0.9-3% patients with <i>de novo</i> acute myeloid leukemia (AML) carry a p190<sup>BCR-ABL</sup> fusion protein.
|
29151902 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to characterize the rearrangements on 9p involving PAX5 and their clinical significance in adults with BCR-ABL1-positive acute lymphoblastic leukemia.
|
20534699 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These include new subtypes of acute myeloid leukemia defined by mutations in <i>RUNX1</i> or <i>BCR-ABL1</i> translocations as well as a constellation of somatic structural DNA alterations in acute lymphoblastic leukemia.
|
28600336 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We have mapped breakpoints within the 8.3-kb BamHI breakpoint cluster region in 31 patients with acute lymphoblastic leukemia and acute myeloid leukemia (AML) de novo and in 8 t-AML patients.
|
8634439 |
1996 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Frequency of BCR-ABL fusion oncogene in Pakistani childhood acute lymphoid leukemia (ALL) patients reflects ethnic differences in molecular genetics of ALL.
|
17762503 |
2007 |