Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Myeloid Leukemia, Chronic
|
0.700 |
FusionGene
|
disease |
ORPHANET |
|
|
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The total uptake of 3H-C 20:4 by platelets from CML patients did not differ from controls, but the release of radioactivity in response to thrombin was significantly lower (p < 0.01) in CML patients (32.3% +/- 4.9% of total radioactivity was released from control platelets; 19.0% +/- 7.4% from CML platelets).
|
6932231 |
1980 |
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
We report here observations on the occurrence of intermediate pre-B/B-cell phenotypes, immunoglobulin isotype switching and the asynchrony of immunoglobulin heavy and light chain expression in 30 cases of ALL and 3 cases of chronic myelogenous leukaemia in lymphoblastic crisis (CML-BC).
|
6782491 |
1981 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, we identified a region on chromosome 22, the breakpoint cluster region (bcr), which contains the chromosomal breakpoint in all patients with chronic myelocytic leukemia who are positive for Ph1.
|
3864009 |
1985 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analysis detected a bcr gene rearrangement within leukemic cells of a Philadelphia chromosome-negative chronic myelocytic leukemia (CML) patient that led to transcription of a novel 7.3 kb bcr RNA species.
|
2415665 |
1985 |
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia.
|
2989692 |
1985 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Using molecular approaches we demonstrate (i) a rearrangement within the CML breakpoint cluster region (bcr) on chromosome 22, and (ii) a joint translocation of bcr and c-abl oncogene sequences to the derivative chromosome 12.
|
3859408 |
1985 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have used probes for the bcr gene to obtain molecular evidence for the clonal origin of blast crisis in 2 patient with CML.
|
3085701 |
1986 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude that genomic changes in the bcr gene characteristic of CML can be present in the absence of a Ph1 chromosome.
|
2875753 |
1986 |
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Three cases of acute lymphocytic leukemia (ALL) and one case of chronic myelocytic leukemia in blastic crisis (CML-BC), which expressed only Tp40 antigen of cluster of differentiation (CD) 7 without erythrocyte rosette receptor (E), did not show rearrangements of TCR beta chain genes.
|
3098715 |
1986 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Chronic myelogenous leukemia (CML) is a human disease associated with a consistent chromosomal translocation that results in sequences from the c-abl locus on chromosome 9 being fused to sequences in a breakpoint cluster region (bcr) on chromosome 22.
|
3460176 |
1986 |
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Rearrangement in the breakpoint cluster region and the clinical course in Philadelphia-negative chronic myelogenous leukemia.
|
3094418 |
1986 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In chronic myelogenous leukemias (CML) with the t(9;22)(q34;q11) chromosome translocation the breakpoints on chromosome 22 occur within a 5.8-kilobase segment of DNA referred to as "breakpoint cluster region" (bcr).
|
3513189 |
1986 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In CML the abl gene is translocated from chromosome 9 to the centre of the bcr gene on chromosome 22 and this results in production of chimaeric bcr-abl RNA translated into a protein of relative molecular mass (Mr) 210,000 (210K).
|
2825022 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
At a molecular level the first two patients showed the same juxtaposition of c-abl and bcr genes as is seen in Ph-positive CML.
|
3476149 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Similarly, in mouse-human hybrids retaining a Ph1 chromosome derived from an acute lymphoblastic leukemia-in the absence of the 9q+ and 22, only BCR2 and BCR4 loci are retained, indicating that the breakpoint in this acute lymphoblastic leukemia, as in chronic myelogenous leukemia, is proximal to the BCR1 3' region, but distal to the IGLC locus and the BCR2 and BCR4 3' loci.
|
3118359 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Breakpoint cluster region rearrangements in chronic myelogenous leukemia with a masked Philadelphia chromosome.
|
3026611 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aberrant abl protein product of a chronic myelogenous leukemia (CML) blast crisis cell line (K562) and of five Philadelphia chromosome-positive CML patients in blast crisis were analyzed by an immune complex kinase assay using two antipeptide sera generated against the hydrophilic domain of v-abl and a region within the third exon of the breakpoint cluster region (bcr) respectively.
|
2885048 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The hallmark of human chronic myeloid leukaemia is a 9;22 chromosome translocation that fuses most of the c-abl oncogene to the 5' portion of the breakpoint cluster region (bcr) gene, such that a hybrid bcr-abl mRNA and polypeptide are generated.
|
3107980 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The chromosome 22 breakpoint in CML has been localized within a restricted 5.8 kb segment of DNA known as the breakpoint cluster region (bcr).
|
3478080 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of the breakpoint cluster region (bcr) in chromosome 22 revealed a rearrangement and thus confirmed the CML origin of the early T cell blasts.
|
3103711 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Two DNA probes for the breakpoint cluster region (bcr) of chromosome # 22 have been used to determine the proportion of Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML) cases that can be diagnosed by Southern blot analysis.
|
2822224 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A probe derived from the 3' end of the CML breakpoint cluster region (bcr) was localized in chronic myelocytic leukemia (CML) cases with complex Philadelphia translocations, [t(8;9;22)(q13;q34;q11) and t(12;9;22)(p11;q34;q11)], and with "masked" Ph chromosomes, [t(9;5;22)(q34;q31;q11) and t(9;22)(q22;q34)], by a chromosomal in situ hybridization technique.
|
3030534 |
1987 |
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In patients with CML the c-abl and bcr genes are translocated and abnormally expressed.
|
3479997 |
1987 |