|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The presence of a zone 4 rearrangement in the bcr of two chronic myelogenous leukemia (CML) cell lines and 25 CML patients was investigated by hybridization of HindIII-EcoRI double-digested DNA with the homologous HindIII-BglII breakpoint cluster region (bcr) probe.
|
3203293 |
1988 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our observations suggest a heterogeneity in Ph-negative CML with at least two subtypes: one with a rearranged bcr gene showing clinical and hematologic features akin to those of CML with a Ph translocation, and the other without such a rearrangement and with a somewhat different clinical feature.
|
2838155 |
1988 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Breakpoints on chromosome 22 in CML occur in a small region designated as the breakpoint cluster region (bcr).
|
2835901 |
1988 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Analysis of breakpoints within the bcr gene and their correlation with the clinical course of Philadelphia-positive chronic myelogenous leukemia.
|
3165294 |
1988 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
This upstream BCR breakpoint leads to inclusion of fewer BCR sequences in the fusion gene, compared with the BCR-ABL fusion gene of chronic myelogenous leukemia.
|
2833755 |
1988 |
|
Myeloid Leukemia, Chronic
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The latter as well as 902 or 927 amino acids are included within the CML-specific bcr-abl mRNA transcribed from the chimeric bcr-abl gene on chromosome 22.
|
3285291 |
1988 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The importance of the chimeric abl/bcr gene fusion product in the pathogenesis of CML is suggested as a characteristic feature, even in some patients with a so-called Philadelphia (Ph) negative CML.
|
3180010 |
1988 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analysis of CML ALAK failed to demonstrate a bcr gene rearrangement in seven patients known to have a bcr gene rearrangement in myeloid cells.
|
2473805 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Southern blot analysis showed breakpoint cluster region (bcr) rearrangement as observed in chronic myelogenous leukemia (CML).
|
2918760 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The standard t(9;22)(q34;q11) found in Philadelphia (Ph) chromosome positive chronic myeloid leukemia (CML) involves a highly restricted (5.8 kb) chromosome 22 breakpoint cluster region (bcr), which results in the formation of a chimeric gene comprising exons from the 5' end of bcr and protooncogene c-abl coding sequences from chromosome 9.
|
2649233 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Clinical stage of chronic granulocytic leukaemia and BCR breakpoint location in South-East Asian patients.
|
2736243 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the first the breakpoint is localized within the breakpoint cluster region of the BCR gene, analogous to the chromosome 22 breakpoint in chronic myeloid leukaemia.
|
2911461 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
About 50% of the Philadelphia-positive acute leukemias undergo molecular rearrangements outside the now classical bcr sequence (or M-BCR-1) rearranged in chronic myeloid leukemia (CML).
|
2930840 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
On DNA studies, the breakpoint cluster region (BCR) gene was not rearranged suggesting that the Ph1 involvement was not identical to that seen in chronic myelogenous leukemia (CML).
|
2523333 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, molecular analysis of the breakpoint cluster region (bcr) on chromosome 22 showed a rearrangement, confirming the CML origin of the blast cells.
|
2543592 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This article describes the use of biotin-labeled gene probes to detect the gene rearrangement of the breakpoint cluster region of chromosome 22 in chronic myelogenous leukemia.
|
2929502 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Within the group of Ph'-positive ALL patients having a bcr gene breakpoint, a correlation appears to exist between the age of the patient and the location of the breakpoint within the gene: all or the vast majority of pediatric patients analyzed to date do not have a Mbcr breakpoint as found in CML and in adult ALL.
|
2930839 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analysis revealed a rearrangement within the breakpoint cluster region on chromosome 22 similar to findings in chronic myeloid leukemia.
|
2731151 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The Philadelphia (Ph') chromosome in chronic myelogenous leukemia (CML) results in fusion of the bcr gene and c-abl oncogene, which transcribes into two types of chimeric bcr/abl mRNAs: the L-6 junction and the K-28 junction.
|
2730954 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
These data support the notion that the unusual genetic recombinations that give rise to BCR/ABL fusion genes in CML involve specific DNA sequences of BCR (and possibly ABL) and additional, recombinogenic sequences, at least some of which are present in loci known to be nonrandomly involved in complex Ph1 translocations.
|
2487142 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The Philadelphia chromosome of chronic myelogenous leukemia (CML) patients is caused by a translocation of the c-abl gene from chromosome 9 to the breakpoint cluster region (bcr) on chromosome 22.
|
2496773 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The interest of the study was strengthened by the fact that i(17q) is frequently seen in CML and by recent reports showing that genomic changes of c-abl and bcr genes can be present even in the absence of a Ph chromosome.
|
2598164 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Parallel Southern blot analyses on DNA from leukemic cells of five patients including two with simple translocations and three with complex ones revealed rearrangements of bcr with breakpoints occurring mostly in a 5' portion of 5.8-kb BamHI/BglII sequences, which are quite similar to those detected so far in CML cases with the standard Ph translocation.
|
2713815 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Molecular studies have demonstrated that the Philadelphia chromosome (Ph) translocation characteristic of chronic granulocytic leukemia (CGL) and 50% of the cases of Ph positive acute lymphocytic leukemia (ALL) involves a limited 5.8 Kb region on chromosome 22 termed the breakpoint cluster region (bcr).
|
2570895 |
1989 |
|
Myeloid Leukemia, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In chronic myeloid leukemia (CML) the breakage within the phl gene is largely confined to a 5.8-kb segment referred to as the breakpoint cluster region (bcr).
|
2683759 |
1989 |