S100B, S100 calcium binding protein B, 6285

N. diseases: 599; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 GeneticVariation disease BEFREE Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001). 21714070 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 GeneticVariation disease BEFREE Recently, associations were found between variations in the S100B gene and schizophrenia as well as bipolar affective disorder. 21112154 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE Significant differences in the subgroup depression (first-episode and recurrent depression) were also shown in 3 genotypes of S100B rs9722 and rs11911834 in patients and control subjects (P < 0.05). 19497163 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE Significant differences in the subgroup depression (first-episode and recurrent depression) were also shown in 3 genotypes of S100B rs9722 and rs11911834 in patients and control subjects (P < 0.05). 19497163 2009
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.400 GeneticVariation disease BEFREE This study was devised to evaluate and compare the methods for detecting trisomy 21 by polymerase chain reaction (PCR)-associated analysis of small tandem repeats (STR) of D21S11 and semiquantitative analysis of S100B of chromosome 21. 9933820 1999
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Animal studies have strongly implicated a role of S100B in spatial ability and our recent study of humans found that S100B gene polymorphisms (rs9722, rs1051169, and rs2839357) were associated with schizophrenia patients' spatial ability (as assessed by a block design task and a mental rotation task). 22019077 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Since variants within S100B have also been associated with schizophrenia susceptibility, we reanalyzed the data in trios with a history of psychosis, a phenotype in common between the two disorders. 17525977 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Recently, associations were found between variations in the S100B gene and schizophrenia as well as bipolar affective disorder. 21112154 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Moreover, GSK3B, HTR2A, PLA2G4A, and S100B variants may determine an anticipation of SCZ age of onset. 29164477 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE These results implicate a role for S100B gene polymorphisms in the cognitive functions of schizophrenia patients and encourage further investigation into spatial disability as an endophenotype of schizophrenia. 21070816 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.340 GeneticVariation disease BEFREE Association study of astrocyte-derived protein S100B gene polymorphisms with major depressive disorder in Chinese people. 19497163 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.340 GeneticVariation disease BEFREE No association of the rs9722 C >T in the S100B gene and susceptibility to major depression in a Chinese population. 18939940 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE S100B rs9722 C > T polymorphism appears not to be an important factor in susceptibility to MDD in a Chinese population. 18939940 2008
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Our findings did not suggest association of S100B gene polymorphisms in patients with MDD in China. 19497163 2009
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders 		0.330 GeneticVariation group BEFREE Since variants within S100B have also been associated with schizophrenia susceptibility, we reanalyzed the data in trios with a history of psychosis, a phenotype in common between the two disorders. 17525977 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.330 GeneticVariation group LHGDN Candidate gene analysis of 21q22: support for S100B as a susceptibility gene for bipolar affective disorder with psychosis. 17525977 2007
CUI: C0221480
Disease: Recurrent depression
Recurrent depression 		0.310 GeneticVariation disease BEFREE Significant differences in the subgroup depression (first-episode and recurrent depression) were also shown in 3 genotypes of S100B rs9722 and rs11911834 in patients and control subjects (P < 0.05). 19497163 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 GeneticVariation disease BEFREE S100A7, a member of S100 calcium binding protein family, is highly associated with breast cancer. 23000163 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 GeneticVariation disease BEFREE HER2 stimulates breast tumorigenesis via a number of intracellular signaling molecules, including PI3K/AKT and MAPK/ERK.S100A14,one member of the S100 protein family, is significantly associated with outcome of breast cancer patients. 24285542 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE S100A6 and S100A4, two of S100 protein family, have been suggested to be associated with cancer tumorigenesis and metastasis. 12239456 2002
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE Release of endogenous damage associated molecular patterns (DAMPs), including members of the S100 family, are associated with infection, cellular stress, tissue damage and cancer. 25706559 2015
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.100 GeneticVariation group BEFREE Deletion of the nef gene results in viral attenuation and confers protection against challenge with wild-type simian immunodeficiency virus in macaques. 10388660 1999
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.100 GeneticVariation group BEFREE When simian immunodeficiency virus (SIV) deleted in the nef gene caused no disease in macaques and provided protection against wild-type SIV challenge, hopes were high that the removal of nef would convert a pathogenic immunodeficiency virus into a live attenuated vaccine. 15090885 2004
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.100 GeneticVariation group BEFREE To understand the virologic basis of these differences, the nef gene from HIV-2-seropositive persons was analyzed because of its importance for disease progression in the genetically related simian immunodeficiency virus (SIV[MAC]). 9419171 1998
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.100 GeneticVariation group BEFREE A chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu, env, and nef genes of human immunodeficiency virus type 1 was generated. 7811533 1994