|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Shave biopsy and immunohistochemical studies revealed that the tumor was composed of malignant melanoma (MM) (highlighted by S100 and MART-1) intermixed with squamous cell carcinoma (SCC) (highlighted by cytokeratin and p63), and a diagnosis of combined MM-SCC was rendered.
|
31361351 |
2020 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although most of the tumor cells in both malignant melanoma and pleomorphic adenoma were labeled with the anti-sense RNA probe, unlabeled tumor cells were also present in their vicinity, suggesting there was a heterogeneity among the cells in both tumor types with respect to S100 protein mRNA expression.
|
1659204 |
1991 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although immunohistochemical (IHC) stains such as HMB45, Melan A, and S-100 are often utilized; the role of Sry-related HMG-box gene 10 (SOX10) in the diagnosis of melanoma in effusions has not been previously reported.
|
30794352 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined the potential value of this ratio for the follow-up, therapy monitoring and prognosis in melanoma compared with a reference marker (S100B, a melanoma-associated antigen).
|
14646622 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the use of S100B as a biomarker in melanoma is well established, to our knowledge its association with vitiligo activity has not yet been investigated.
|
28212812 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, melan-A, acid phosphatase 5, dopachrome tautomerase, S100-beta and acid ceramidase were found to be among the most important genes for melanoma.
|
12675527 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Common markers used to identify melanoma cell lines include: S100; HMB-45; and Melan-A.
|
27087056 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RT-PCR for tyrosinase mRNA and S-100 are significant prognostic factors for progression-free survival and OS in melanoma.
|
18845991 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunostaining revealed that major melanoma-associated antigens, such as S100 protein, HMB-45, melanotransferrin, chondroitin sulphate proteoglycan, and the gangliosides GD2 and GD3, were consistently expressed by the tumour tissue, severe combined immunodeficiency (SCID) mouse xenograft and derived cell lines.
|
8664053 |
1996 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Improved detection of aneuploidy in malignant melanoma using multiparameter flow cytometry for S100 protein and DNA content.
|
2768839 |
1989 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied cytokine profile of cellular Th1 (IL-2, IL-12, IFN-γ) and humoral Th2 (IL-4, IL-10) immune response, vascular endothelial growth factor (VEGFA), transforming growth factor-β 2 (TGF-β 2), S100 protein (S100A1B and S100BB), adhesion molecule CD44 and serum cytokines β2-microglobulin to analyze different peripheral blood mononuclear cell subpopuations of patients treated with dendritic vaccines and/or cyclophosphamide in melanoma patients in the course of adjuvant treatment.
|
29849947 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
On histopathological and immunohistochemical analysis with S-100 and homatropine methylbromide 45 the diagnosis of MM was confirmed.
|
31154344 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
We compared 3 tumor markers, TA90-immune complex (TA90IC), melanoma-inhibiting activity (MIA) protein, and S100B protein in Stage III melanoma patients undergoing adjuvant vaccine immunotherapy.
|
17661202 |
2007 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunocytochemical studies using the polyclonal anti-S-100 antibody and detection of alpha-mannosidase activity in culture medium proved the melanoma origin of B-HM8 cells.
|
8996567 |
1996 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The interaction between human S100 calcium-binding protein B (S100B) and the tumor suppressor protein p53 is considered to be a possible therapeutic target for malignant melanoma.
|
23375094 |
2013 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis.
|
24427375 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
S100B belongs to the S100 family and serum S100B (also known as S100beta) serves as a marker for metastasis in lung cancer, ovarian cancer and melanoma.
|
29345293 |
2018 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A dural biopsy was done which showed sheets of poorly differentiated tumor cells which expressed S100 and Melan A and were immunoreactive with Human Melanoma Black (HMB)-45 antibody, consistent with the diagnosis of malignant melanoma.
|
29876986 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In all cases, immunohistochemistry of the cartilaginous component was positive for S-100, which is not an indicator of melanoma because cartilage expresses S-100.
|
31260118 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It can be measured in cerebrospinal fluid and in blood, and increased S100B level in blood can be seen after, e.g., traumatic brain injury, certain neurodegenerative disorders, and malignant melanoma.
|
30710304 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The tumour cells were positive for melanocytic markers, including S100 and Human Melanoma Black 45, which led to an initial diagnosis of malignant melanoma.
|
29072181 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
S-100B protein and melanoma inhibitory activity protein in uveal melanoma screening. A comparison with liver function tests.
|
17264538 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.
|
17584159 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the 'MELmiR-7' panel characterised overall survival of melanoma patients better than both serum LDH and S100B (delta log likelihood = 11, p < 0.001).
|
26288839 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulating evidence over the past few decades has highlighted the potential use of circulating molecular biomarkers for melanoma diagnosis and prognosis, including lactate dehydrogenase (LDH), S100 calcium-binding protein B (S100B) and circulating tumor DNA (ctDNA) fragments.
|
29701682 |
2018 |