Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Segregation ratio distortion (SRD) with preferential transmission of expanded CAG alleles has been reported in Machado-Joseph disease (MJD/SCA3), spinocerebellar ataxia type I (SCA1), and dentatorubral-pallidoluysian atrophy (DRPLA).
|
10204858 |
1999 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that SCA may be occasionally caused by the SCA1 mutation and rarely caused by the DRPLA mutation and that, to date, the MJD mutation seems to be the most common cause of dominantly inherited SCA.
|
8559378 |
1996 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nine responsible genes have been identified for SCA-1, -2, -3, -6, -7, -8, -10, and -12 and dentatorubral-pallidoluysian atrophy (DRPLA).
|
11445634 |
2001 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Machado-Joseph disease-SCA3 was the most common type of autosomal dominant SCA in the Taiwanese cohort, accounting for 35 cases (47.3%), followed by SCA6 (8 [10.8%]), SCA2 (8 [10.8%]), SCA1 (4 [5.4%]), SCA7 (2 [2.7%]), dentatorubropallidoluysian atrophy (1 [1.4%]), and SCA8 (0%).
|
11448300 |
2001 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study we excluded SCA31 mutation from 119 unrelated patients with molecularly unassigned hereditary cerebellar ataxia, out of 512 pedigrees, after mutations in SCA1, 2, 3, 6, 7, 8, 10, 12, 17, and dentatorubral-pallidoluysian atrophy (DRPLA) had been excluded.
|
21163552 |
2012 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the dominant families, SCA1 accounted for 3%, SCA2 for 4%, SCA3/MJD for 24%, SCA6 for 31% and DRPLA for 12%.
|
12542511 |
2003 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutation analyses for SCA1, 2, 3, 6, 7, 8, 10, 12, 17, and DRPLA and frataxin genes were performed for 251 unrelated Finnish patients who presented with progressive ataxia disorder.
|
15691283 |
2005 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetically confirmed ADCA patients included those with Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3; 63.3%), SCA6 (20.0%), ADCA linked to chromosome 16q22.1 (10.0%), dentatorubral pallidoluysian atrophy (4.4%), SCA1 (1.1%) and SCA2 (1.1%).
|
19169038 |
2009 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
To date, eight different loci causing SCA have been identified: SCA1, SCA2, Machado-Joseph disease (MJD)/SCA3, SCA4, SCA5, SCA6, SCA7, and dentatorubropallidoluysian atrophy (DRPLA).
|
9613852 |
1998 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
At present, eight different genes causing ADCAs have been found: spinocerebeller ataxia type 1 (SCA1), SCA2, SCA3/Machado-Joseph disease (MJD), SCA6, SCA7, SCA8, SCA12 and dentatorubropallidoluysian atrophy (DRPLA).
|
11018707 |
2000 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the frequency of SCA1 (spinocerebellar ataxia type 1), SCA2, SCA3/MJD (spinocerebellar ataxia type 3/Machado-Joseph disease), SCA6, SCA7, and DRPLA (dentatorubropallidoluysian atrophy) CAG trinucleotide repeat expansions [(CAG)n] among persons diagnosed with hereditary SCA from Chinese families.
|
10768629 |
2000 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency of each disorder in a total of 155 unrelated families was 23.9% for Machado-Joseph disease (MJD), 29.0% for SCA6, 9.7% for SCA1, 7.7% for SCA2, and 2.6% for dentatorubral-pallidoluysian atrophy.
|
10785256 |
2000 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The recent demonstration that spinocerebellar ataxia type 2 (SCA2) is caused by a CAG repeat expansion within the ataxin-2 gene has allowed us to determine the frequency of SCA2 compared with SCA1, SCA3/Machado-Joseph disease (MJD), and dentatorubropallidoluysian atrophy (DRPLA) in patients with sporadic and inherited ataxia.
|
9106530 |
1997 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The most effective antisense oligonucleotide, (CUG)(7), also reduced mutant ataxin-1 and ataxin-3 mRNA levels in spinocerebellar ataxia 1 and 3, respectively, and atrophin-1 in dentatorubral-pallidoluysian atrophy patient derived fibroblasts.
|
21909428 |
2011 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most common cause of inherited SCA was a mutation at the SCA6 locus (25%), followed by mutation at the SCA1 locus (15%), SCA3 locus (5%) and dentatorubral-pallidoluysian atrophy locus (5%).
|
11359084 |
2001 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Possibilities of hereditary ataxias, including SCA1 (ataxin 1, ATXN1), SCA2 (ATXN2), Machado-Joseph disease/SCA3 (ATXN1), SCA6 (ATXN1), SCA7 (ATXN7), SCA12 (protein phosphatase 2, regulatory subunit B, beta isoform; PP2R2B), SCA17 (TATA box binding protein, TBP) and DRPLA (atrophin 1; ATN1), were excluded, and no mutations in the alpha-synuclein gene were found.
|
17420317 |
2007 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
In SBMA, the sperm of most patients and the skeletal muscle of all patients showed the same repeat number as their leukocytes, whereas the increase in the repeat number from leukocytes to sperm was evident in SCA1 and DRPLA patients.
|
8946111 |
1996 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency of SCA subtypes in autosomal dominant group was: 1) 5.5% for SCA1; 2) 2.4% for SCA2; 3) 27.6% for MJD/SCA3; 4) 25.5% for SCA6; 5) 0.3% for SCA17; and 6) 7.3% for DRPLA.
|
12116198 |
2002 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MJD/SCA3 was the most frequent ADCA (26 families, 57.8% of all families), followed by DRPLA (5 families, 11.2%), SCA7 (2 families, 4.4%), SCA2 and SCA1 (1 family each, 2.2% each); 10 families (22.2%) had no molecular diagnosis.
|
19659750 |
2010 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Venezuela, genetic epidemiological features of SCAs have been assessed during the last 30 years; mutations in ATXN1 (SCA1), ATXN2 (SCA2), ATXN3 (SCA3), CACNA1A (SCA6), ATXN7 (SCA7), ATXN8 (SCA8), ATXN10 (SCA10), TBP (SCA17) and ATN1 (dentatorubral pallidoluysian atrophy, DRPLA) loci were searched among 115 independent families.
|
26538302 |
2016 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Ataxia Molecular Diagnostics Testing Group was established to generate quantitative proficiency and outcomes data regarding molecular testing for the autosomal dominant cerebellar ataxias (spinocerebellar ataxia types 1 [SCA-1] through -3, -6, and -7, and dentatorubral-pallidoluysian atrophy) in North America.
|
11066010 |
2000 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular tests were performed including genetic analysis for SCA1, 2, and 3 (spinocerebellar ataxias), Huntington's disease (HD) and DRPLA, due to a possible overlapping in clinical presentation.
|
9858102 |
1998 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
To date, seven different genes causing autosomal dominant SCA have been mapped: SCA1, SCA2, Machado-Joseph disease (MJD)SCA3, SCA4, SCA5, SCA7 and dentatorubropallidoluysian atrophy (DRPLA).
|
9109985 |
1996 |
Dentatorubral-Pallidoluysian Atrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There are currently some types of autosomal dominant cerebellar ataxias such as Machado-Joseph disease (MJD), spinocerebellar ataxia types 1-5 (SCA1-5), or hereditary dentatorubropallidoluysian atrophy.
|
8815156 |
1996 |