Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings strongly argue in favor of the presence of pathophysiological changes in the eutopic endometrium of patients with endometriosis and make plausible MCP-1 as a key effector cell mediator involved in the pathogenesis of the disease.
|
9422530 |
1998 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, we conclude that factors besides the intraperitoneal adhesions contribute to the elevated peritoneal fluid MCP-1 levels in patients with endometriosis.
|
9647546 |
1998 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Effect of hormonal agents on monocyte chemotactic protein-1 expression by endometrial epithelial cells of women with endometriosis.
|
11056242 |
2000 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ovarian hormones modulate monocyte chemotactic protein-1 expression in endometrial cells of women with endometriosis.
|
10871649 |
2000 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Estradiol amplifies interleukin-1-induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis.
|
10690908 |
2000 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that MCP-1 may be involved in the histogenesis and early development of peritoneal endometriosis.
|
11213838 |
2001 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
ELISA was used to measure MCP-1 in the culture supernatants exposed to oxidized LDL and peritoneal fluid from control and endometriosis patients.
|
12372466 |
2002 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Peritoneal macrophages of women with endometriosis demonstrated an increased capacity to secrete MCP-1 either spontaneously or after stimulation with lipopolysaccharide.
|
12009356 |
2002 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The serum of women with endometriosis induced higher secretion of MCP-1 by U937 cells than that of control women, particularly in the initial stages of endometriosis (stages I-II), and recombinant IL-1RII (rIL-1RII) significantly blocked that secretion.
|
12372465 |
2002 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among various chemokines, regulated-on-activation, normal-T-cell-expressed and -secreted (RANTES) and monocyte chemotactic protein 1 (MCP-1) concentrations have been shown to be increased in the peritoneal fluid of women with endometriosis.
|
14981141 |
2004 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesize that increased levels of CCL2 in the endometriotic environment may upregulate FASLG expression in human endometrial stromal cells and induce a local immunotolerance in endometriosis.
|
16687653 |
2006 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Three cytokines were significantly higher in the serum of subjects with endometriosis than in the control group: interleukin-6 (IL-6) [4.41 pg/ml (range: 1.47-15.01) versus 0.97 pg/ml (range: 0.29-2.98), respectively; p<0.001], monocyte chemotactic protein-1 (MCP-1) [37.91 pg/ml (range: 24.54-94.74) versus 22.13 pg/ml (range: 13.85-39.45), respectively; p<0.001], and interferon-gamma (INF-gamma) [19.01 pg/ml (range: 1.19-73.52) versus 0.30 pg/ml (range: 0.00-13.05), respectively; p<0.001].
|
17582674 |
2008 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
During menstrual phase, increased endometrial mRNA levels of alpha(V) integrin, combined alpha(V)beta(3) integrins, and increased peritoneal IL-1 beta mRNA levels--but decreased peritoneal MCP-1 mRNA levels--were observed in women with endometriosis compared with control subjects.
|
17678915 |
2008 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Panel of markers can accurately predict endometriosis in a subset of patients.
|
17706208 |
2008 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In contrast, the percentages of CD14+ cells producing TNF-alpha, IL-6, IL-10, MCP-1, and IL-8 were significantly higher in PB than PF of women with endometriosis.
|
17207568 |
2008 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This method showed a sensitivity of 92.2%, a specificity of 81.6%, a negative predictive value of 83.3%, a positive predictive value of 92.3%, a likelihood ratio of a positive test result of 5.017, and a likelihood ratio of a negative test result of 0.096 to predict the presence or absence of endometriosis.The results imply the potential use of CCR1 mRNA, MCP-1, and CA125 protein measurements for the diagnosis or exclusion of endometriosis.
|
19050323 |
2008 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Proliferative phase samples showed higher epithelial IL-8 and MCP-1 expressions in eutopic endometrium of women with endometriosis compared with that of normal women.
|
18314120 |
2009 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, we observed that the sex steroid treatment stimulated MCP-1 mRNA and protein expression in HEECs from women with endometriosis (P < .05).
|
19933497 |
2010 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study has demonstrated for the first time that the abnormal lower CD82 expression in ESCs induced by TCDD and estrogen may be an important molecular basis of endometriosis pathogenesis through enhancing the CCL2 secretion and CCR2 expression and the invasion of ESCs via MAPK and integrinβ1 signal pathway.
|
21685244 |
2011 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Statins inhibit monocyte chemotactic protein 1 expression in endometriosis.
|
22267540 |
2012 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nonetheless, interferon (IFN)-γ, Interleukin (IL)-10 and monocyte chemoattractant protein-1 (MCP-1) levels were higher in the supernatant of E-MenSCs-PBMC co-cultures.
|
24939730 |
2014 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the effect of pre-operative oral simvastatin administration on MCP-1 gene expression and serum MCP-1 protein levels in patients with endometriosis.
|
28950844 |
2017 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concentrations of SCGF-β, IL-8, HGF, and MCP-1 were significantly higher, while IL-13 was significantly lower in the endometriosis group compared with the group without endometriosis.
|
28433374 |
2017 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ESC from endometrial biopsies of six subjects with histologically confirmed endometriosis were treated for 6 h with medium alone or with TNF-α (10 or 100 ng/ml) in the presence of dienogest (DNG), medroxyprogesterone acetate (MPA) and norethisterone acetate (NETA) 10-5 M. The progestin-mediated change in IL6, IL8 and MCP-1 mRNA transcription was measured, as was the PRA, PRB, GR, AR and MCR protein expression.
|
28412861 |
2017 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of TFF3 in PF of women with endometriosis were significantly increased ( P < .05) and correlated with local levels of known biomarkers for endometriosis: cancer antigen (CA) 125, CA-19-9, interleukin 8, monocyte chemotactic protein 1, and matrix metalloproteinase 7.
|
27330011 |
2017 |