|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results support the premise that MCP-1 is secreted by VSMC in atherosclerotic plaques as well as by endothelial cells and macrophages and contributes to the pathogenesis of atherosclerosis.
|
8580375 |
1995 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We now report MCP-1 gene expression following de-endothelialization of iliac arteries in the pig, a species which can develop spontaneous atherosclerosis.
|
8872602 |
1996 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 (MCP-1) is a potent agonist for mononuclear leukocytes and has been implicated in the pathogenesis of atherosclerosis and granulomatous lung disease.
|
9366570 |
1997 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together with the results of earlier studies, these data provide compelling evidence that MCP-1 plays a critical role in the initiation of atherosclerosis.
|
10079097 |
1999 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We devised a new strategy for anti-MCP-1 gene therapy to treat atherosclerosis by transfecting an N-terminal deletion mutant of the human MCP-1 gene into a remote organ (skeletal muscle) in apolipoprotein E-knockout mice.
|
11319201 |
2001 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 (MCP-1) has been implicated as a powerful pro-inflammatory mediator and may represent a potentially important, therapeutic opportunity for treatment of inflammatory disease and atherosclerosis.
|
11591377 |
2001 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Studies in animals have shown that resistance to atherosclerosis in spite of hypercholesterolemia is affected by factors such as high-density lipoprotein (HDL) phospholipids that enhance reverse cholesterol transport, non-responsiveness to induction or lack of monocyte chemotactic protein-1 (MCP-1), C-C chemokine receptor 2 (CCR2), macrophage colony stimulating factor (MCSF), or vascular cell adhesion molecule-1 (VCAM-1).
|
11755917 |
2002 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, our investigations lend support to the importance of PDGF-A, PDGF-B, and MCP-1 in the pathogenesis of atherosclerosis, and the beneficial role of n-3 fatty acids therein.
|
11838000 |
2001 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
In conclusion, the secretion of high levels of MCP-1 resulting from interactions of P. gingivalis with endothelial cells could enhance atherosclerosis progression by contributing to the recruitment of monocytes.
|
12443832 |
2002 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the current study, the authors examined whether the organic germanium suppresses the MCP-1-induced monocyte migration in vitro and the development of atherosclerosis in WHHL rabbits in vivo.
|
12548076 |
2003 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Atheroprotective Mechanisms Activated by Fluid Shear Stress in Endothelial Cells.
|
12677255 |
2002 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects.
|
12928151 |
2003 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein 1 (MCP-1) and the receptor for MCP-1, CCR2, play a pivotal role in the recruitment of monocytes to the subendothelium, which is the initial event in atherosclerosis.
|
13678532 |
2003 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in atherosclerosis.
|
14620921 |
2003 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in hypercholesterolemic mice.
|
14739122 |
2004 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that histamine and IL-4, which are both synthesized in the arterial intima, chronically participates in the pathogenesis of atherosclerosis via the enhanced expression of monocytic MCP-1, CCR2 and endothelial adhesion molecules.
|
15189499 |
2004 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic HD patients.
|
15226634 |
2004 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
When adjusted for known cardiovascular risk factors, the MCP-1-2518G allele was associated with subclinical atherosclerosis (OR 5.72, 95% CI 1.74 to 18.80, P=0.004).
|
15466648 |
2004 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
When adjusted for known cardiovascular risk factors, the MCP-1-2518G allele was associated with subclinical atherosclerosis (OR 5.72, 95% CI 1.74 to 18.80, P=0.004).
|
15466648 |
2004 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Our data are consistent with the hypothesis that MCP-1 is involved in the pathogenesis of human atherosclerosis and myocardial infarction.
|
16116069 |
2005 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data are consistent with the hypothesis that MCP-1 is involved in the pathogenesis of human atherosclerosis and myocardial infarction.
|
16116069 |
2005 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Based on our findings, we suggest that Nrf2-dependent HO-1 expression induced by HA inhibits MCP-1 secretion, VCAM-1 expression and NF-kappaB activation associated with vascular injury and inflammation in atherosclerosis.
|
16246346 |
2006 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms MCP-1 -2518A>G and CCR2 190G>A have been reported to be associated with increased risk for developing atherosclerosis.
|
16356504 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Plasma MCP-1 concentration is genetically determined and associated with age and smoking habit and it also correlates with subclinical atherosclerosis in HIV-infected patients.
|
16445900 |
2006 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Plasma MCP-1 concentration is genetically determined and associated with age and smoking habit and it also correlates with subclinical atherosclerosis in HIV-infected patients.
|
16445900 |
2006 |