|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Tumor cell seeding to the lungs resulted in enhanced expression of a proteoglycan syndecan-4 by endothelial cells that correlated with accumulation of the dnCCL2-HSA chimera in the vicinity of tumor cells.
|
26806351 |
2016 |
|
Heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Syndecan-4, a transmembrane heparan sulfate proteoglycan, is essential for pathological remodeling, and we here investigated its expression and shedding during heart failure.
|
23374111 |
2013 |
|
Congestive heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Syndecan-4, a transmembrane heparan sulfate proteoglycan, is essential for pathological remodeling, and we here investigated its expression and shedding during heart failure.
|
23374111 |
2013 |
|
Mycobacterium Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Sdc4 mRNA expression was increased in human and mouse alveolar epithelial cells after mycobacterial infection.
|
27279134 |
2016 |
|
Ureteral obstruction
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Synd4 expression was significantly enhanced after unilateral ureteral obstruction compared with contralateral kidneys.
|
29101181 |
2018 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Syndecan-4 Inhibits the Development of Pulmonary Fibrosis by Attenuating TGF-β Signaling.
|
31600983 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
A biopsy acquired after disease progression revealed the original SDC4-ROS1 fusion along with a KRAS point mutation (p.G12D).We reviewed the related literature to determine the frequency of gene mutations in non-small cell lung cancer patients.
|
28971587 |
2018 |
|
Pneumonia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Addition of both suPAR and syndecan-4 to the Pneumonia Severity Index significantly improved their prognostic accuracy, with an AUC of 0.885.
|
29368632 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although both serum SDC-1 and SDC-4 showed a downward trend in COPD patients, only SDC-1 levels were correlated positively with the ratio of FEV1/FVC and parameters of small airway obstruction.
|
31695352 |
2019 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At the level of matrix effectors implicated in colon cancer progression we report that pmAb is a potent inhibitor of constitute and EGF-mediated gene expression of certain matrix effectors, such as membrane-type 1 metalloproteinase (MT1-MMP), extracellular metalloproteinases inducer (EMMPRIN), urokinase plasminogen activator (uPA) and syndecan-4.
|
22956286 |
2013 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At the level of matrix effectors implicated in colon cancer progression we report that pmAb is a potent inhibitor of constitute and EGF-mediated gene expression of certain matrix effectors, such as membrane-type 1 metalloproteinase (MT1-MMP), extracellular metalloproteinases inducer (EMMPRIN), urokinase plasminogen activator (uPA) and syndecan-4.
|
22956286 |
2013 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Autotaxin-β interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis.
|
30237860 |
2018 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Besides, si-β-catenin was observed to inhibit the promotion of PTC cell migration and invasion caused by SDC4 overexpression.
|
30165731 |
2018 |
|
Degenerative polyarthritis
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Both VEGF and syndecan-4 are expressed by chondrocytes and both are involved in the regulation of matrix metalloproteinase-3, resulting in the activation of aggrecanase II (ADAMTS-5), which is essential in the pathogenesis of OA.
|
25274915 |
2014 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Cell surface heparan sulfate proteoglycans (HSPGs) are principal mediators of cancer cell properties and the E2-ER pathway as well as those activated by EGFR and IGFR have significant roles in regulating the expression of certain cell surface HSPGs, such as syndecan-2 (SDC-2), syndecan-4 (SDC-4) and glypican-1.
|
23374155 |
2013 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Cell surface heparan sulfate proteoglycans (HSPGs) are principal mediators of cancer cell properties and the E2-ER pathway as well as those activated by EGFR and IGFR have significant roles in regulating the expression of certain cell surface HSPGs, such as syndecan-2 (SDC-2), syndecan-4 (SDC-4) and glypican-1.
|
23374155 |
2013 |
|
Heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Circulating shed syndecan-4 is increased in heart failure patients, however the pathophysiological and molecular consequences associated with syndecan-4 shedding remain poorly understood.
|
26449522 |
2015 |
|
Congestive heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Circulating shed syndecan-4 is increased in heart failure patients, however the pathophysiological and molecular consequences associated with syndecan-4 shedding remain poorly understood.
|
26449522 |
2015 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results demonstrated a new mechanism of SDC4 in initiating the inflammation and inhibiting the apoptosis of RA-FLSs and that a potential target for the diagnosis and treatment of RA in the clinic might be developed.
|
31309562 |
2020 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dextran sulfate sodium (DSS)-induced colitis was monitored in wild type and Sdc4-deficient (Sdc4-/-) mice by assessment of body weight, histology, inflammatory cellular infiltration, and colon length.
|
30053064 |
2018 |
|
Left ventricular dilatation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Echocardiographic, histochemical and cardiomyocyte size measurements showed that syndecan-4(-/-) mice did not develop concentric myocardial hypertrophy as found in wild-type mice, but rather left ventricular dilatation and dysfunction following pressure overload.
|
22164265 |
2011 |
|
Aortic Valve Stenosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Finally, patients with hypertrophic myocardium due to aortic stenosis had increased syndecan-4 levels with decreased pS179 which was associated with increased NFAT activation.
|
22164265 |
2011 |
|
Aortic Valve Stenosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
For a similar severity of AS, male patients demonstrated higher indexed left ventricular (LV) volumes and mass, more concentric remodeling (higher LV mass/volume), a trend to more late gadolinium enhancement (present in 51.1% men vs. 34.1% women; p = 0.057), and higher extracellular volume index than female patients (13.27 [interquartile range (IQR): 11.5 to 17.0] vs. 11.53 [IQR: 10.5 to 13.5] ml/m<sup>2</sup>, p = 0.017), with worse systolic and diastolic function and higher MMP-3 and syndecan-4 levels, whereas female patients had higher septal E/e'.
|
29248646 |
2019 |
|
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Four molecules (LA16c-380H5.2, RP11-203J24.8, MLF1 and SDC4) could potentially serve as diagnostic biomarkers of THCA with high sensitivity and specificity.
|
29340074 |
2017 |
|
Lower limb ischemia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, poor homing of synd4-/- EPCs was observed in a mouse model of lower limb ischemia.
|
27662820 |
2017 |