Non-Small Cell Lung Carcinoma
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
A biopsy acquired after disease progression revealed the original SDC4-ROS1 fusion along with a KRAS point mutation (p.G12D).We reviewed the related literature to determine the frequency of gene mutations in non-small cell lung cancer patients.
|
28971587 |
2018 |
Leg Ulcer
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
None of the examined SDC4 and NRP1 polymorphisms showed a difference in their allelic distribution between leg ulcer patients (n=92) and controls (n=92).
|
18638267 |
2008 |
Leg Ulcer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
None of the examined SDC4 and NRP1 polymorphisms showed a difference in their allelic distribution between leg ulcer patients (n=92) and controls (n=92).
|
18638267 |
2008 |
Non-Small Cell Lung Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Identifying and targeting ROS1 gene fusions in non-small cell lung cancer.
|
22919003 |
2012 |
Bacterial Infections
|
0.200 |
Biomarker
|
group |
RGD |
Role of Syndecan-4 in the cellular invasion of Orientia tsutsugamushi.
|
15001228 |
2004 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In Sdc4-/- mice, colitis-like symptoms including severe weight loss, shortened colon length, histological damage, and invasion of macrophages and granulocytes were markedly aggravated compared with wild type (WT) animals.
|
30053064 |
2018 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The fact that reducing SDC-4 expression by RNA interference decreased SDF-1-induced Huh7 hepatoma cell migration and invasion strongly indicates that SDC-4 may be an auxiliary receptor for SDF-1.
|
17259344 |
2007 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Syndecan-1 and syndecan-4 are involved in RANTES/CCL5-induced migration and invasion of human hepatoma cells.
|
19632304 |
2009 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Global important changes in cell adhesion receptors, which include integrins and syndecan-4 triggered by IGF-IR inhibition, regulate adhesion and invasion.
|
28079144 |
2017 |
Heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Syndecan-4, a transmembrane heparan sulfate proteoglycan, is essential for pathological remodeling, and we here investigated its expression and shedding during heart failure.
|
23374111 |
2013 |
Heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Circulating shed syndecan-4 is increased in heart failure patients, however the pathophysiological and molecular consequences associated with syndecan-4 shedding remain poorly understood.
|
26449522 |
2015 |
Heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data suggest that syndecan-4 is essential for the compensated hypertrophy and the maintenance of cardiac function during the process of heart failure following pressure overload.
|
28395201 |
2017 |
Congestive heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Circulating shed syndecan-4 is increased in heart failure patients, however the pathophysiological and molecular consequences associated with syndecan-4 shedding remain poorly understood.
|
26449522 |
2015 |
Congestive heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data suggest that syndecan-4 is essential for the compensated hypertrophy and the maintenance of cardiac function during the process of heart failure following pressure overload.
|
28395201 |
2017 |
Congestive heart failure
|
0.040 |
Biomarker
|
disease |
BEFREE |
Syndecan-4, a transmembrane heparan sulfate proteoglycan, is essential for pathological remodeling, and we here investigated its expression and shedding during heart failure.
|
23374111 |
2013 |
Degenerative polyarthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Using an immunoassay for the extracellular domain of syndecan-4, we found 68% of the syndecan-4 in the culture supernatant of OA chondrocytes culture, suggesting that a large majority of the syndecan-4 is shed and released in the extracellular medium.
|
31455087 |
2019 |
Degenerative polyarthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our data suggest that strategies aimed at the inhibition of syndecan-4 will be of great value for the treatment of cartilage damage in osteoarthritis.
|
19684582 |
2009 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
These findings indicate the genetic importance of DC heparan sulfate proteoglycans in tumor growth and may guide therapeutic development of novel strategies to target syndecan-4 and heparan sulfate in cancer.
|
27237321 |
2016 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
We demonstrated here, that among all cell surface heparan-sulfate proteoglycans, syndecan-4 (SDC4) was essential for cancer cell interaction with ATXβ but was restrained by heparan-sulfate chains.
|
30237860 |
2018 |
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
We demonstrated here, that among all cell surface heparan-sulfate proteoglycans, syndecan-4 (SDC4) was essential for cancer cell interaction with ATXβ but was restrained by heparan-sulfate chains.
|
30237860 |
2018 |
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
These findings indicate the genetic importance of DC heparan sulfate proteoglycans in tumor growth and may guide therapeutic development of novel strategies to target syndecan-4 and heparan sulfate in cancer.
|
27237321 |
2016 |
Aortic Valve Stenosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
For a similar severity of AS, male patients demonstrated higher indexed left ventricular (LV) volumes and mass, more concentric remodeling (higher LV mass/volume), a trend to more late gadolinium enhancement (present in 51.1% men vs. 34.1% women; p = 0.057), and higher extracellular volume index than female patients (13.27 [interquartile range (IQR): 11.5 to 17.0] vs. 11.53 [IQR: 10.5 to 13.5] ml/m<sup>2</sup>, p = 0.017), with worse systolic and diastolic function and higher MMP-3 and syndecan-4 levels, whereas female patients had higher septal E/e'.
|
29248646 |
2019 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
No association was found with SDC4 and breast cancer in our population.
|
25361632 |
2015 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sulfated Glycoaminoglycans and Proteoglycan Syndecan-4 Are Involved in Membrane Fixation of LL-37 and Its Pro-Migratory Effect in Breast Cancer Cells.
|
31547381 |
2019 |
Myocardial Infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
Gender differences in the association of syndecan-4 with myocardial infarction: The population-based Tromsø Study.
|
30278359 |
2018 |