Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS.
|
22081247 |
2012 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
T2D variants were associated with PCOS phenotype parameters including those in THADA and WFS1 with testosterone levels, ENPP/PC1 with triglyceride levels, FTO with glucose levels and KCNJ11 with FSH levels.
|
22389004 |
2013 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
|
22885925 |
2012 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variation in DENND1A was strongly associated with PCOS in the study cohort (p(combined cohorts)=10(-8)); multiple variants in THADA were also associated with PCOS, while there was no significant evidence for association of LHCGR variation with PCOS.
|
22180642 |
2012 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
THADA_rs13429458 Minor Allele Increases the Risk of Polycystic Ovary Syndrome in Asian, but Not in Caucasian Women: A Systematic Review and Meta-Analysis.
|
31487746 |
2019 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
|
21151128 |
2011 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
|
21151128 |
2011 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
|
22885925 |
2012 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In a previous genome-wide association study, the SNP variants rs13429458, rs12478601, rs2479106, rs10818854 and rs13405728 in the THADA, DENND1A and LHCGR genes were identified as being independently associated with PCOS.
|
23208300 |
2013 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our previous research had identified three susceptibility loci (rs2479106, DENND1A; rs13405728, LHCGR; rs13429458, THADA) for PCOS in Han Chinese women.
|
25978310 |
2015 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies based on adequate population samples have shown a higher frequency of genetic polymorphisms of the LHCGR, THADA and DENND1A genes in women with PCOS.
|
25835506 |
2015 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
It was suggested that the TT genotype of LHCGR rs13405728, CC genotype of THADA rs12478601 and AG + GG genotype of DENND1A rs2479106 had poor outcomes of IVF-ET in treating PCOS.
|
30844144 |
2019 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome.
|
26416764 |
2015 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the polycystic ovary syndrome (PCOS) related single nucleotide polymorphisms (SNPs) rs13405728 (in gene LHCGR), rs13429458 (in gene THADA) and rs2479106 (in gene DENND1A) in women with endometrial carcinoma.
|
22902918 |
2012 |
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
|
30566500 |
2018 |
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
We identify six signals for PCOS at genome-wide statistical significance (P<5 × 10(-8)), in/near genes ERBB4/HER4, YAP1, THADA, FSHB, RAD50 and KRR1.
|
26416764 |
2015 |
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
Variants in DENND1A (P = .0002), THADA (P = .035), FSHR (P = .007), and INSR (P = .046) were associated with PCOS in Europeans.
|
25303487 |
2015 |