Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, overexpression of CHP2 activated AKT signaling and suppressed the transactivation of the forkhead box O3 (FOXO3/FOXO3a) transcription factor.<b>Implications:</b> This study discovers a previously unrecognized role of CHP2 in the progression of breast cancer and supports the significance of this gene as a novel prognostic biomarker and a potential therapeutic target for breast cancer.<i></i>.
|
29967111 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
A CHP2-negative human epithelial ovarian cancer cell line OVCAR3 was used for this study.
|
17708351 |
2007 |
Chlamydia psittaci infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Molecular characterization of a bacteriophage (Chp2) from Chlamydia psittaci.
|
10729119 |
2000 |
Epithelial ovarian cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
A CHP2-negative human epithelial ovarian cancer cell line OVCAR3 was used for this study.
|
17708351 |
2007 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, overexpression of CHP2 activated AKT signaling and suppressed the transactivation of the forkhead box O3 (FOXO3/FOXO3a) transcription factor.<b>Implications:</b> This study discovers a previously unrecognized role of CHP2 in the progression of breast cancer and supports the significance of this gene as a novel prognostic biomarker and a potential therapeutic target for breast cancer.<i></i>.
|
29967111 |
2018 |
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
|
17708351 |
2007 |
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Four other Ags were identified to be expressed in particular types of cancer cell lines (HCA520 in an ovarian cancer cell line, HCA59 and HCA67 in a colon cancer cell line, HCA58 in colon and ovarian cancer cell lines), but not in the normal tissue counterpart(s).
|
12097419 |
2002 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
|
17708351 |
2007 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The performance characteristics of the CHP2 assay were determined by sequencing various cell line mixtures and 55 different FFPE tumors on the Ion Torrent PGM platform.
|
26376646 |
2015 |
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
|
17708351 |
2007 |
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
The current study provides the first evidence that overexpression of the CHP2 gene affects the biological behavior of ovarian cancer cell line OVCAR3 and is one of key mechanisms for ovarian carcinoma progression, suggesting that CHP2 may be an attractive target for biological anticancer therapy.
|
17708351 |
2007 |
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
|
17708351 |
2007 |
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Four other Ags were identified to be expressed in particular types of cancer cell lines (HCA520 in an ovarian cancer cell line, HCA59 and HCA67 in a colon cancer cell line, HCA58 in colon and ovarian cancer cell lines), but not in the normal tissue counterpart(s).
|
12097419 |
2002 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
CHP2-transfected OVCAR3/CHP2 cells showed increased proliferation rates and exhibited increased activities of cell adhesion, migration and invasion.
|
17708351 |
2007 |
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The biological function of CHP2 related to cancer progression is still unknown.
|
17708351 |
2007 |