|
Alexithymia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
From our analysis, variants in the genes ABCB4, TP53AIP1, ARHGAP32 and TMEM88B were identified linked to the alexithymia phenotype.
|
25882097 |
2015 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
The mechanism of TP53AIP1 inhibition of proliferation and growth of breast cancer cells includes cell cycle arrest, apoptosis promotion (<i>p</i> < 0.01), promotion of the expression of cleaved-caspase-3 (<i>p</i> < 0.01), cleaved-caspase-9 (<i>p</i> < 0.01), B cell lymphoma/leukemia-2 (Bcl-2)-associated X protein, and p53 (<i>p</i> < 0.01), and the inhibition of Bcl-2, Ki67, and PI3K/Akt pathways (<i>p</i> < 0.01).
|
31281721 |
2019 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transgenic technology was used to enhance the expression of TP53AIP1 in breast cancer cell lines, MDA-MB-415 and MDA-MB-468, and to observe the effects of gene overexpression on the proliferation, cell cycle, and apoptosis of breast cancer cells.
|
31281721 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
H. pylori infection induces gastric mucosal inflammation and DNA damage of epithelial cells, which associate with gastric carcinogenesis. p53AIP1 is expressed after DNA damage and induces apoptosis in human cell lines.
|
18277906 |
2008 |
|
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To investigate the role of these genes in non-small cell lung cancer, we compared the relationship between p53AIP1 or survivin gene expression and the clinicopathological status of lung cancer.
|
19228369 |
2009 |
|
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To investigate the role of this gene for non-small cell lung cancer, we compared the relationship between p53AIP1 gene expression and clinicopathological status of lung cancer.
|
17851056 |
2008 |
|
Chronic gastritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.
|
18277906 |
2008 |
|
Cutaneous Melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In all patients, TP53AIP1 truncating variants were strongly associated with CMM risk (two-sided Fisher exact test = 0.004, OR = 3.3[1.3-8.5]).
|
29359367 |
2018 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.
|
18277906 |
2008 |
|
Infection
|
0.020 |
AlteredExpression
|
group |
LHGDN |
Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.
|
18277906 |
2008 |
|
Infection
|
0.020 |
AlteredExpression
|
group |
LHGDN |
Insights in gastric carcinogenesis from Helicobacter pylori infection.
|
18277909 |
2008 |
|
Infection caused by Helicobacter pylori
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To examine the significance of alteration of p53-regulated apoptosis-induced protein 1 (p53AIP1) expression in gastric carcinogenesis in patients with Helicobacter pylori infection.
|
18277906 |
2008 |
|
Intestinal metaplasia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In patients with chronic gastritis, antral mucosa with high p53AIP1 expression tended to have severe intestinal metaplasia.No mutation was found at p53 codon-46.
|
18277906 |
2008 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We further demonstrate that HBx-deregulated increased p53AIP1 expression is relevant in HCC livers and define a functional role for p53AIP1 in mediating HBx-induced apoptosis in vitro.
|
23149944 |
2013 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line.
|
15004724 |
2004 |
|
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
p53AIP1 expression can be a prognostic marker in non-small cell lung cancer.
|
17851056 |
2008 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transgenic technology was used to enhance the expression of TP53AIP1 in breast cancer cell lines, MDA-MB-415 and MDA-MB-468, and to observe the effects of gene overexpression on the proliferation, cell cycle, and apoptosis of breast cancer cells.
|
31281721 |
2019 |
|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To investigate the role of this gene for non-small cell lung cancer, we compared the relationship between p53AIP1 gene expression and clinicopathological status of lung cancer.
|
17851056 |
2008 |
|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To investigate the role of these genes in non-small cell lung cancer, we compared the relationship between p53AIP1 or survivin gene expression and the clinicopathological status of lung cancer.
|
19228369 |
2009 |
|
Malignant neoplasm of prostate
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Constitutional mutations of TP53AIP1 had previously been involved in susceptibility to prostate cancer.
|
29359367 |
2018 |
|
Malignant neoplasm of prostate
|
0.030 |
Biomarker
|
disease |
BEFREE |
The large sample size of the combined cohort rejects a high-risk effect greater than 2.2 and indicates a limited role of TP53AIP1 in prostate cancer predisposition.
|
22457820 |
2012 |
|
Malignant neoplasm of prostate
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that loss-of-function variants in p53AIP1 associated with the risk of sporadic prostate cancer and further support the concept that the genetic defects in the DNA damage-response genes play an important role in the development of prostate cancer.
|
17079449 |
2006 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the antrum, p53AIP1 mRNA expression was significantly lower in patients with gastric cancer than in those with chronic gastritis (P<0.05).
|
18277906 |
2008 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In 20 of the 30 cell lines, p53AIP1-induced apoptosis was observed, and in 12 of these p53AIP1-sensitive cancer cell lines, the apoptotic effects of p53AIP1 were greater than those of p53 itself.
|
14720333 |
2004 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The present study determined that miR‑505‑5p functions as an oncogene, promoting lung cancer cell proliferation and inhibiting cancer cell apoptosis via the targeting of tumor protein P53‑regulated apoptosis‑inducing protein 1 (TP53AIP1).
|
30864684 |
2019 |