Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We show that NOD2/CARD15 mutations determine ileal disease only.
|
11910336 |
2002 |
Ileal Diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
IBD and genetics: new developments.
|
14743885 |
2003 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genotype phenotype analyses revealed that NOD2/CARD15 mutations determined younger age at disease diagnosis (P = 0.03), ileal disease location (P = 0.01) and ileocecal resections (P = 0.0002).
|
15142196 |
2004 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, ileal disease was also associated with the presence of at least one NOD2 susceptibility allele (p=0.001; OR=3.838) and, the risk of ileal CD was increased if TLR4 variants were presents (p<0.050; OR=4.160).
|
27290609 |
2016 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CARD15 mutations also influenced the age of onset of ileal disease (P < 0.02).
|
15973117 |
2005 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Ileal disease has been linked to a mutation in the NOD2 gene.
|
15618294 |
2005 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
NOD2/CARD15 variant frequency in ileal disease did not differ significantly among studies, whereas a comparison of disease location demonstrated highly significant differences among studies.
|
17131470 |
2006 |
Ileal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We show a significant association of ileal involvement with CARD15 variants (OR = 1.8; p = 0.02), HLA-DRB1*0701 (OR = 1.9; p = 0.006) and DRB1*04 (OR = 1.7; p = 0.02) alleles and demonstrate the capacity of combined CARD15 and HLA-DRB1 genotyping to predict ileal disease in CD patients.
|
15046222 |
2004 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
NOD2/CARD15 variants were significantly associated with ileal disease (chi2=4.5; p=0.03; OR=5; 95% CI=0.9-35.9).
|
14638352 |
2003 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
NOD2 mutations were highly associated with CD and stricturing behavior (P < .0001), with the p.1007fs mutation also conferring a risk for isolated ileal disease (P = .003).
|
20713205 |
2010 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease, stricturing disease behavior in Hungarian CD patients.
|
15770725 |
2005 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CARD15 gene variants have been identified as a major genetic risk factor for CD patients and associated with ileal disease, stenosis, and risk of surgery.
|
19638967 |
2009 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
LHGDN |
These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease, stricturing disease behavior in Hungarian CD patients.
|
15770725 |
2005 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In a Spanish population from Madrid, mutations of the NOD2/CARD15 gene were a marker of susceptibility to Crohn disease and were associated with ileal disease.
|
14750643 |
2003 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genotype-phenotype analysis demonstrated that CARD15 variants were associated with ileal disease (p=0.0006, OR = 9.3, CI = 2.2-34) and protective for colonic CD (p = 0.01, OR = 0.18).
|
16716969 |
2006 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
After correction for age and smoking, CARD15 mutations were strongly associated with both ileal disease (P=8.8 x 10(-6)) and stenotic disease (P=0.003), but the association with stenotic disease appeared to be due to a confounding effect with ileal disease.
|
18090989 |
2008 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, in the multivariate analysis for stricturing disease applying a non-hierarchical criteria, ileal disease (OR, 4.19; 95% CI: 1.30-13.5; P = 0.01), and carrying both NOD2/CARD15 variants and the 4G/4G PAI-1 genotype (OR, 5.02; 95% CI: 1.44-17.48; P = 0.01) were independent predictive factors.
|
17269998 |
2007 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The ASCA titer (odds ratio (OR): 2.7 per 25 U, 95% confidence interval (CI): 1.5-46.7) and ileal disease were associated with stricturing/penetrating behavior, independently of NOD2/CARD15 status.
|
17206688 |
2007 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Remarkably, all patients with a CARD15 mutation and positive anti-S. cerevisiae antibody had ileal disease.
|
14971813 |
2004 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Carriage of CARD15 variants and smoking as risk factors for resective surgery in patients with Crohn's ileal disease.
|
16167972 |
2005 |
Ileal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest a role for NOD2 in the regulation of Paneth cell mediated responses against intestinal bacteria and a plausible mechanism to explain the selective association of NOD2 mutations with ileal disease.
|
14570728 |
2003 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Rapid progression is associated with ileal disease and positive ASCA, and delayed progression is associated with variant NOD2/CARD15 alleles.
|
15472511 |
2004 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The association of the SLC22A -TC haplotype and CARD15 alleles with ileal disease suggests that these variants have biologically intertwined effects in the pathogenesis of CD.
|
15685536 |
2005 |
Ileal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
NOD2/CARD15 was associated with ileal involvement, while presence of TNF-863A was inversely associated with ileal disease (OR = 0.42, p= 0.008) and positively associated with isolated colitis (OR = 2.16, p= 0.008, OR = 2.12, p= 0.03 corrected) and familial disease (p= 0.004).
|
15667501 |
2005 |
Ileal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association with at least 1 NOD2/CARD15 variant was specific for ileal disease (with or without colonic involvement).
|
20380008 |
2010 |