|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The data suggest that IBD1 may also contribute to susceptibility to ulcerative colitis, and that it is likely to be located in the 12 cM interval between D16S419 and D16S409.
|
9541106 |
1998 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results are consistent with the presence of a major gene in the IBD1 region close to D16S408 involved in both UC and CD.
|
11093274 |
2000 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
This microsatellite marker for IBD1, when combined with other markers, has the potential to be used as a screening tool for colorectal cancer and dysplasia in patients with UC.
|
10807284 |
2000 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interpretation The insertion mutation in the NOD2 gene confers a substantially increased susceptibility to Crohn's disease but not to ulcerative colitis.
|
11425413 |
2001 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data demonstrate the association of the IBD1 locus with both ulcerative colitis and Crohn's disease in a group of unrelated IBD patients.
|
11318544 |
2001 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we report the mutational analyses of CARD15 in 453 patients with CD, including 166 sporadic and 287 familial cases, 159 patients with ulcerative colitis (UC), and 103 healthy control subjects.
|
11875755 |
2002 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The new information summarized here includes: the discovery of the association of the NOD2 gene with Crohn's disease; the role of bacteria and the modulating effects of probiotics; the inverse association of appendectomy and ulcerative colitis; progress in imaging based on magnetic resonance imaging and leukocyte scintigraphy; assessment of the value of anti-Saccharomyces cerevisiae antibodies in the screening of inflammatory bowel disease and differentiation between ulcerative colitis and Crohn's disease; and risk factors and management of dysplasia and cancer.
|
11778131 |
2002 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A case-control study of NOD2 polymorphisms known to be associated with Crohn's disease (CD) (Pro(268)Ser, Arg(702)Trp, Gly(908)Arg, and Leu(1007)fsinsC) was performed in 229 cases of primary AS with no diagnosed inflammatory bowel disease (IBD), 197 cases of AS associated with IBD (referred to as colitic spondylarthritis; comprising 78 with CD and 119 with ulcerative colitis [UC]), and 229 ethnically matched, healthy controls.
|
12115195 |
2002 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The most striking is 16q12 (IBD1), which linked only with CD not UC in the majority of studies.
|
12918095 |
2003 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to delineate the frequency of three missense and one frameshift variant of CARD15 in Israeli Jewish CD and UC patients.
|
12923865 |
2003 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We investigated 198 sporadic CD patients, 46 probands with familial CD, 27 CD probands from mixed IBD families, 99 unrelated patients with ulcerative colitis (UC), and 300 control individuals for the occurrence of the CARD15 gene variants R702W, G908R, and 1007fs.
|
12631669 |
2003 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Fifty five specimens of ileum or colon from 21 CD patients, seven ulcerative colitis (UC) patients, and five controls with pathology other than CD or UC were stained for NOD2 using an immunoperoxidase method.
|
14570728 |
2003 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
LHGDN |
Genetics of inflammatory bowel disease: scientific and clinical implications.
|
12617879 |
2003 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
NOD2 gene 3020insC frameshift mutation is not a major contributor to the susceptibility to both Crohn's disease and ulcerative colitis in Chinese Han patients.
|
15052696 |
2004 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Loci meeting suggestive significance for inflammatory bowel disease were 2q, 3q, 5q, 7q and 16 (NOD2/CARD15 region); Crohn's disease, 2q, 3q, 6p, 16 (NOD2/CARD15 region), 17q, 19p; and ulcerative colitis, 2q.
|
14976156 |
2004 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The carrier prevalence of CARD15 variants for CD patients was 46.3%, compared to 20.6% for healthy controls and 22.0% for ulcerative colitis (UC) patients (both p < 0.0001).
|
15046221 |
2004 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among the candidate genes investigated to date, only CARD15/NOD2 has been definitively associated with Crohn Disease (CD) but not Ulcerative Colitis (UC).
|
15157820 |
2004 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In Crohn's disease patients, 35.6% carried at least one mutant allele of NOD2/CARD15 mutations compared with 14.3% of patients with ulcerative colitis (P = 0.006) and to 15.5% of controls (P = 0.0001).
|
15142196 |
2004 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The carrier prevalence of CARD15 variants for CD patients was 46.3%, compared to 20.6% for healthy controls and 22.0% for ulcerative colitis (UC) patients (both p < 0.0001).
|
15046221 |
2004 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated associations with disease susceptibility, phenotype, and evidence for epistasis with CARD15 in 679 patients with Crohn's disease (CD) or ulcerative colitis (UC).
|
16344054 |
2005 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
LHGDN |
Additionally, 51.67% of the CD patients were carriers of a TLR4 and/or CD14 polymorphic allele and at least one variant of the NOD2/CARD15, compared to 27% of the UC patients.
|
15655821 |
2005 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Forty-four percent of patients with CD were positive for >or=1 mutant allele of NOD2/CARD15 compared to 2% of UC patients (p < 0.001) and 19% of healthy twins (p= 0.02).
|
16279904 |
2005 |
|
Ulcerative Colitis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
Ulcerative Colitis
|
0.700 |
Biomarker
|
disease |
MGD |
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.
|
15692052 |
2005 |