|
Carcinoma, Ovarian Epithelial
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Loss of MKK4 expression in ovarian cancer: a potential role for the epithelial to mesenchymal transition.
|
20309881 |
2011 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
Biomarker
|
disease |
BEFREE |
Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.
|
17276500 |
2007 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In the current study, we investigated the mechanism relating loss of MKK4 expression to the development of ovarian cancer.
|
21487811 |
2011 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, these data support a role for MKK4 in the suppression of metastatic colonization in ovarian cancer.
|
12438272 |
2002 |
|
Central neuroblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Using a combination of screening a library of 65'000 kinase inhibitors and in vitro inhibitor target profiling of the screening hits using the Ambit kinase platform, MKK4 was identified as playing a key role in Tau-S422 phosphorylation in human neuroblastoma cells.
|
21638028 |
2011 |
|
cervical cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the functional -1304G variant in the MKK4 promoter contributes to a decreased risk of cervical cancer by increasing the promoter activity and that the G variant may be a marker for susceptibility to cervical cancer.
|
22335172 |
2012 |
|
Cervix carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the functional -1304G variant in the MKK4 promoter contributes to a decreased risk of cervical cancer by increasing the promoter activity and that the G variant may be a marker for susceptibility to cervical cancer.
|
22335172 |
2012 |
|
Childhood Neuroblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Using a combination of screening a library of 65'000 kinase inhibitors and in vitro inhibitor target profiling of the screening hits using the Ambit kinase platform, MKK4 was identified as playing a key role in Tau-S422 phosphorylation in human neuroblastoma cells.
|
21638028 |
2011 |
|
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overexpression of these genes was significantly associated to a poor response to treatment (P = .0001 and P = .0049, respectively), tumor progression, and worse overall survival (P = .0052 and P = .0085, respectively), suggesting that MAPK7 and MAP2K4 could play an important role in osteosarcoma tumorigenesis.
|
22154052 |
2012 |
|
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This is the first study showing that miR-27a can function as an oncogene by targeting MAP2K4 in the osteosarcoma MG63 cell line.
|
24556602 |
2014 |
|
Childhood Rhabdomyosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings on rhabdomyosarcoma samples showed multiple copy number alterations in chromosome regions implicated in malignancy progression and indicated a strong expression of MAP2K4 and MCL1 genes, both involved in different biological functions of complicated signalling pathways.
|
19012245 |
2009 |
|
Colonic Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
Disruption of signaling through SEK1 and MKK7 yields differential responses in hypoxic colon cancer cells treated with oxaliplatin.
|
18436711 |
2008 |
|
Colorectal Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
These results suggest that CRC patients with low pMKK4 immunochemistry scores should be monitored carefully for early detection of possible recurrences, especially liver metastasis.
|
28423721 |
2017 |
|
Colorectal Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Western blotting analysis showed that the levels of Mkk4 protein in sporadic CRC neoplastic tissues were significantly higher in the carriers of -1304G variant genotypes than that in those with -1304TT genotypes.
|
19610067 |
2009 |
|
Colorectal Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Functional polymorphism MKK4 -1304T>G has been showed to be protective in colorectal cancer or lung cancer.
|
21702039 |
2012 |
|
Colorectal Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis revealed that the <i>MKK4</i> -1304T>G polymorphism could reduce the risk of CRC (G <i>vs</i>.
|
31157265 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
MKK4 was significantly elevated in OA cartilage.
|
29072705 |
2017 |
|
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A functional approach was taken to test the ability of MKK4 to suppress metastatic colonization, the process whereby disseminated cancer cells lodge and grow at a secondary site in vivo.
|
12438272 |
2002 |
|
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with lower MKK4 expression in endometrial cancer tissues tended to have a shorter overall survival (p = 0.197).
|
21372598 |
2010 |
|
Epstein-Barr Virus Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our data suggest that the protective role of genetic variant MKK4 -1304T>G is restrained in NPC with EBV infection.
|
21702039 |
2012 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The largest fold changes (> 1.6) in the S-glutathionylated proteome after fatigue occurred on signaling proteins such as 14-3-3 protein gamma and MAP2K4, as well as proteins like SERCA1, and NDUV2 of mitochondrial complex I, at previously unknown glutathionylation sites.
|
29857311 |
2018 |
|
Fibrosis, Liver
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression levels of genes responsible for liver fibrosis (TGF-α) and cell regeneration (MKK4, MKK7, and ATF2) have been measured by RT-PCR analysis.
|
31418419 |
2019 |
|
Fibrosis, Liver
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Diethylnitrosamine (DEN)-induced liver fibrosis in mice and TGF-β<sub>1</sub>-activated hepatic stellate cells (HSCs) were established and treated with dosage/concentration-graded Sal B and/or MAPK activator (Vacquinol-1: MKK4-specific activator)/inhibitors (PD98059: ERK-specific inhibitor; SP600125: JNK-specific inhibitor; SB203580: p38-specific inhibitor).
|
31678285 |
2019 |
|
Frontotemporal Lobar Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, a specific shut off in mitogen-activated protein kinase kinase 4 (SEK1/MKK4)/stress-activated protein kinase (SAPK) axis was exclusively observed in PSP, whereas a specific phosphoinositide-dependent protein kinase 1 (PDK1) inactivation was observed in FTLD-TDP43.
|
30999060 |
2019 |
|
Gallbladder Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the effects of overexpressed miR-136 by transferring mimics in gallbladder cancer (GBC) and to assess the functional role of miR-136 in GBC cell behaviors with the involvement of the mitogen-activated protein kinase kinase 4 (<i>MAP2K4</i>)-dependent JNK signaling pathway.
|
31369289 |
2019 |