Malignant Testicular Germ Cell Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
BLMH gene SNP A1450G has a significant effect on TC-related survival (log-rank P = .001).
|
18398146 |
2008 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
BMH-21 also decreased MDM2 proto-oncogene expression and increased protein levels of the tumor suppressor p53 and p53 phosphorylated at serine 15 (p‑p53‑Ser15), which contributed to increased expression of the downstream apoptosis-related protein BCL2 associated X (BAX) and activation of caspase-3.
|
28656213 |
2017 |
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Additional studies should be undertaken to increase the confidence that the BH polymorphism is associated with AD and to explore the relationship between BH and apoE.
|
10822352 |
2000 |
Pulmonary Fibrosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Compared with controls, Blmh null mice were more sensitive to acute BLM lethality and developed pulmonary fibrosis more readily following BLM treatment.
|
10200322 |
1999 |
Hodgkin Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Effect of Bleomycin Hydrolase Gene Polymorphism on Late Pulmonary Complications of Treatment for Hodgkin Lymphoma.
|
27327270 |
2016 |
Adult Hodgkin Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Effect of Bleomycin Hydrolase Gene Polymorphism on Late Pulmonary Complications of Treatment for Hodgkin Lymphoma.
|
27327270 |
2016 |
Childhood Hodgkin Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Effect of Bleomycin Hydrolase Gene Polymorphism on Late Pulmonary Complications of Treatment for Hodgkin Lymphoma.
|
27327270 |
2016 |
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Finally, Southern blot analysis of DNA from leukocytes and autologous breast tumors has shown that the bleomycin hydrolase gene is not a frequent target of amplification in human breast carcinomas.
|
9407121 |
1997 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, Southern blot analysis of DNA from leukocytes and autologous breast tumors has shown that the bleomycin hydrolase gene is not a frequent target of amplification in human breast carcinomas.
|
9407121 |
1997 |
Hodgkin Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Frequency distribution of BLMH, XPO5 and HFE gene polymorphisms in the South Indian population and their association with Hodgkin Lymphoma.
|
29683071 |
2018 |
Adult Hodgkin Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Frequency distribution of BLMH, XPO5 and HFE gene polymorphisms in the South Indian population and their association with Hodgkin Lymphoma.
|
29683071 |
2018 |
Childhood Hodgkin Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Frequency distribution of BLMH, XPO5 and HFE gene polymorphisms in the South Indian population and their association with Hodgkin Lymphoma.
|
29683071 |
2018 |
Pulmonary Fibrosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Functional studies of bleomycin hydrolase activity indicate that this enzyme modulates bleomycin-induced pulmonary fibrosis, suggesting that it may be a candidate gene for Blmpf2.
|
12140188 |
2002 |
Germ Cell Cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients.
|
15900213 |
2005 |
Narcolepsy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association database developed in the Japanese Integrated Database Project.
|
19629137 |
2009 |
Dermatitis, Atopic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the transcriptional regulatory mechanisms of BH and the relevance of BH to AD.
|
21190945 |
2011 |
Eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the transcriptional regulatory mechanisms of BH and the relevance of BH to AD.
|
21190945 |
2011 |
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
However, no direct association was observed between the -491A/T or BH-PEN polymorphism and AD.
|
10530514 |
1999 |
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method.
|
21943823 |
2011 |
Liver carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method.
|
21943823 |
2011 |
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In addition, apolipoprotein E gene allele E4 and the bleomycin hydrolase locus are shown to be genetic risk factors for late-onset AD in certain sporadic cases.
|
10230703 |
1999 |
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice lacking Blmh exhibited variably penetrant tail dermatitis that resembled rodent ringtail.
|
10200322 |
1999 |
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
No association was observed between carrying the BLMH-G genotype and AD in ε4 negative or positive subjects.
|
20198498 |
2010 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Recently two novel rRNA synthesis inhibitors, CX-5461 and BMH-21, have been shown to selectively kill cancer cells while sparing normal cells.
|
26061708 |
2015 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Recently two novel rRNA synthesis inhibitors, CX-5461 and BMH-21, have been shown to selectively kill cancer cells while sparing normal cells.
|
26061708 |
2015 |