|
Fleck corneal dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fibroblasts were obtained from the skin biopsies of patients with FCD (n = 2) and controls (n = 2). iPSCs were generated by exposing the fibroblasts to viral vectors that contained the Yamanaka factors (OCT4, SOX2, KLF4, and c-MYC genes) responsible for promoving cell reprogramation.
|
31816405 |
2020 |
|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Though these analogs are not superior than D22 in discriminating among OCTs/PMAT, our findings point to development of compounds with combined ability to inhibit both low-affinity/high-capacity transporters, such as OCT3, and high-affinity/low-capacity transporters, such as SERT, as therapeutics with potentially improved efficacy for treatment of psychiatric disorders.
|
30473490 |
2019 |
|
Ganglioneuroma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that tumours with a high proportion of cells expressing Oct4 correlated statistically with undifferentiated and poorly differentiated neuroblastoma / nodular ganglioneuroblastoma, and that Oct4 expression was not present in ganglioneuroma (p < 0.05).
|
30606139 |
2019 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recombinant plasmid pcDNA3.1-OCT4 was constructed and transferred into ALL MSCs by liposome transfection.
|
31159871 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recombinant plasmid pcDNA3.1-OCT4 was constructed and transferred into ALL MSCs by liposome transfection.
|
31159871 |
2019 |
|
Myeloid Leukemia, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing the OCT4-PG1 pseudogene reduces OCT-4 protein levels and changes characteristics of the multidrug resistance phenotype in chronic myeloid leukemia.
|
30721421 |
2019 |
|
Premature Menopause
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results show that the activity of Hh signaling is decreased in the ovaries in physiological aging and POF models, which is consistent with the trend of expression levels of the germline stem cell markers Mvh and Oct4.
|
31277696 |
2019 |
|
Retinal Detachment
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry (IHC) of retinectomized tissue due to PVR caused by RD was performed to determine presence of markers for microglial cells (CD34), macrophages and activated microglia (CD68), regulator of the immune response to infection (NFkB), progenitor and stem cell marker (Sox2), pluripotency marker (Oct4) and intermediate filament markers (GFAP and Nestin).
|
31185026 |
2019 |
|
Ovarian Failure, Premature
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results show that the activity of Hh signaling is decreased in the ovaries in physiological aging and POF models, which is consistent with the trend of expression levels of the germline stem cell markers Mvh and Oct4.
|
31277696 |
2019 |
|
Small cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The stem cell marker SOX2 was found in all CTC lines and SCLC GLC14/16, whereas elevated expression of Oct-3/4 and Nanog was restricted to BHGc26 and UHGc5.
|
31446534 |
2019 |
|
Niemann-Pick Disease, Type C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, ova inhibited NPC tumorsphere formation, associated with decreased SOX2, OCT4 and JAK-STAT signaling pathway.
|
30668347 |
2019 |
|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Though these analogs are not superior than D22 in discriminating among OCTs/PMAT, our findings point to development of compounds with combined ability to inhibit both low-affinity/high-capacity transporters, such as OCT3, and high-affinity/low-capacity transporters, such as SERT, as therapeutics with potentially improved efficacy for treatment of psychiatric disorders.
|
30473490 |
2019 |
|
Streak gonad
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Undifferentiated gonadal tissue is a non-neoplastic condition resembling a streak gonad but additionally contains germ cells with delayed maturation that express OCT4; however, other germ cells, show normal maturation and express TSPY1.
|
31805291 |
2019 |
|
Metastatic melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
3, 3-diaminobenzidine (DAB) immunohistochemical (IHC) staining of ten samples of MM to the brain demonstrated the expression of the embryonic stem cell (ESC) markers OCT4, NANOG, SALL4, SOX2 and pSTAT3.
|
30626524 |
2019 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study support the high expression of Oct4 and Nanog in ICC implies aggressive tumor behaviors and suggest a poor clinical prognosis, which emerges as valuable biomarkers for identifying patients at high risk after curative resection.
|
30854141 |
2019 |
|
Hereditary hemochromatosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results show that the activity of Hh signaling is decreased in the ovaries in physiological aging and POF models, which is consistent with the trend of expression levels of the germline stem cell markers Mvh and Oct4.
|
31277696 |
2019 |
|
Nijmegen Breakage Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Human fibroblasts cells from a female diagnosed with Nijmegen Breakage Syndrome (NBS) carrying the homozygous NBN c.657_661del5 mutation were used to generate integration-free induced pluripotent stem cells (iPSCs) by over-expressing episomal-based plasmids harbouring OCT4, SOX2, NANOG, KLF4, c-MYC and LIN28.
|
30616142 |
2019 |
|
Ewings sarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Certain bone and soft tissue (BST) tumours harbour a chromosomal translocation [t(6;22)(p21;q12)], which fuses the Ewing's sarcoma (EWS) gene at 22q12 with the octamer-binding transcription factor 4 (Oct-4) gene at 6p21, resulting in the chimeric EWS-Oct-4 protein that possesses high transactivation ability.
|
31155838 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recombinant plasmid pcDNA3.1-OCT4 was constructed and transferred into ALL MSCs by liposome transfection.
|
31159871 |
2019 |
|
Dentatorubral-Pallidoluysian Atrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we report the generation of IBCHi001-A, an induced pluripotent stem cell (iPSC) line derived from DRPLA patient fibroblasts using non-integrative reprogramming technology with OCT4, SOX2, cMYC and KLF4 reprogramming factors.
|
31374462 |
2019 |
|
Poorly Differentiated Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that tumours with a high proportion of cells expressing Oct4 correlated statistically with undifferentiated and poorly differentiated neuroblastoma / nodular ganglioneuroblastoma, and that Oct4 expression was not present in ganglioneuroma (p < 0.05).
|
30606139 |
2019 |
|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, ova inhibited NPC tumorsphere formation, associated with decreased SOX2, OCT4 and JAK-STAT signaling pathway.
|
30668347 |
2019 |
|
Primary cholangiocarcinoma of intrahepatic biliary tract
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of Oct4 and Nanog predict poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection.
|
30854141 |
2019 |
|
Adrenal Cortex Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Co-expression analysis of stem cell (OCT4, SSEA4) and CSC (ALDH1/2, CD44 and LGR5) markers with proliferation marker (KI67) in HG tumors revealed dual positive proliferating stem and CSCs, few non-proliferating stem/CSC (SSEA4<sup>+</sup>/KI67<sup>-</sup> and ALDH1/2<sup>+</sup>/KI67<sup>-</sup>) and only KI67<sup>+</sup> cells in cortex, signifying dynamic populations and interesting cellular hierarchy in cortex region.
|
30121075 |
2018 |
|
Ameloblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Twenty odontogenic keratocysts (OKC), 20 ameloblastomas (AMB) of the solid/multicystic type and 20 adenomatoid odontogenic tumors (AOT) were retrospectively analyzed for immunohistochemical detection of Oct-4 and CD44 in their epithelial component.
|
29971493 |
2018 |