|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients.
|
30867003 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis.
|
30867003 |
2019 |
|
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our insights demonstrate the importance and functional regulation of the HSP90-NAP1 protein complex in cancer metastatic signaling, which spur new avenues to target this interaction as a novel approach to block NSCLC metastasis.
|
30867003 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Mechanistic studies further reveal that the binding of NAP1 to the cellular chaperone heat shock protein 90 (HSP90) is required for its protein stabilization, and NAP1 plays an essential role in HSP90-mediated invasion and metastasis by provoking MMP9 activation and the epithelial-to-mesenchymal transition in NSCLC cells.
|
30867003 |
2019 |
|
Substance abuse problem
|
0.010 |
Biomarker
|
disease |
BEFREE |
Secondary analysis of dbGaP GWAS datasets (Genome-Wide Association Studies based on the database of Genotypes and Phenotypes) revealed significant interactions between regions upstream of <sup>AZI2</sup>3'UTR and SLC6A3 in SUDs.
|
28983843 |
2018 |
|
Thiel-Behnke corneal dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrate, using the Syrian golden hamster model of CDI, that the inclusion of binary toxin components CDTa and CDTb significantly improves the efficacy of the vaccine against challenge with NAP1 strains in comparison to vaccines containing only TcdA and TcdB antigens, while providing comparable efficacy against challenge with the prototypic, non-epidemic strain VPI10463.
|
28125650 |
2017 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we report numerous looping interactions and provide evidence that only a minority of interactions are common to both B- and T-cell lines, suggesting interactions may be highly cell-type specific; some disease-associated SNPs do not interact with the nearest gene but with more compelling candidate genes (for example, FOXO1, AZI2) often situated several megabases away; and finally, regions associated with different autoimmune diseases interact with each other and the same promoter suggesting common autoimmune gene targets (for example, PTPRC, DEXI and ZFP36L1).
|
26616563 |
2015 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Over 75 % of CDIs with NAP1 was hospital-acquired, and more often proceeded with generalized infection (p < 0.05).
|
24213847 |
2014 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, we have revealed an important oncogenic cascade involving FRA-2/JUND and SOX4 in ATL, which leads to the expression of genes such as GCKR, NAP1, and HDAC8.
|
23482931 |
2013 |
|
Low Tension Glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TAP showed that NAP1, TANK and TBKBP1 interact with TBK1 and are good candidates for contributing to NTG.
|
23286385 |
2013 |
|
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Evaluation of the Cepheid Xpert Clostridium difficile Epi assay for diagnosis of Clostridium difficile infection and typing of the NAP1 strain at a cancer hospital.
|
20943860 |
2010 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Evaluation of the Cepheid Xpert Clostridium difficile Epi assay for diagnosis of Clostridium difficile infection and typing of the NAP1 strain at a cancer hospital.
|
20943860 |
2010 |
|
Hypophosphatemia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
It is characterized by renal phosphate wasting, leading to hypophosphatemia and an inappropriately normal or low serum level of 1,25(OH)2 vitamin D. Previous studies have pointed to a circulating factor or phosphatonin-inhibiting phosphate transport by decreasing mRNA of the proximal tubule NaP(i) cotransporter NaPi-2A.
|
15454393 |
2005 |
|
Psoriasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this case, local pharmacologic down-regulation of NAP-1/IL-8 activity could be a promising therapeutic strategy in PS.
|
1711550 |
1991 |
|
Diarrhea
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In a 2009 outbreak of C. difficile-associated diarrhea that was recorded in a major Costa Rican hospital, the hypervirulent NAP1 strain (45%) predominated together with a local genotype variant (NAPCR1, 31%).
|
27165560 |
2016 |
|
Diarrhea
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The dominant 072 ribotype was carried by 43% (12/28) of subjects, while the hypervirulent strain R027 (B1/NAP1/027) was isolated from 3 subjects (11%), 2 of whom displayed C. difficile associated diarrhea (CDAD) symptoms at the time of sampling.
|
22162545 |
2012 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, hNap1BP bound to the SH3 domain of c-Abl and Nck. hNap1BP is expressed ubiquitously in various tissues like human Nap1, and intriguingly these genes are co-expressed in hippocampus and cerebral cortex in mouse brain where AD pathological features are strongly evident.
|
11418237 |
2001 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on these results, the possible role of human Nap1 in AD is discussed.
|
10673335 |
2000 |
|
Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Colonized patients contribute to transmission, but CDI cases are more likely linked to other infected patients than colonized patients in this cohort with high rates of the NAP1/027/ST1 strain, highlighting the importance of local prevalence of virulent strains in determining transmission dynamics.
|
29846557 |
2019 |
|
Clostridium; difficile (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Hypervirulent Strain of Clostridium Difficile: NAP1/B1/027 - A Brief Overview.
|
30967977 |
2019 |
|
Clostridium difficile infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078.
|
30052178 |
2018 |
|
Clostridium difficile infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The increased incidence and severity of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain.
|
29174729 |
2018 |
|
Clostridium difficile infection
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clostridium difficile infections (CDI), particularly those caused by the BI/NAP1/027 epidemic strains, are challenging to treat.
|
30004695 |
2018 |
|
Central Diabetes Insipidus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whole genome sequencing of CA-CDI isolates confirmed that NAP 1-like pulsotypes are commonplace in CA-CDI.
|
30170546 |
2018 |
|
Central Diabetes Insipidus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078.
|
30052178 |
2018 |