|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no relationship between the presence of the variant LH and the clinical and hormonal parameter in the PCOS subjects; however, in the controls the presence of the variant LH was associated with a higher serum total testosterone (P = 0.046), oestradiol (P = 0.03) and SHBG (P = 0.002).
|
7586598 |
1995 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sex hormone-binding globulin levels were lower in women with PCOS and in groups 1 and 3 than those in group N (P < 0.002, P < 0.02, and P < 0.002, respectively) independently of the body mass index.
|
10566641 |
1999 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin is a potent inhibitor of SHBG production in the liver, and there is now evidence that SHBG is a marker of hyperinsulinemia and insulin resistance that can be associated in both obese and non-obese patients with polycystic ovary syndrome.
|
11117669 |
2000 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Women with PCOS presented with higher body-mass index, insulin resistance, T, FT, A, and ACTH-stimulated 17-OHP serum concentrations and lower SHBG serum levels, as compared with controls.
|
11334920 |
2001 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PCOS sisters also had decreased levels of SHBG (P = 0.02) suggestive of higher ambient insulin levels.
|
11994352 |
2002 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum SHBG levels are low in patients with hyperandrogenism, especially in association with polycystic ovarian syndrome (PCOS) and in individuals at risk for diabetes and heart disease.
|
11927624 |
2002 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
The biological variation of testosterone and sex hormone-binding globulin (SHBG) in polycystic ovarian syndrome: implications for SHBG as a surrogate marker of insulin resistance.
|
12679434 |
2003 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Comparing hirsute patients, type 2 17 beta-HSD expression was higher in treated PCOS (3.0+/-0.34 versus 2.2+/-0.13) and IH patients (2.5+/-0.19 versus 2.0+/-0.15); hirsutism score was lower (P=0.003, PCOS; P=0.003, IH); and SHBG levels were higher (P=0.001, PCOS; P=0.024, IH) in treated patients.
|
12957669 |
2003 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our aim was to investigate the possible association of the functional (TAAAA)n polymorphism in the promoter of the SHBG gene with PCOS and its relation to SHBG levels.
|
14671199 |
2003 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Our aim was to investigate the possible association of the functional (TAAAA)n polymorphism in the promoter of the SHBG gene with PCOS and its relation to SHBG levels.
|
14671199 |
2003 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasma SHBG concentration was related to PCOS status, non-SHBG-bound testosterone, BMI, fasting blood glucose level, fasting insulinemia, and D327N allele v. The v allele was associated with higher SHBG levels [36.9 +/- 15.9 nmol/liter for W/v (n = 52) and 43.5 +/- 3.5 nmol/liter for v/v (n = 2)] than was the wild-type W allele [31.1 +/- 16.1 nmol/liter (n = 249); P = 0.039].
|
14764814 |
2004 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We studied 186 women with PCOS who had undergone a standard 75-g oral glucose tolerance test and measurement of serum androgen and SHBG levels.
|
15181086 |
2004 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the G972A variant of IRS-1 may modulate reproduction by lowering sex hormone-binding globulin in both healthy women and women with PCOS.
|
16084882 |
2005 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS.
|
16757555 |
2006 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that women with PCOS have a high incidence of genomic instability, and this condition is positively correlated with the hirsutism score, BMI, LH and serum total testosterone and insulin levels, and is negatively correlated with SHBG.
|
16556719 |
2006 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS.
|
17258903 |
2007 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, the D327N polymorphism of the SHBG gene does not influence susceptibility to PCOS.
|
17258903 |
2007 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum SHBG levels were significantly lower (P < 0.001) in PCOS patients compared with controls and were found to be strongly influenced by the (TAAAA)(n) SHBG polymorphism, in both the PCOS (55.3%) and control (33.1%) groups of patients.
|
17189294 |
2007 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Long SHBG(TAAAA)n alleles (>8 repeats) were at greater frequency in PCOS than normal women (P = 0.001), whereas short AR(CAG)n alleles (<or=20 repeats) tended to be more frequent in PCOS women than controls.
|
18192296 |
2008 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our aim was to examine the role of the sex hormone-binding globulin (SHBG) and androgen receptor (AR) gene polymorphisms, in the phenotypic expression of PCOS.
|
18192296 |
2008 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
The aim of this study was to examine whether the sex hormone binding globulin (SHBG)(TAAAA)n and the cytochrome P450, family 19 (CYP19)(TTTA)n polymorphisms, known to influence sex hormone-binding globulin (SHBG) levels and aromatase activity respectively, play a synergistic role in the development of PCOS.
|
18505907 |
2008 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to examine whether the sex hormone binding globulin (SHBG)(TAAAA)n and the cytochrome P450, family 19 (CYP19)(TTTA)n polymorphisms, known to influence sex hormone-binding globulin (SHBG) levels and aromatase activity respectively, play a synergistic role in the development of PCOS.
|
18505907 |
2008 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the TAAAAn polymorphism in SHBG gene was not a determinant of PCOS in this population of Chinese women, whereas, serum SHBG was significantly associated with BMI and insulin resistance in these PCOS patients.
|
18937076 |
2009 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, multiple studies in women with PCOS confirm that certain genetic polymorphisms are associated with circulating SHBG levels, but they are not consistently associated with PCOS per se.
|
21178921 |
2010 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the effects of the SHBG (TAAAA)(n) and androgen receptor gene [AR] (CAG)(n) allele length on endocrine-metabolic features and body composition (by dual-energy X-ray absorptiometry) before and after 1 year on metformin (850 mg/d) in 70 girls with polycystic ovary syndrome after precocious pubarche; allele lengths were assessed by polymerase chain reaction in both patients and in population control subjects (n = 107).
|
20691435 |
2010 |