|
Acute lymphocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in other folate related genes (MTRR, MTR [MS], TYMS [TS], SLC19A1 [RFC1], NNMT, and SHMT1) are less clearly associated with susceptibility to ALL, and the number of included studies on this subject in this review is limited.
|
19775302 |
2010 |
|
Acute lymphocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, polymorphisms in the folate-related genes MTHFR, MTRR, and SHMT1 are related to MTX resistance in pediatric patients with ALL.
|
15797993 |
2005 |
|
Acute lymphocytic leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
Adenocarcinoma
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Association of MTHFR C677T and SHMT(1) C1420T with susceptibility to ESCC and GCA in a high incident region of Northern China.
|
17206530 |
2007 |
|
Adenocarcinoma of lung (disorder)
|
0.330 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-198 suppressed proliferation of lung adenocarcinoma cells both in vitro and in vivo by directly targeting SHMT1. miR-198 may be a potential therapeutic target for lung adenocarcinoma in the near future.
|
26553359 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
0.330 |
Biomarker
|
disease |
BEFREE |
In conclusion, we demonstrate that hsa_circ_0025036 regulates cell proliferation and apoptosis in lung adenocarcinoma cells probably via hsa_circ_0025036/miR-198/SHMT1&TGF-α axis. hsa_circ_0025036 may serve as a potential prognostic biomarker and a therapeutic target for lung adenocarcinoma.
|
30138108 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.330 |
Biomarker
|
disease |
BEFREE |
miR-218-5p was enhanced and SHMT1 was inhibited in NK cells of LA patients, whereas stimulation of interleukin-2 (IL-2) reversed their abundances.
|
31124332 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.330 |
Biomarker
|
disease |
CTD_human |
c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma.
|
27602772 |
2016 |
|
Adenoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence.
|
17113224 |
2007 |
|
Adenoma of large intestine
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins.
|
17113224 |
2007 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
In conclusion, polymorphisms in the folate-related genes MTHFR, MTRR, and SHMT1 are related to MTX resistance in pediatric patients with ALL.
|
15797993 |
2005 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Further, MS 2756AG individuals who were SHMT1 1420CT/TT had a 5.6-fold reduction in ALL risk (OR = 0.18; 95% CI, 0.05-0.63).
|
11986237 |
2002 |
|
Adult Acute Lymphocytic Leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in thymidylate synthase (TS) 28-bp tandem repeats in the promoter region and in cytosolic serine hydroxymethyltransferase (SHMT1 C1420T) have been reported to modulate the risk of adult acute lymphocytic leukemia (ALL).
|
12604405 |
2003 |
|
Adult Non-Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
|
26666829 |
2015 |
|
Adult Solid Neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Published data regarding the association between the cytosolic serine hydroxymethyltransferase (SHMT1) C1420T (Leu474Phe) polymorphism and solid tumor risk have shown inconclusive results.
|
26125758 |
2015 |
|
Adverse reaction to drug
|
0.300 |
Biomarker
|
group |
CTD_human |
Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis.
|
21064136 |
2011 |
|
Alopecia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
ATIC 347GG was associated with gastrointestinal side effects (OR 3.0, P < 0.01), while TSER*2/*2 (OR 5.4, P < 0.01) and SHMT1 1420CC (OR 3.2, P < 0.01) were associated with alopecia.
|
16447238 |
2006 |
|
Anaplastic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Stromal SHMT1 expression was highest in AC (62.5 %) and absent in all FC (p < 0.001).
|
27277113 |
2016 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MTHFR C677T is a risk factor, whereas MTRR A66G and SHMT C1420T polymorphisms reduce risk for autism.
|
19440165 |
2009 |
|
Bladder Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Because these dietary factors are involved in the one-carbon metabolism pathway, we evaluated associations between bladder cancer risk and 33 single nucleotide polymorphisms (SNPs) in 8 genes (CBS, CTH, MTHFR, MTR, MTRR, SHMT1, SLC19A1 and TYMS) and interactions with dietary variables involved in this pathway.
|
17311259 |
2007 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Breast Carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Conversely, for women over 50, the risk of breast cancer development was statistically associated with the MTHFR 677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of cSHMT C1420T (P = 0.0120) and the protective effect associated with the RFC1 G80A polymorphism allele (P = 0.0021), was restrict to this age group.
|
22134752 |
2012 |
|
Breast Carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
In the subgroup analysis based on ethnicity, SHMT1 C1420T polymorphism has shown a protective effect on breast cancer in Asians (T vs. C, OR = 0.78, 95 % CI = 0.66-0.93) but not in Caucasian (T/T vs. C/C, OR = 0.98, 95 % CI = 0.86-1.12).
|
24789272 |
2014 |
|
Breast Carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan.
|
17595805 |
2007 |