|
Epilepsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel non-sense and inactivating variant of ST3GAL3 in two infant siblings suffering severe epilepsy and expressing circulating CA19.9.
|
31584066 |
2020 |
|
Oral Cavity Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The study demonstrated significant role of elevated mRNA levels of ST3GAL2 and ST3GAL3 in disease progression and metastasis of oral carcinoma.
|
31747460 |
2020 |
|
Malignant neoplasm of mouth
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Higher mRNA levels of ST3GAL2 and ST3GAL3 were significantly associated with advanced stage of the disease, lymph node involvement and perineural invasion, which denote their role in progression and metastasis of oral cancer.
|
31747460 |
2020 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The study demonstrated significant role of elevated mRNA levels of ST3GAL2 and ST3GAL3 in disease progression and metastasis of oral carcinoma.
|
31747460 |
2020 |
|
Congenital Disorders of Glycosylation
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Three missense variants of ST3GAL3 are known to be responsible for a congenital disorder of glycosylation determining a neurodevelopmental disorder (intellectual disability/epileptic encephalopathy).
|
31584066 |
2020 |
|
Neurodevelopmental Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Three missense variants of ST3GAL3 are known to be responsible for a congenital disorder of glycosylation determining a neurodevelopmental disorder (intellectual disability/epileptic encephalopathy).
|
31584066 |
2020 |
|
Ovarian cancer stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our previous studies have shown that high expression of β‑galactoside‑α2,3‑sialyltransferase III (ST3Gal3) in the metastatic ovarian cancer cell line HO8910PM attenuated cisplatin‑induced apoptosis.
|
31702036 |
2019 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
We identified multiple genes and pathways with common or disease specific effects, such as NISCH (P = 9.87 × 10<sup>-3</sup> for BP and 2.49 × 10<sup>-6</sup> for SCZ), ST3GAL3 (P = 1.19 × 10<sup>-2</sup> for ADHD), and KEGG_MAPK_SIGNALING_PATHWAY (P = 1.56 × 10<sup>-3</sup> for ADHD, P = 4.71 × 10<sup>-2</sup> for BP, P = 4.60 × 10<sup>-4</sup> for SCZ).
|
30339835 |
2018 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We then examined the functional effects of ST3Gal3 knockdown in cancer cell lines using FACS analysis.
|
27871859 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
We then examined the functional effects of ST3Gal3 knockdown in cancer cell lines using FACS analysis.
|
27871859 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
ST3Gal III modulates breast cancer cell adhesion and invasion by altering the expression of invasion-related molecules.
|
27779707 |
2016 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ST3Gal III modulates breast cancer cell adhesion and invasion by altering the expression of invasion-related molecules.
|
27779707 |
2016 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knowledge about ST3Gal III could increase our understanding of its function in the occurrence and development of avian influenza.
|
23943396 |
2013 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We, therefore, comparatively analyzed the content of CD75s-gangliosides and closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4GlcNAc sequence) and the gene expression of associated β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) and β-galactoside α-2,3-sialyltransferase 6 (ST3GAL6), respectively, in 35 hepatocellular carcinoma (HCC) patients.
|
21147760 |
2011 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In summary, the overexpression of ST3Gal III in these pancreatic adenocarcinoma cell lines underlines the role of this enzyme and its product in key steps of tumour progression such as adhesion, migration and metastasis formation.
|
20824144 |
2010 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
ST3Gal III overexpressing pancreatic adenocarcinoma cell lines Capan-1 and MDAPanc-28 were generated.
|
20824144 |
2010 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer.
|
12931020 |
2003 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
ST3GAL-III and ST6GAL-I activity showed no independent prognostic relevance in multivariate analysis, but high levels of ST3GAL-III and ST6GAL-I in the tumor tissue correlated with secondary local tumor recurrence (p = 0.005; p = 0.012).
|
12931020 |
2003 |
|
Recurrent tumor
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
ST3GAL-III and ST6GAL-I activity showed no independent prognostic relevance in multivariate analysis, but high levels of ST3GAL-III and ST6GAL-I in the tumor tissue correlated with secondary local tumor recurrence (p = 0.005; p = 0.012).
|
12931020 |
2003 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer.
|
12931020 |
2003 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggested that ST3Gal III and ST6Gal I were of importance for the lymph node metastases in FIGO IB1 cervical cancer patients; more specifically, overexpression of ST6Gal I was of crucial relevance for the presence of poor prognostic factors, such as deep stromal invasion and lymph-vascular space involvement and lymph node metastases.
|
12079299 |
2002 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A combination of enhanced ST6Gal I mRNA expression and decreased mRNA expression from ST3Gal I, ST3Gal III, and ST3Gal IV might be important in cervical cancer.
|
11585423 |
2001 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ST6Gal I expression was enhanced in squamous cell carcinoma of the cervix (P = 0.026, Mann-Whitney U test), but mRNA expression from the other three STs (ST3Gal I, ST3Gal III, and ST3Gal IV) was significantly down-expressed in squamous cell carcinoma of the cervix compared to the normal cervix (P = 0.003, P < 0.001, and P = 0.001, respectively).
|
11585423 |
2001 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A combination of enhanced ST6Gal I mRNA expression and decreased mRNA expression from ST3Gal I, ST3Gal III, and ST3Gal IV might be important in cervical cancer.
|
11585423 |
2001 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gene structure and transcriptional regulation of human Gal beta1,4(3) GlcNAc alpha2,3-sialyltransferase VI (hST3Gal VI) gene in prostate cancer cell line.
|
11587543 |
2001 |