Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.010 Biomarker disease BEFREE Chromosomal aberrations included several chromosomal translocations involving breakpoints at 9p21, 14q11.2, 14q32.1, or 16q23.1, suggesting the involvement of WWOX, TCL gene cluster, and BCL11B, which are crucial for tumorigenesis in T-cell lymphomas. 22819381 2012
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.010 Biomarker group BEFREE The current study demonstrates that removal of Bcl11b at the double-positive stage of T cell development or only in T(reg) cells causes IBD because of proinflammatory cytokine-producing CD4(+) T cells infiltrating the colon. 21875956 2011
CUI: C0018939
Disease: Hematological Disease
Hematological Disease 		0.010 GeneticVariation group BEFREE Aberrations of BCL11B locus leading to abnormal gene transcription were identified in human hematological disorders and corresponding animal models. 20824091 2010
CUI: C0005699
Disease: Blast Phase
Blast Phase 		0.010 Biomarker disease BEFREE These results indicate that Bcl11b and H2AX function as tumor suppressor and that haploinsufficiency and acquired loss of these gene products cooperate with p210BCR/ABL to develop CML BC. 19432895 2009
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 Biomarker disease BEFREE These results indicate that Bcl11b and H2AX function as tumor suppressor and that haploinsufficiency and acquired loss of these gene products cooperate with p210BCR/ABL to develop CML BC. 19432895 2009
CUI: C0027533
Disease: Neck Neoplasms
Neck Neoplasms 		0.010 AlteredExpression group BEFREE A statistically significant increase in the expression of CTIP2 was detected in the poorly differentiated samples of the human head and neck tumors. 19399189 2009
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.010 AlteredExpression disease BEFREE CTIP2 expression was found to be significantly elevated in HNSCC (p<0.01), and increase in CTIP2 expression was associated with poorly differentiated tumor status. 19399189 2009
CUI: C0376544
Disease: Hematopoietic Neoplasms
Hematopoietic Neoplasms 		0.010 Biomarker group BEFREE The B-cell chronic lymphocytic leukemia (CLL)/lymphoma 11B gene (BCL11B) encodes a Krüppel-like zinc-finger protein, which plays a crucial role in thymopoiesis and has been associated with hematopoietic malignancies. 17173069 2007
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 Biomarker disease BEFREE CTIP2 complexes that were isolated from SK-N-MC neuroblastoma cells were found to harbor substantial histone deacetylase activity, which was likely conferred by the nucleosome remodeling and deacetylation (NuRD) complex. 16950772 2006
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 Biomarker disease BEFREE CTIP2 complexes that were isolated from SK-N-MC neuroblastoma cells were found to harbor substantial histone deacetylase activity, which was likely conferred by the nucleosome remodeling and deacetylation (NuRD) complex. 16950772 2006
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 Biomarker disease BEFREE CTIP2 complexes that were isolated from SK-N-MC neuroblastoma cells were found to harbor substantial histone deacetylase activity, which was likely conferred by the nucleosome remodeling and deacetylation (NuRD) complex. 16950772 2006
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE BCL11B is a homolog to BCL11A (2p13), a highly conserved gene implicated in mouse and human leukemias. 15104287 2004
CUI: C0023452
Disease: Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia 		0.010 GeneticVariation disease BEFREE A cryptic chromosome rearrangement, t(5;14)(q35.1;q32.2), recently identified in pediatric acute lymphoblastic leukemia (ALL), targets activation of TLX3 at 5q35.1 by juxtaposition with a region downstream of BCL11B at 14q32.2. 14500364 2003
CUI: C0265344
Disease: Donohue Syndrome
Donohue Syndrome 		0.010 Biomarker disease BEFREE Here we report the prenatal diagnosis of leprechaunism in one consanguineous family, Atl-1, in which two homozygous-affected siblings died with leprechaunism. 8606887 1995
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.010 Biomarker phenotype BEFREE However, fibroblasts cultured from a patient with intrauterine growth restriction and severe insulin resistance (leprechaun Atl-1) had normal amounts of insulin receptor protein and defective insulin binding but constitutive activation of insulin-receptor autophosphorylation and kinase activity and of glucose transport. 8419945 1993
CUI: C0004096
Disease: Asthma
Asthma 		0.020 Biomarker disease BEFREE MiR-133a-3p-EFHD2/CNN2-AC144831.1 interactions and miR-3613-3p-CD44/BCL11B-LINC00158/CTA-217C2.1/AC010976.2/RP11-641A6.2 interactions were speculated to involve with the development of severe asthma. 30426778 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.020 GeneticVariation group BEFREE Consequently, T<sub>reg</sub>-specific ablation of Bcl11b results in marked breakdown of immune tolerance, leading to aggressive systemic autoimmunity. 31457081 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.020 Biomarker group BEFREE Bcl11b prevents fatal autoimmunity by promoting T<sub>reg</sub> cell program and constraining innate lineages in T<sub>reg</sub> cells. 31457080 2019
CUI: C1535926
Disease: Neurodevelopmental Disorders
Neurodevelopmental Disorders 		0.020 GeneticVariation group BEFREE This is the first report of NDD caused by a BCL11B variant in a Chinese population. 31347296 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.020 Biomarker disease BEFREE We found significantly decreased Bcl11b but increased IL-17A and TGF-β1 expression in patients with asthma and a strongly negative correlation between Bcl11b and these 2 cytokines in SA patients. 30088373 2018
CUI: C0018889
Disease: Helminthiasis
Helminthiasis 		0.020 Biomarker disease BEFREE Publisher Correction: Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. 30026604 2018
CUI: C0018889
Disease: Helminthiasis
Helminthiasis 		0.020 Biomarker disease BEFREE Here we report that mice lacking Bcl11b in mature T-cells have a diminished capacity to mount Th2 responses during helminth infection and allergic asthma, showing reduced Th2 cytokines and Gata3, and elevated Runx3. 29700302 2018
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas 		0.020 Biomarker group BEFREE Here, we show that the transcription factor B cell lymphoma 11b (Bcl11b), a previously unknown component of GATA3 transcriptional complex, is involved in GATA3-mediated gene regulation. 29514917 2018
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.020 Biomarker disease BEFREE Publisher Correction: Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. 30026604 2018
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.020 Biomarker disease BEFREE Here we report that mice lacking Bcl11b in mature T-cells have a diminished capacity to mount Th2 responses during helminth infection and allergic asthma, showing reduced Th2 cytokines and Gata3, and elevated Runx3. 29700302 2018