|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The norepinephrine transporter occupancy at week 2 in hypothalamus but not in other regions predicted improvement in depression as reflected by reduction in MADRS scores from baseline to week 7.
|
29016993 |
2018 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Then, we analyzed the expression of NET correlation with inflammatory cytokines to provide a new direction for detecting the association mechanism between depression and hypertension.
|
30957546 |
2020 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that DNA methylation levels of nine CpG sites in NET gene promoter region are not associated with depression and hypertension.
|
28737436 |
2017 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, we found two genes, SLC6A4 and SLC6A2, to be the main therapeutic targets, and Serotonin-Norepinephrine Reuptake Inhibitors (SNRI) and Tricyclic Antidepressants (TCA) to be the most effective drugs for individuals with depression at risk for suicide.
|
29331709 |
2018 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The NET and 5-HT1A polymorphisms appear to have similar effects on hippocampal volume in patients and controls while the 5-HTTLPR polymorphism differentially affects hippocampal volume in the presence of depression.
|
25990886 |
2015 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD.
|
18973248 |
2009 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results favor the hypothesis that monoaminergic neurotransmission in general and the F528C NET and R219L 5-HT(1A) receptor variants in particular are involved in the pathogenesis of depression.
|
19105200 |
2009 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter belongs to the family of sodium-chloride coupled neurotransmitter transporter and is related to depression in humans.
|
31442583 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results from our study do not suggest SLC6A2 as a susceptibility gene for depression in the Danish population.
|
23969988 |
2013 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It was shown that the NET-T182C, interacting with 5-HTTLPR, was associated with the susceptibility to depression.
|
19468717 |
2009 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since NE signaling contributes to diverse brain functions, we hypothesize that promoter variation within the human NET gene (solute carrier family 6, member 2; SLC6A2) may impact risk for NE-related disorders, including depression, attention deficit hyperactive disorder (ADHD), and autonomic dysfunction.
|
18591486 |
2008 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The authors tested norepinephrine transporter availability in patients with major depressive disorder with the aim to identify any associations between test results and clinical symptoms.
|
27631962 |
2017 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study attempted to examine the relationship between polymorphisms of NET gene and MD.
|
26061302 |
2015 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that the investigated polymorphisms in the NET gene are not major risk factors in increasing susceptibility to either major depression or its clinical subtypes in a Han Chinese population.
|
17353941 |
2007 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The norepinephrine transporter gene modulates the relationship between urban/rural residency and major depressive disorder in a Chinese population.
|
19564048 |
2009 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The NET T-182C polymorphism may be in part related to the pathophysiology of major depressive disorder in a Japanese population.
|
15539861 |
2004 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between T-182C, G1287A polymorphism in NET gene and suicidality in major depressive disorder in Chinese patients.
|
29703117 |
2018 |
|
Unipolar Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that the NET gene is unlikely to be involved in the susceptibility to major depression.
|
10512149 |
1999 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that the combined effect of rs2242446 and rs5569 in the NET gene could modify the response to the negative life events in triggering MD.
|
18779921 |
2008 |
|
Unipolar Depression
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Methylation of the SLC6a2 gene promoter in major depression and panic disorder.
|
24312678 |
2013 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between norepinephrine transporter T-182C polymorphism and major depressive disorder: a meta-analysis.
|
24374057 |
2014 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: a meta-analysis.
|
23648227 |
2013 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI Study.
|
26960194 |
2016 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
252 unrelated Caucasian patients (f = 142; m = 110) with major depression were genotyped for NET and 5-HTT polymorphisms.
|
20588071 |
2010 |
|
Unipolar Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The sample comprised 426 patients suffering from unipolar MD as well as 643 healthy control subjects for the variants of the 5-HT(1A) receptor and the NET.
|
19105200 |
2009 |