|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8<sup>+</sup> T Cell Activation via Cross-Presentation in Type 1 Diabetes.
|
31118934 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ARC was harvested and analyzed for IKKβ, NF-κB, PICs, reactive oxygen species (ROS) and NAD(P)H (gp91phox,p47phox) oxidase activitylevels and neuropeptides.Compared with normal rats, T2D rats were characterized by hyperglycaemia, hyperinsulinemia, glucose intolerance, cardiac dysfunction, as well as higher ARC levels of IKKβ, NF-κB, PICs, ROS, gp91phox and p47phox.
|
31671427 |
2019 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SLP76 correlation to RXRα and p47phox were conserved in FAB M2 model and patient subtype but not in general non-APL AML.
|
30570341 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
SLP76 correlation to RXRα and p47phox were conserved in FAB M2 model and patient subtype but not in general non-APL AML.
|
30570341 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that ATPR-induced differentiation and G0/G1 phase arrest in acute promyelocytic leukemia (APL) by repressing EBP50/NCF1 complex to promote the production of ROS, and the results from in vivo experiments were consistent with those from in vitro studies.
|
31254567 |
2019 |
|
Polycystic Ovary Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Regardless of weight class, women with PCOS exhibited lipid-induced increases in leukocytic ROS generation and p47phox mRNA and protein content as well as plasma TBARS compared with lean control subjects.
|
31298704 |
2019 |
|
Rheumatism
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that GTF2I-NCF1 region is associated with susceptibility to multiple autoimmune rheumatic diseases but not with AAV, and the primarily associated variant may be the missense SNP in NCF1.
|
31705128 |
2019 |
|
Systemic Scleroderma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population.
|
31705128 |
2019 |
|
Van der Woude syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Hepatic CYP2E1, neutrophil chemotactic factor (NCF-1), iNOS, and NOX-2 (an NADPH oxidase subunit) levels were increased in response to XLGB treatment, and staining for DMPO nitrone adducts further showed elevated oxidative stress level in XLGB/LPS-treated rats relative to the other experimental groups.
|
31026554 |
2019 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
The regulatory subunits of the NOX complex, NCF1 (p47<sup>phox</sup>) and NCF2 (p67<sup>phox</sup>), are up-regulated during HSC activation contributing to ROS production and liver fibrosis.
|
31442911 |
2019 |
|
Acute Myeloid Leukemia (AML-M2)
|
0.010 |
Biomarker
|
disease |
BEFREE |
SLP76 correlation to RXRα and p47phox were conserved in FAB M2 model and patient subtype but not in general non-APL AML.
|
30570341 |
2019 |
|
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that GTF2I-NCF1 region is associated with susceptibility to multiple autoimmune rheumatic diseases but not with AAV, and the primarily associated variant may be the missense SNP in NCF1.
|
31705128 |
2019 |
|
Fatty Liver Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Myeloid cell-specific deletion of the neutrophil cytosolic factor 1 (Ncf1)/p47<sup>phox</sup> gene, which encodes a component of the NADPH oxidase 2 complex that mediates neutrophil oxidative burst, markedly reduced CXCL1-induced NASH and stress kinase activation in HFD-fed mice.
|
31705800 |
2019 |
|
Adenocarcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
After a 21-day resting period, there was still β-catenin-rich inflammatory infiltration in the Ncf1 mice together with high-grade dysplasia and invasive well-differentiated adenocarcinoma, while in the WT mice, high-grade dysplasia was prominent without malignant invasion and only low inflammation.
|
29867918 |
2018 |
|
Refractory anemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the other hand, immunoblot analysis revealed that co-treatment with RA and resveratrol caused remarkable accumulation of protein levels of gp91-phox (to 4-fold), p22-phox (to 5-fold) and p47-phox (to 4-fold) compared with those of the RA-treatment alone.
|
29183727 |
2018 |
|
Blood Coagulation Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Finally, we show in a murine model of trauma-shock that p47phox knock-out (KO) mice with PMN incapable of generating ROS were protected from inflammatory end-organ injury and activated protein C-mediated coagulopathy.
|
30260475 |
2018 |
|
External exotoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
On day 42 of CiOA, synovitis, cartilage damage, and osteophyte formation in Ncf1** mice were unaltered when compared to WT mice.
|
30195046 |
2018 |
|
Enthesitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Enthesitis was induced by local injection of monosodium urate (MSU) crystals into the metatarsal entheses of wild-type (WT) or oxidative-burst-deficient (<i>Ncf1**</i>) mice.
|
30045841 |
2018 |
|
Osteophyte
|
0.010 |
Biomarker
|
disease |
BEFREE |
On day 42 of CiOA, synovitis, cartilage damage, and osteophyte formation in Ncf1** mice were unaltered when compared to WT mice.
|
30195046 |
2018 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model.
|
28191009 |
2017 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The blood and kidneys were then harvested, Glucose uptake rate, glucose transporter 4 (GULT4) mRNA level, cell membrane GULT4 content and GULT4 expression were measured, the level of serum creatinine and blood urea nitrogen were determined, the activity of superoxide dismutase and inducible nitric oxide synthase, the content of malondialdehyde and nitric oxide, reactive oxygen species (ROS) production and nuclear factor κB (NF-κB) mRNA level, Bcl-2 assaciated x protein (Bax) mRNA and B cell lymphoma/lewkmia-2 (Bcl-2) mRNA level, and the expression of protein 47kDa phagocyte oxidase (p47phox) in renal tissues were measured.
|
28482291 |
2017 |
|
Lung Diseases, Interstitial
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We report a 16-year-old patient with CGD caused by homozygous deletion of NCF1 who atypically presented with ILD.
|
28224353 |
2017 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the impact of the NADPH oxidase protein p47phox, which negatively regulates IL-12 in dendritic cells, on colon cancer development in a colitis-associated colon cancer model.
|
28191009 |
2017 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Since myogenic contractions are enhanced by superoxide but impaired by hydrogen peroxide, we tested the hypothesis that they are counterregulated by superoxide and H<sub>2</sub>O<sub>2</sub> from NOX2/p47phox and/or NOX4/POLDIP2 in CKD.
|
28396118 |
2017 |
|
Neointimal hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, HMGB2 enhanced neointimal hyperplasia in mice and proliferation and migration in human aortic smooth muscle cells by inducing reactive oxygen species through increased p47phox phosphorylation.
|
28183701 |
2017 |