|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection.
|
31648581 |
2019 |
|
BLV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings provide insights for BLV infection and for developing new strategies for treating BLV and preventing its spread.-Bai, L., Sato, H., Kubo, Y., Wada, S., Aida, Y. CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection.
|
31648581 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
STAT3 Targets <i>ERR-α</i> to Promote Epithelial-Mesenchymal Transition, Migration, and Invasion in Triple-Negative Breast Cancer Cells.
|
31427441 |
2019 |
|
Malignant neoplasm of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for attained age, sex, birth year, body mass index and pack-years smoked, we found no association between thyroid dose and thyroid cancer risk (ERR/100 mGy = -0.05, 95% CI <-0.10, 0.34).
|
29355960 |
2018 |
|
Bronchitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two definitions of CB using CAT 1/2 scores and SGRQ questions were used to phenotype CB among the study patients.
|
29942122 |
2018 |
|
Coughing
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The present study defined CB using CAT 1 and 2 scores and the questions on the severity of cough and sputum from the SGRQ.
|
29942122 |
2018 |
|
Thyroid Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for attained age, sex, birth year, body mass index and pack-years smoked, we found no association between thyroid dose and thyroid cancer risk (ERR/100 mGy = -0.05, 95% CI <-0.10, 0.34).
|
29355960 |
2018 |
|
Bicuspid aortic valve
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BAV TAA samples showed an increased concentration of putrescine and spermidine vs. TAV and donor samples, together with a decreased mRNA level of polyamine anabolic enzymes and of the putative polyamine transporter SLC7A1/CAT-1.
|
29147966 |
2018 |
|
Thyroid carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for attained age, sex, birth year, body mass index and pack-years smoked, we found no association between thyroid dose and thyroid cancer risk (ERR/100 mGy = -0.05, 95% CI <-0.10, 0.34).
|
29355960 |
2018 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we show in large in silico patient cohorts that paediatric sarcomas and brain tumours express predominately the arginine transporter SLC7A1 and the arginine metabolising enzyme Arginase 2 (ARG2), but have low-absent expression of OTC.
|
28969007 |
2017 |
|
Muscle Rigidity
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Previous reports indicated that L<sup>300</sup>R mutation (LRR mutant) in E<sup>354</sup>R/Arg<sup>356</sup> double mutant (ERR mutant) from Lampyris turkestanicus luciferase has increased its thermal stability and rigidity through induction of some ionic bonds with Asp 270 and 271.
|
28322945 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we found that CAT-1 protein levels were higher in HBV-related HCC carcinomatous tissues than in para-cancerous tumor tissues, and that CAT-1 promoted HCC cell growth, proliferation, and metastasis.
|
28977838 |
2017 |
|
Erythema
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These analyses established that the most important drivers for Cat 1 Classification are (1) CO mean ≥ 3 (days 1-3) (severity) and (2) CO persistence on day 21 in the absence of severity, and those for Cat 2 classification are (3) CO mean ≥ 1 and (4) conjunctival redness mean ≥ 2.
|
26997338 |
2017 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ERR for MI (MI-ERR) in 2011.
|
28445559 |
2017 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that CAT-1 protein levels were higher in HBV-related HCC carcinomatous tissues than in para-cancerous tumor tissues, and that CAT-1 promoted HCC cell growth, proliferation, and metastasis.
|
28977838 |
2017 |
|
Gestational Diabetes
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Insulin also reversed the GDM-associated increase in hCAT-1 protein abundance and mRNA expression, and SLC7A1 promoter activity for the fragment -606 bp from the transcription start point.
|
26710791 |
2016 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also transfected the colon cancer cell line HCT-116 with siRNA specific for the Arg transporter CAT-1 and measured the induction of apoptosis by flow cytometry and cell proliferation by MTT assay.
|
24040099 |
2013 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Quantitative RT-PCR showed that the CAT-1 gene was highly overexpressed in 70.5% of colorectal cancer tissue samples relative to adjacent normal colon tissues in all 122 patients with colorectal cancer.
|
24040099 |
2013 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also transfected the colon cancer cell line HCT-116 with siRNA specific for the Arg transporter CAT-1 and measured the induction of apoptosis by flow cytometry and cell proliferation by MTT assay.
|
24040099 |
2013 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Quantitative RT-PCR showed that the CAT-1 gene was highly overexpressed in 70.5% of colorectal cancer tissue samples relative to adjacent normal colon tissues in all 122 patients with colorectal cancer.
|
24040099 |
2013 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we show that ∼95% of cervical tumor samples examined overexpress Cat-1, suggesting that the up-regulation of Cat-1 expression is a frequent occurrence in this type of cancer.
|
22807447 |
2012 |
|
Tuberculosis, Pulmonary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ninety-eight patients had clinical features suggestive of pulmonary tuberculosis (PTB) and out of them, 22 were new smear positive PTB (CAT I DOTS), 48 smear positive re-treatment, defaulters and CAT I failure PTB (CAT II DOTS) and 28 new smear negative PTB (CAT III).
|
21237291 |
2011 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
ERR receptors as potential targets in osteoporosis.
|
20674386 |
2010 |
|
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To search for miRNAs that may be involved in the pathogenesis of Parkinsons disease (PD), we utilized miRNA microarrays to identify potential gene expression changes in 115 annotated miRNAs in PD-associated Caenorhabditis elegans models that either overexpress human A53T alpha-synuclein or have mutations within the vesicular catecholamine transporter (cat-1) or parkin (pdr-1) ortholog.
|
20091141 |
2010 |
|
Skin lesion
|
0.010 |
Biomarker
|
group |
BEFREE |
In the present study, we characterized the distribution of human cationic amino acid transporters 1 (hCAT1) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry.
|
18172665 |
2008 |