|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, sodium taurocholate cotransporting polypeptide (NTCP) was identified as a functional receptor for human hepatitis B virus (HBV) infection of primary human and Tupaia hepatocytes.
|
23596296 |
2013 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Knockdown analysis suggested that HBV infection of HepG2-hNTCP-C4 cells was mediated by NTCP.
|
24342612 |
2014 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
NTCP also functions as a cellular receptor for viral entry of hepatitis B virus (HBV) and hepatitis D virus (HDV) through a specific interaction between NTCP and the pre-S1 domain of HBV large envelope protein.
|
24390325 |
2014 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that although human NTCP is a functional receptor that mediates HBV infection in human cells, it cannot support HBV infection in mouse hepatocytes.
|
24509445 |
2014 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, sodium taurocholate cotransporting polypeptide (NTCP) was identified as an HBV entry receptor and enabled the establishment of a susceptible cell line that can efficiently support HBV infection.
|
24557582 |
2014 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the association of the functional polymorphism c.800C>T (rs2296651" genes_norm="6554">p.S267F) (rs2296651) of the NTCP gene with HBV infection.
|
24735529 |
2014 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The up-regulation of NTCP expression and restoration of hepatocyte-like polarity in our hydrogels also shed light on future study of hepatitis B virus infection in vitro.
|
24857292 |
2014 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, this study aimed to investigate the association of NTCP polymorphisms with HBV natural course in humans.
|
25010264 |
2014 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inhibition of NTCP uptake may potentially also prevent hepatitis B virus (HBV) infection.
|
25220493 |
2015 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
CTD_human |
However, how host factors regulate the ability of NTCP to support HBV infection is largely unknown.
|
25550158 |
2015 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide.
|
26378168 |
2015 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent studies have demonstrated an essential role of sodium-taurocholate cotransporting polypeptide as a functional receptor in HBV infection, which has facilitated the development of novel infection systems and opened the way for more detailed understanding of the early steps of HBV infection as well as a potential new therapeutic target.
|
26414381 |
2016 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent advances in our understanding of HBV biology, such as the discovery of the bile-acid pump sodium-taurocholate cotransporting polypeptide (NTCP) as a receptor for HBV, enabled the establishment of NTCP expressing hepatoma cell lines permissive for HBV infection.
|
26784218 |
2016 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide.
|
26865711 |
2016 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A genetic variant of the NTCP gene is associated with HBV infection status in a Chinese population.
|
26968990 |
2016 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Examination of SNPs in NTCP for their specific associations with the course of HBV infection in other ethnic minority groups is now required.
|
27051045 |
2016 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
NTCP-targeted therapy has potential for regulating HBV infection in patients with chronic hepatitis B.
|
27278060 |
2016 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance.
|
27491457 |
2016 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
IgG antibodies from BM32-vaccinated but not of HBV-infected individuals recognized the sequence motif implicated in NTCP (sodium-taurocholate co-transporting polypeptide)-receptor interaction of the hepatitis B virus and inhibited HBV infection.
|
27568223 |
2016 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we conducted targeted genetic screening in combination with chemical inhibition to identify the cellular DNA polymerase(s) responsible for cccDNA formation, and exploited recombinant HBV with capsid coding deficiency which infects HepG2-NTCP cells with similar efficiency of wild-type HBV to assure cccDNA synthesis is exclusively from de novo HBV infection.
|
27783675 |
2016 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
HepG2-NTCP cells could also be used to identify chemicals targeting key steps of the virus life cycle including HBV covalent closed circular (ccc) DNA, and enable the development of novel antivirals against the infection.Many factors may contribute to the efficiency of HBV infection on HepG2-NTCP cells, with clonal differences among cell line isolates, the source of viral inoculum, and infection medium among the most critical ones.
|
27975303 |
2017 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
The recent discovery of sodium taurocholate cotransporting polypeptide as the key hepatitis B virus (HBV) and HDV cell entry receptor has opened the door to a new therapeutic era.
|
28121714 |
2017 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, N-glycosylation is required for efficient NTCP localization at the plasma membrane and subsequent HBV infection and these characteristics are preserved in NTCP carrying a single carbohydrate moiety.
|
28125599 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status.
|
28125961 |
2017 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes.
|
28195359 |
2017 |