|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Manganese superoxide dismutase (SOD2) catalyzes the dismutation of superoxide radicals, a major type of ROS, into hydrogen peroxide. p53 is a tumor suppressor gene, and X-ray cross-complementing group 1 (XRCC1) is involved in the base-excision repair of ROS-induced DNA damage.
|
15534883 |
2004 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This work suggests that manipulations that inhibit peroxide removal should enhance the tumor suppressive effect of MnSOD overexpression.
|
10919671 |
2000 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, we identify miR-146a as a potential tumor suppressor in patients with EOC. miR-146a downregulates the expression of SOD2 and enhances ROS generation, leading to increased apoptosis, inhibition of proliferation, and enhanced sensitivity to chemotherapy.
|
27131313 |
2016 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, we identify miR-146a as a potential tumor suppressor in patients with EOC. miR-146a downregulates the expression of SOD2 and enhances ROS generation, leading to increased apoptosis, inhibition of proliferation, and enhanced sensitivity to chemotherapy.
|
27931283 |
2016 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, higher levels of tumor MDA, Mn-SOD protein expression and urinary 8-epi-PGF2α were observed along with lower tumor CAT activity in poorly differentiated or undifferentiated (grade 3, G 3) versus well or moderately well differentiated (grade 1-2, G 1-2) serous EOC tumors.
|
28884887 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
SOD2 plays crucial roles in the tumor-initiating features that are related to TMZ resistance.
|
31629402 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Tamoxifen enhancement of TNF-alpha induced MnSOD expression: modulation of NF-kappaB dimerization.
|
12032862 |
2002 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The tumor cannot be completely eradicated only with ZD55-MnSOD, although ZD55-MnSOD has obvious antitumor activity.
|
17632733 |
2008 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2).
|
11853549 |
2002 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of manganese superoxide dismutase (SOD2), which regulates cellular ROS, is markedly down-regulated in CRPC when compared with hormone-responsive tumors.
|
18829485 |
2008 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, restoration of SOD2 could rescue tumor suppression role of miR-509-5p on breast cancer tumorigenesis.
|
28925482 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Complete sequencing of the two Mn-SOD expression forms unambiguously characterizes this enzyme from a tumor cell line providing evidence that can be used for generation of antibodies and allowing conformational studies.
|
19676086 |
2009 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Enforced expression of MnSOD reverses the malignant phenotype of many transformed cells, suggesting that SOD2 is a tumor suppressor.
|
10463060 |
1999 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Superoxide dismutase 2 (SOD2) was found to exert tumour suppressive effect in basic research, but increased SOD2 protein level was associated with higher aggressiveness of human astrocytomas.
|
29862858 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Male and female mice receiving 1.0 Gy TBI showed radiation-induced life shortening after 120 days that was decreased by MnSOD-PL administration and that was not associated with an increase in rate of tumor-associated death.
|
19024650 |
2008 |
|
Neoplasms
|
0.400 |
Therapeutic
|
group |
CTD_human |
Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2).
|
11853549 |
2002 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Manganese superoxide dismutase (Mn-SOD or SOD2) is a key antioxidant enzyme and was assigned several roles in tumor biology.
|
19676086 |
2009 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These results suggest that overexpression of MnSOD gene is involved in the suppression of spontaneous apoptosis, without a resultant alteration in the tumor growth.
|
10769628 |
2000 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Transfection of SOD-2 in M12 cells markedly decreased tumor growth, apoptosis, G1 delay in the cell cycle, and expression of senescence associated beta-galactosidase.
|
12592389 |
2003 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These results suggest that levels of MnSOD are highly regulated within C8161 melanoma cells and that SOD2 does not suppress tumor formation nor metastatic potential in all human melanomas.
|
8572603 |
1996 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In direct support of these findings, the tumor promoting effects of Cav-1 deficient fibroblasts could be functionally suppressed (nearly 2-fold) by the recombinant over-expression of SOD2 (superoxide dismutase 2), a known mitochondrial enzyme that de-activates superoxide, thereby reducing mitochondrial oxidative stress.
|
21150282 |
2011 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Taken together, our results indicate that MnSOD serves as a biomarker of cancer progression and acts as critical regulator of tumour cell metabolism.
|
25651975 |
2015 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The Oncomine database confirmed higher MnSOD mRNA expression in ccRCC than in normal tissues, and immunohistochemistry analysis revealed that MnSOD protein expression was inversely associated with pathologic grade, clinical stage, tumor size, M status, and cancer-specific survival.
|
29935195 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In the present study, we report that constitutive TrkAIII expression in human SH-SY5Y NB cells inhibits Rotenone, Paraquat and LY83583-induced mitochondrial free radical reactive oxygen species (ROS)-mediated death by stimulating SOD2 expression, increasing mitochondrial SOD2 activity and attenuating mitochondrial free radical ROS production, in association with increased mitochondrial capacity to produce H2O2, within the context of a more tumour stem cell-like phenotype.
|
24736663 |
2014 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In recent studies, decreased expression of Mn SOD, an intramitochondrial enzyme responsible for the dismutation of anion superoxide, has been reported in multiple, malignant cell types, whereas its gene has been proposed as a tumour suppressor gene in melanoma.
|
9649709 |
1998 |