|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the eIF4E-Sox2 axis is a novel mechanism of unregulated self-renewal of glioma-initiating cells, providing a potential therapeutic target for glioma.
|
20537983 |
2010 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that the glioma neurosphere cells positively expressed stem cell marker SOX2, neuroectodermal stem cell marker Nestin, and also expressed astrocytes marker GFAP and neurons marker β-tubulin III fter FBS-induced differentiation for a week, which proved the glioma neurosphere cells have the self-renewal and multipotential differentiation capacity.
|
28592121 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NOS2 expression in glioma cell lines and glioma primary cell cultures: correlation with neurosphere generation and SOX-2 expression.
|
28424427 |
2017 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both forced SOX2 expression and OPA1 inactivation increased LN319 glioma cell invasion in vitro and promoted cell dispersion in vivo in xenotransplanted D. rerio embryos.
|
30403311 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MALAT1 enhanced glioma stem cell viability and proliferation abilities and promoted glioma tumorigenesis through suppressing miR-129 and facilitating SOX2 expressions.
|
29808528 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells.
|
28654819 |
2017 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and flow cytometry analysis of 12 tumor samples obtained from patients with high grade gliomas revealed that a considerable population (2-19%) of cells in all malignant gliomas expressed IL-17RA, with remarkable co-expression of the glioma stem cell (GSC) markers CD133, Nestin, and Sox2.
|
26755664 |
2016 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
And, the ectopic expression of Sox2 attenuated the apoptotic effect of As(2)O(3) on glioma cell.
|
21703238 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOX2 protein expression in glioma cell lines and tumour tissues was verified by Western blot and immunofluorescence.
|
17375044 |
2007 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Accumulating evidence shows that SOX2 is overexpressed in several human tumors, including lung cancer, esophageal carcinoma, pancreatic carcinoma, breast cancer, ovarian carcinoma and glioma.
|
26001828 |
2015 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The glioma stem cells obtained from CD133+ cells demonstrated increased expression of Twist1 and Sox2 accompanied by significant increase in the mesenchymal markers such as N-cadherin, vimentin and β-catenin.
|
22184289 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOX2 expression and amplification in gliomas and glioma cell lines.
|
21518820 |
2011 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a spontaneous mouse model of glioma, ectopic expression of the IE1 gene (UL123) specifically increased Sox2 and Nestin levels in the IE1-positive tumors, upregulating stemness and proliferation markers in vivo.
|
26239477 |
2015 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we concluded that the G9a-dependent H3K9me2 repression on CD133 and Sox2 was one of the main switches of the self-renewal in glioma cancer stem cells.
|
24833465 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure.
|
31267022 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further explore the role of Sox2, we performed in vitro analysis with brain tumor stem cells (BTSCs) and established glioma cell lines.
|
22069467 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Author Correction: Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop.
|
30903095 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also show that, in glioma-initiating cells, Oct4 is associated with Sox4 and that Oct4-Sox4 complexes cooperatively activate the enhancer activity of the SOX2 gene.
|
21987575 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>Sox2-V5</i> and <i>Sox2-mCherry</i>); and (4) engineering of glioma mutations (<i>TP53</i> deletion; <i>H3F3A</i> point mutations).
|
28096221 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that Sox21 can negatively regulate Sox2 in glioma.
|
20824710 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we aim to explore the role of SOX2 for glioma malignancy in particular its role in cell proliferation and migration.
|
22070920 |
2011 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, these findings highlight the role of FHL3 as a stemness-suppressor in regulation of the Smad2/3-SOX4-SOX2 axis in glioma.
|
29955125 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For cases with SOX2 high expression in the primary glioma, those had SOX2 low expression after recurrence seemed to have worse prognosis as compared to patients with stable SOX2 high expression (PFS: 10.4 vs. 14.9 months, p = 0.036; OS: 27.0 vs 49.5 months, p = 0.005).
|
31718604 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop.
|
30559479 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NEAT1 negatively regulated the expression of miR-132 in glioma while miR-132 targeted SOX2 to down-regulate its expression.
|
30053878 |
2018 |