Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In this review, we will describe the role of systemic, tumor-derived, and stroma-derived OPN, highlighting its pivotal role at the crossroads of inflammation and tumor progression.
|
28769537 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer.
|
26509489 |
2015 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here, we use genetic approaches to systematically investigate the function of the RGD domain in different OPN isoforms on tumor progression and metastasis for 2 different solid tumor models.
|
20224789 |
2010 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Extensive studies have elucidated the critical role of OPN in cell signaling such as regulation of cell proliferation, migration, inflammation, fibrosis and tumor progression.
|
27570486 |
2016 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression in various tissues.
|
30177680 |
2018 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma.
|
16739096 |
2006 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Recent clinical studies have indicated that OPN expression is associated with tumor progression and poor prognosis among patients with lung cancer.
|
17482311 |
2007 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
There is growing evidence to suggest that osteopontin (OPN) may play a critical role in tumor progression and metastasis.
|
27578008 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin, a secreted glycoprotein, plays a role in cell survival, immunity, and tumor progression, its expression being associated with a poor prognosis and metastasis in several malignancies.
|
25824779 |
2015 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The gene for the secreted integrin-binding protein osteopontin was most consistently differentially expressed in conjunction with tumor progression.
|
11929952 |
2002 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is identified as a diagnostic and prognostic biomarker of tumor progression and metastasis.
|
31792339 |
2019 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The metastasis gene osteopontin is alternatively spliced only in transformed cells, and the variants promote tumor progression.
|
30542698 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In various adult neoplasms OPN was shown to correlate with cancer progression, invasiveness and metastasis.
|
28326824 |
2017 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is a phosphoprotein that activates several aspects of tumor progression.
|
26404131 |
2016 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
OPN is a cytokine and cell attachment protein which has been implicated in human tumor progression and metastasis, the calcium binding 126MRP protein is related to the human S100 protein family involved in invasive cell growth, and the Rac2 protein belongs to the Rho family of small GTPases regulating actin reorganization and cell migration.
|
16491116 |
2006 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
In the present study, we focused on the therapeutic role of osteopontin (OPN), a secreted glycosylated phosphoprotein, involved in a number of physiological events including bone formation and remodeling, immune responses, and tumor progression.
|
29110207 |
2018 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is one of important molecular targets in cancer progression, metastasis as a calcium-binding, extracellular-matrix-associated protein of the small integrin-binding ligand and, N-linked glycoprotein.
|
25345853 |
2014 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, cell survival and tumor progression.
|
16208410 |
2005 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin is a secreted, integrin-binding and phosphorylated acidic glycoprotein, which has an important role in tumour progression.
|
19901966 |
2010 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Finally, we show that OPN is expressed in senescent stroma within preneoplastic lesions that arise following 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate treatment of mice, suggesting that stromal-derived OPN-mediated signaling events affect neoplastic progression.
|
19155301 |
2009 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN), a secreted phosphoglycoprotein, has been strongly associated with tumor progression and aggressive cancers.
|
17227585 |
2007 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Osteopontin (OPN) is a promoter for tumor progression.
|
29535539 |
2018 |
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
However, little is known about the impact of OPN polymorphisms on cancer progression.
|
23079960 |
2013 |
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The role of osteopontin in tumor progression and metastasis in breast cancer.
|
17548669 |
2007 |
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
OPN is upregulated in human colon cancers, and is suggested to enhance cancer progression.
|
28505114 |
2017 |