Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of CTR, BSP and OPN may prove to be a useful marker for breast cancers, and their role in the homing of breast cancer cells to bone remains to be investigated.
|
9399657 |
1997 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We examined OPN levels in tumors from 154 patients with LNN breast cancer who were followed for a median of 7 years (range 1.7-16.3 years).
|
9761120 |
1998 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Osteopontin (OPN) has been associated with enhanced malignancy in breast cancer, but its functional role in this disease is poorly understood.
|
10435636 |
1999 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Despite its abundance in carcinomas, BSP expression was not detected in a panel of 11 human breast cancer cell lines (MCF-7, T47D, SK-Br-3, MDA-MB-453, MDA-MB-231, MDA-MB-436, BT549, MCF-7ADR, Hs578T, MDA-MB-435, and LCC15-MB) and OPN expression was detected only in two of these (MDA-MB-435 and LCC15-MB).
|
10418827 |
1999 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Osteopontin (OPN) is a secreted glycophosphoprotein which induces migration of mammary carcinoma cells, and has been implicated in the malignancy of breast carcinoma.
|
10861844 |
2000 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study suggests that breast cancer cells that have metastasized to bone may have a survival advantage resulting from interaction of alphavbeta3 on these cells with the bone protein osteopontin.
|
11078811 |
2000 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We observed differential gene expression of the selected TGF-beta family members as well as OPN in breast cancer progression.
|
12206515 |
2002 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Osteopontin expression is related to urinary stone formation and several diseases associated with calcification such as atherosclerosis, breast cancer, and meningioma.
|
12142743 |
2002 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Microcalcifications of breast cancer and atypical cystic lobules associated with infiltration of foam cells expressing osteopontin.
|
11889596 |
2002 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis.
|
11801541 |
2002 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of OPN and TSP-1 may play a role in the pathogenesis of breast cancer.
|
12927044 |
2003 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that increased expression of the alpha(v)beta(3) integrin during breast cancer progression can make tumor cells more responsive to malignancy-promoting ligands such as OPN and result in increased tumor cell aggressiveness.
|
14517343 |
2003 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein that has been implicated in breast cancer.
|
12606946 |
2003 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significantly elevated expression levels were observed for BSP in cancer of the breast, colon, stomach, rectum, thyroid, and kidney; OPN in cancer of the breast, uterus, colon, ovary, lung, rectum, and thyroid; DMP1 in cancer of the breast, uterus, colon, and lung; and dentin sialophosphoprotein in breast and lung cancer.
|
15623631 |
2004 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study we report that OPN induces alpha(v)beta(3) integrin-mediated c-Src kinase activity in both highly invasive (MDA-MB-231) and low invasive (MCF-7) breast cancer cells.
|
14704150 |
2004 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the presence of these transcription factors in human breast cancer is responsible in part for the overexpression of OPN that, in turn, is implicated in mammary neoplastic progression and metastasis.
|
14990565 |
2004 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The 21NT tumorigenic human breast cancer cell line was examined for regulation of CD44 expression at both the mRNA and protein levels in response to an engineered increase in OPN expression under CMV promoter control.
|
16691370 |
2005 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we studied genes regulated by OPN in a model of human breast cancer using oligonucleotide microarray technology by comparing the gene-expression profiles of 21NT mammary carcinoma cells transfected to overexpress OPN versus mock-transfected control cells.
|
15864800 |
2005 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To assess the role(s) of OPN in breast carcinoma, expression of endogenous OPN was knocked down in metastatic MDA-MB-435 human breast carcinoma cells using RNA interference.
|
16830223 |
2006 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.
|
16807238 |
2006 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In human primary breast cancer, BRCA1 mutation is significantly associated with OPN overexpression.
|
16807234 |
2006 |
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we show that breast cancer cells express multiple splice variants of osteopontin.
|
16288209 |
2006 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Osteopontin that associates with metabolism of calcium is one of the important factors in the development and prognosis of human breast cancer.
|
17089001 |
2006 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Stable long-term depletion, or up-regulation, of OPN gene expression in a matched, isogenic pair of human breast cancer cell lines of differing metastatic proficiency reproducibly changed their ability to colonize distant organs.
|
17620367 |
2007 |
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review will focus on the role of OPN in breast cancer, in particular on the malignancy-promoting aspects of OPN that may reveal opportunities for new approaches to the clinical management of breast cancer.
|
17721886 |
2007 |