Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Primary tumor tissue (paraffin-embedded) from 845 patients with small classical cN0 PTC who underwent pCND was tested for BRAF mutation.
|
24402044 |
2014 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A total of 59 PTCs from both groups were evaluated for BRAF mutation on tumor tissue and on ctDNA from plasma samples by real-time polymerase chain reaction (PCR) and digital PCR.
|
29566452 |
2018 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We identified 14 hits whose silencing was able to significantly reduce the viability and the proliferation of TPC1 cells; most of them were active also in BRAF-mutant BCPAP (papillary thyroid cancer) and 8505C (anaplastic thyroid cancer) and in RAS-mutant CAL62 (anaplastic thyroid cancer) cells.
|
27058903 |
2016 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRAF(V600E) was more frequent in PTC with concomitant lymphocytic infiltration.
|
23469895 |
2013 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure.
|
31135058 |
2019 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In this work, we analyzed the expression of PDE5 in a series of human papillary thyroid carcinomas (PTCs) presenting or not BRAF V600E mutation and classified according to ATA risk criteria.
|
25837309 |
2015 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRAF V600E Gene Mutation Is Associated With Bilateral Malignancy of Papillary Thyroid Cancer.
|
30219154 |
2018 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRAF (V600E) mutation was more common in the conventional PTC (38 out of 62; 61%) than in the follicular variant of PTC (2 out of 17; 11.7%).
|
22105775 |
2012 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The objective of the study was to investigate the prognostic value of BRAF mutation in patients with PTC.
|
16174717 |
2005 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In our study, none of the MFT lesions harbored BRAF mutations, whereas 29 % (two of seven) PTCs in the same gland were positive.
|
24337906 |
2014 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRAF mutations were more common in C-PTC (P = 0.002).
|
30352402 |
2018 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
It was significantly associated with extrathyroidal and vascular invasion of FVPTC and FTC and, remarkably, a 50%-60% rate of multifocality and recurrence of BRAF mutation-positive PTC (P = 0.01 and 0.02, respectively).
|
20959410 |
2010 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Thirty-five pediatric PTCs were screened for the most prevalent fusions (RET/PTC1, RET/PTC2, RET/PTC3, ETV6-NTRK3, and AGK-BRAF) and point mutations (BRAF<sup>V600E</sup> and NRAS<sup>Q61</sup>) described in sporadic pediatric PTCs.
|
27849443 |
2017 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (review).
|
22858857 |
2012 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The BRAF V600E mutation rate was high in patients with PTC.
|
28789361 |
2017 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Four of the five patients whose PTC tissues were subjected to microarray analysis were found to carry the BRAF V600E mutation.
|
21179278 |
2010 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We found that numerical changes in BRAF copy number were rare in papillary thyroid carcinomas, while they occurred in 16-45% of follicular tumors of conventional and oncocytic (Hürthle cell) types.
|
16199894 |
2005 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRAF(V600E) status of FNAB cell blocks from 55 patients with PTC was analyzed by immunohistochemistry (IHC) with the new BRAF(V600E) antibody (clone VE1) and by Sanger sequencing (SaS).
|
24039206 |
2014 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Investigation of BRAF mutation in a series of papillary thyroid carcinoma and matched-lymph node metastasis with ARMS PCR.
|
30819583 |
2019 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, BRAF fusions are rare driver alterations in a wide variety of malignant neoplasms, but enriched in Spitzoid melanoma, pilocytic astrocytomas, pancreatic acinar and papillary thyroid cancers.
|
26314551 |
2016 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Activating point mutation of the BRAF gene resulting in V600E (previously designated as V599E) is a common event in thyroid papillary carcinoma, being found in approx 40% of this tumor.
|
16299399 |
2005 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The PTC was positive for the BRAF mutation but negative for RET/PTC1.
|
20369307 |
2010 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to estimate the diagnostic value of BRAF V600E mutation status combined with cytomorphological features for diagnosis of papillary thyroid cancer (PTC) in cytologically indeterminate thyroid nodules.
|
29566402 |
2019 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The analysis of exons 11 and 15 of BRAF gene revealed the T1796A (V599E) mutation in 32% of cases, and this alteration is significantly associated with PTC tall cell variant.
|
15273715 |
2004 |
Papillary thyroid carcinoma
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Papillary thyroid carcinomas (PTC) are the most common type of thyroid malignancy with one of the two mutations, RET/PTC rearrangement or BRAF mutation.
|
18676765 |
2008 |