|
Pilocytic Astrocytoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Pilocytic Astrocytoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Pilocytic astrocytomas: BRAFV600E and BRAF fusion expression patterns in pediatric and adult age groups.
|
31321520 |
2019 |
|
Pilocytic Astrocytoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pilocytic astrocytomas are grade 1 tumors usually occurring in children and young adults with KIAA1549-BRAF fusion defining the majority of pilocytic astrocytomas.
|
31355086 |
2019 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement.
|
31427603 |
2019 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BRAF mutations are new markers found in pilocytic astrocytomas.
|
23278177 |
2013 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BRAF(V600E) mutation was detected in PXA (60%), GG (38.7%), DNT (30%, including 3/11 specific and 3/9 non-specific forms) and PA (12.5%).
|
23442159 |
2013 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BRAF(V600E) was also seen in five of 11 (45%) non-brainstem GGs and one of eight (13%) brainstem PAs.
|
24238153 |
2014 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BRAF mutations are most frequently detected in certain subtypes of low-grade glioma, such as pilocytic astrocytoma (PA), pleomorphic xanthoastrocytoma (PXA), ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNT).
|
27792249 |
2017 |
|
Pilocytic Astrocytoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
BRAF fusion involving the KIAA1549 gene is a hallmark of pilocytic astrocytoma, but it has also been recorded in rare cases of gangliogliomas, 1p/19q co-deleted oligodendroglial tumors, and it is also a common feature of disseminated oligodendroglial-like leptomeningeal neoplasm.
|
29802359 |
2018 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BRAF-V600E mutations are most commonly found in pleomorphic xanthoastrocytoma, ganglioglioma, epithelioid glioblastoma, and gliomas diagnosed at a younger age; BRAF-KIAA1549 fusion is the most common BRAF alteration in pilocytic astrocytoma.
|
30265855 |
2018 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A BRAF V600E mutation was detected in 1 PA, "diffuse variant" case; an IDH1 R132G mutation was found in 1 DA case.
|
22710963 |
2012 |
|
Pilocytic Astrocytoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A Multiplex Quantitative Reverse Transcription Polymerase Chain Reaction Assay for the Detection of KIAA1549-BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pilocytic Astrocytomas.
|
31087282 |
2019 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A single BRAF V600E mutation was identified in the fusion-negative extracerebellar PA of a very young child who succumbed to the disease.
|
24057326 |
2013 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas.
|
30013630 |
2018 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Activating point mutations of BRAF, such as BRAF (V600E), also lead to pilocytic astrocytoma.
|
23439714 |
2013 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Activation of the MAP Kinase (MAPK) pathway caused by the BRAFV600E mutation or the KIAA1549-BRAF fusion has been reported in pediatric GG and PA, respectively.
|
25524464 |
2014 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Adult with cerebellar anaplastic pilocytic astrocytoma associated with BRAF V600E mutation and p16 loss.
|
23196000 |
2013 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although oncogenic rearrangements of the BRAF gene have recently been described in PAs, it is not clear whether such alterations have an impact on outcome.
|
20044755 |
2010 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Among many molecular abnormalities, BRAF mutation and mTOR activation in pilocytic astrocytomas and subependymal giant cell astrocytomas are actionable targets sensitive to vemurafenib and everolimus, respectively.
|
26118895 |
2015 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Aneuploid genomes were identified in 45% of adult compared with 17% of pediatric PA. Gains were non-random, favoring chromosomes 5, 7, 6 and 11 in order of frequency, and preferentially affecting non-cerebellar PA and tumors with BRAF V600E mutations and not with KIAA1549-BRAF fusions or FGFR1 mutations.
|
26378811 |
2015 |
|
Pilocytic Astrocytoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
At a median follow-up of 55 months, the 5-year progression-free survival (PFS) rate for BRAF (V600)-mutant diencephalic low-grade astrocytomas (LGAs) was 22 ± 12 %, shorter than BRAF (V600)-WT PAs (52 ± 13 %) but higher than PMAs (10 ± 6 %).
|
26264609 |
2015 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
B-K fusion in adult PA does not influence outcome, and BRAF V600E mutation appears to be a very rare event.
|
24470550 |
2014 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Besides, more benign brain tumors such as ganglioglioma, dysembryoblastic neuroepithelial tumours and supratentorial pilocytic astrocytomas, only pleomorphic xanthoastrocytomas (50-78%) and epitheloid glioblastoma (50%) regularly exhibit BRAF mutations.
|
29039591 |
2017 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal 7q34 duplication and BRAF-KIAA1549 fusion is a characteristic genetic alteration in pilocytic astrocytomas.
|
22568401 |
2012 |
|
Pilocytic Astrocytoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Chromosome band 7q34 deletions, which resulted in a FAM131B-BRAF fusion, were identified in one pilocytic astrocytoma (PA) and one dysembryoplastic neuroepithelial tumor (DNT).
|
24767714 |
2014 |