Sjogren's Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrated that the functional variant, rs10774671, is associated with HBV infection and anti-SSA antibody-positive SS.
|
29242559 |
2017 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-Ro/SS-A antibodies are commonly found in the sera of patients with Sjögren's syndrome and SLE.
|
1919005 |
1991 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, HLA-DR3 and DRw6 Ro(SS-A) positive SS/LE patients may possess a similar, if not unique, DR region DNA nucleotide sequence involved in disease susceptibility or immune regulation.
|
3262691 |
1988 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have found the Ro (SS-A) antibody with increased frequency in idiopathic thrombocytopenic purpura and thrombocytopenia associated with Sjögren's syndrome, but the nature of the association is unknown.
|
3258497 |
1988 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRIM21 is mainly found in hematopoietic cells in which its expression is induced by IFNs during viral. infections and in systemic autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome.
|
23975864 |
2013 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was a strong correlation between clinical signs and corresponding autoantibodies such as anti-SSA and -SSB antibodies in Sjögren's syndrome (10 cases), antithyroid peroxidase antibodies in thyroiditis and Graves' disease (10 cases), and parietal cell antibodies in gastric ulcers with maltoma (12 cases).
|
10205590 |
1999 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, 87 patients (87%) with anti Ro52+Ro60+ antibodies have autoimmune conditions including Sjögren's syndrome (n=34, 34%), systemic lupus erythematosus (SLE; n=23, 23%), undifferentiated connective tissue diseases (n=12, 12%) and rheumatoid arthritis (n=6, 6%).
|
28663326 |
2018 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study shows that the production of anti-Ro52 autoantibodies in pSS is associated with the DRB1*0301, DRB3*0101, DQA1*0501 and DQB1*0201 alleles which are in strong linkage disequilibrium.
|
11555411 |
2001 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings contrast with the relatively homogeneous immunogenetic background seen in other lupus erythematosus subsets with a high frequency of Ro(SS-A) antibody, i.e., neonatal lupus erythematosus and Sjögren's syndrome/lupus erythematosus overlap (increased frequency of HLA-DR3, DQw2 and DRW52).
|
2031665 |
1991 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, the incidence of antibodies to SS-56 was associated with visceral complications in SLE, and roughly half of the 17 SS or SLE patients with no detectable antibodies to SSA and SSB antigens presented measurable antibodies against recombinant SS-56.
|
11560955 |
2001 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antibodies against Ro52-1 were less frequently found in SSc than in SjS/SLE (11.6 vs. 41.7%, <i>p</i> = 0.001); and antibodies against Ro52-4 were less frequently found in SSc than in SjS/SLE (27.9 vs. 50%, <i>p</i> = 0.03).
|
30581434 |
2018 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The 52 000 MW Ro/SS-A autoantigen in Sjögren's syndrome/systemic lupus erythematosus (Ro52) is an interferon-gamma inducible tripartite motif protein associated with membrane proximal structures.
|
12047754 |
2002 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
SS-A/Ro autoantibodies are detected in high frequency in patients with subacute cutaneous lupus, neonatal lupus, systemic lupus erythematosus, and Sjögren syndrome.
|
8823369 |
1996 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
70 patients with anti-SSA antibody positive SS were selected as the observation group, and the non-positive Sjogren syndrome (PSS) subjects were collected as the control group at the same time.
|
30070316 |
2018 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro52/SSA, also denoted tripartite motif (TRIM)21, is a major autoantigen in Sjögren's syndrome and systemic lupus erythematosus.
|
30178506 |
2018 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.
|
29465352 |
2018 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ro60/SSA is a vital auto antigen that is targeted in Sjogren's syndrome and systemic lupus erythematosus (SLE).
|
29274781 |
2018 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we evaluated immunoreactivity against Ro52-related molecules in SS and healthy volunteers.
|
29463848 |
2018 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA association of anti-Ro60 and anti-Ro52 antibodies in Sjögren's syndrome.
|
7530962 |
1994 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using molecular genetic tools in serologically homogeneous patient populations, and across racial lines, the Ro (SS-A) and la (SS-B) autoantibody responses in systemic lupus erythematosus and Sjögren's syndrome appear to associate most strongly with HLA-DQ alleles, whereas the anti-Jo-1 autoantibody in myositis correlates best with HLA-DRw52.
|
2462349 |
1988 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibodies to Ro52 are present in patients with lupus and Sjögren's syndrome, but it is not known if these autoantibodies affect the function of Ro52.
|
21862588 |
2011 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy.
|
19330707 |
2009 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most patients (n = 28, 93%) presented with many annular erythematous patches and plaques with mild pruritus; 22 (73%) had the SS-A antibody and 17 (57%) met the diagnostic criteria of Sjögren syndrome.
|
28771678 |
2018 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of Ro(SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome.
|
8596150 |
1995 |
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren's syndrome.
|
27460476 |
2016 |