Malignant neoplasm of prostate
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Malignant neoplasm of prostate
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Here, we report the frequency of the 999del5 BRCA2 mutation in an Icelandic control population and four different groups of cancer patients diagnosed with (a) breast cancer; (b) ovarian cancer; (c) prostate cancer (patients younger than 65 years); and (d) other cancer types.
|
8706004 |
1996 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of BRCA2 are predicted to account for approximately 35% of families with multiple case, early onset female breast cancer, and they are also associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer.
|
8988179 |
1997 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of BRCA1 are also associated with ovarian cancer and mutations of BRCA2 are associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer.
|
9134530 |
1997 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Over 2 percent of Ashkenazi Jews carry mutations in BRCA1 or BRCA2 that confer increased risks of breast, ovarian, and prostate cancer.
|
9145676 |
1997 |
Malignant neoplasm of prostate
|
0.900 |
Biomarker
|
disease |
BEFREE |
The risk ratio of prostate cancer was 4.6 (1.9-8.8) in first-degree relatives and 2.5 (1.2-4.6) in second-degree relatives of the 16 BRCA2 positive breast cancer probands.
|
9383000 |
1997 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This study analysed 13q LOH, DNA ploidy, BRCA2 mutation and pRb expression in prostate cancers.
|
9484837 |
1998 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Genes underlying these cancers are now recognized in colorectal cancer (APC, mismatch repair genes, LKB1) and in breast cancer (BRCA1, BRCA2) whereas, in prostate cancer, a locus in chromosome 1 (HPC1) has been proposed on the basis of linkage analysis.
|
9690990 |
1998 |
Malignant neoplasm of prostate
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Normal prostate and 75% (120/160) of prostate-cancer tissue did not express BRCA2 protein.
|
9724085 |
1998 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We tested for the BRCA1 185delAG frameshift mutation, found in 0.9% of Ashkenazi Jews, and the BRCA2 6174delT mutation, found in 1% of Ashkenazi Jews, in Ashkenazi Jewish men with prostate cancer.
|
9743298 |
1998 |
Malignant neoplasm of prostate
|
0.900 |
Biomarker
|
disease |
BEFREE |
These data suggest that microsatellite instability and loss of unidentified genes on chromosome 8p may be involved in carcinogenesis of the prostate; however, BRCA1 and BRCA2 may not be largely involved in the development of prostate cancer in the Japanese population.
|
9778625 |
1998 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Thus, the BRCA-2 locus does not appear to play as important a role in clinically localized prostate cancer as the Rb and/or DBM loci.
|
9815575 |
1997 |
Malignant neoplasm of prostate
|
0.900 |
Biomarker
|
disease |
BEFREE |
Two known tumor suppressor genes, RB1 and BRCA2, map to chromosome 13; however, recent reports suggest that unknown genes on 13q are more likely to be involved in the development of prostate cancer.
|
10337994 |
1999 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Several studies have provided evidence that germline mutations in BRCA1 and BRCA2 confer an increased risk of prostate cancer.
|
10344217 |
1999 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This suggests that unlike cases of breast and ovarian cancers, mutations in BRCA1 or BRCA2 do not significantly predispose men to prostate cancer.
|
10398279 |
1999 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In this study, 22 high-risk prostate cancer families (at least three cases of prostate cancer) were screened by conformation-sensitive gel electrophoresis (CSGE) for mutations in BRCA1 and BRCA2.
|
10728701 |
2000 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Several lines of evidence indicate that germline mutations in BRCA1 and BRCA2 might be associated with an increased risk for CaP.
|
10945492 |
2000 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Blood DNA from affected individuals in 38 prostate cancer clusters was analyzed for germ-line mutations in BRCA1 and BRCA2 to assess the contribution of each of these genes to familial prostate cancer.
|
10969800 |
2000 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of BRCA1 and BRCA2 predispose to hereditary breast, ovarian, and possibly prostate cancer, yet structural mutations in these genes are infrequent in sporadic cancer cases.
|
10972993 |
2000 |
Malignant neoplasm of prostate
|
0.900 |
Biomarker
|
disease |
BEFREE |
Although BRCA2 is probably responsible only for a very small fraction of hereditary prostate cancers, this finding supports previous reports of an increased risk of prostate cancer in BRCA2 mutation carriers.
|
11170288 |
2001 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A second breast cancer susceptibility gene (BRCA2) operates in some of the same molecular pathways as BRCA1, and mutations of this gene predispose to breast and ovarian cancer and probably to other tumor types, including prostate cancer.
|
11405179 |
2001 |
Malignant neoplasm of prostate
|
0.900 |
Biomarker
|
disease |
BEFREE |
The only elevated SIR, besides breast and ovarian, was that for prostate cancer in BRCA2 families (SIR 4.9, 1.8-11).
|
11562114 |
2001 |
Malignant neoplasm of prostate
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Early age at diagnosis of breast cancer, ovarian cancer, bilateral breast cancer, concomitant breast/ovarian cancer in a single patient and prostate cancer but not unilateral breast cancer were associated with BRCA1 and BRCA2 mutations.
|
11802208 |
2002 |