|
ovarian neoplasm
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
|
ovarian neoplasm
|
0.900 |
CausalMutation
|
disease |
CGI |
|
|
|
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
ovarian neoplasm
|
0.900 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The breast cancer susceptibility gene BRCA1 has been cloned and a second susceptibility gene, BRCA2, chromosomally mapped; will most breast and ovarian cancer turn out to be familial?
|
7874485 |
1994 |
|
ovarian neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.
|
8091231 |
1994 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The recent cloning of a breast-ovarian cancer susceptibility gene (BRCA1), and determination of the locus of a related gene (BRCA2), offers potential for clinical genetic testing for breast cancer susceptibility.
|
7677139 |
1995 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRCA1 confers higher risk of ovarian cancer and BRCA2 much higher risk of male breast cancer.
|
8541881 |
1995 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Mutations in BRCA2 are thought to account for as much as 35% of all inherited breast cancer as wall as a proportion of inherited ovarian cancer.
|
8673091 |
1996 |
|
ovarian neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
A role for BRCA2 in sporadic breast and ovarian cancer has been suggested by loss of heterozygosity (LOH) studies which show frequent LOH in the BRCA2 region at chromosome 13q12.
|
8705994 |
1996 |
|
ovarian neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
Our results indicate that BRCA2 confers a very high risk of breast cancer and is responsible for a substantial fraction of breast and ovarian cancer in Iceland, but only a small proportion of other cancers.
|
8706004 |
1996 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
BRCA2 carries a risk of breast cancer similar to that of BRCA1, but is associated with a lower risk of ovarian cancer and a higher risk of male breast cancer.
|
8791478 |
1996 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations of BRCA2 in sporadic breast and ovarian cancer are very rare.
|
8875258 |
1996 |
|
ovarian neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
To define the role of BRCA2 in sporadic breast and ovarian cancer, we screened the entire gene for mutations using a combination of techniques in 70 primary breast carcinomas and in 55 primary epithelial ovarian carcinomas.
|
8640235 |
1996 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Recent studies have identified mutations in the breast and (ovarian cancer susceptibility gene 2 (BRCA2), one which has been found in the germline of several males and one female affected with breast cancer.
|
8758903 |
1996 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The entire 10.2-kb coding region of BRCA2 was screened for mutations in 130 consecutive ovarian tumors, the only selection criterion being a pathological diagnosis of epithelial ovarian carcinoma.
|
8665505 |
1996 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The same BRCA2 mutation appears to be associated with different cancer phenotypes in this population including male and female breast cancer, prostate cancer, pancreas cancer and ovarian cancer.
|
8673089 |
1996 |
|
ovarian neoplasm
|
0.900 |
Biomarker
|
disease |
BEFREE |
The breast:ovarian cancer ratio in these families was 7:1, suggesting BRCA2 confers a much lower risk for ovarian cancer than does BRCA1.
|
8875189 |
1996 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
These BRCA2 families have early-onset breast cancer (mean and median age = 49 years), with four of the eight families including ovarian cancer but with no families including male breast cancer.
|
9150152 |
1997 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Women with BRCA1 or BRCA2 mutations have an increased risk of breast cancer and ovarian cancer.
|
9148160 |
1997 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The tumor suppressor genes BRCA1 and BRCA2, which confer increased susceptibility to breast and (or) ovarian cancer, were recently identified.
|
8990217 |
1997 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Approximately 2% of Ashkenazi Jews carry recurrent germline mutations in either the BRCA1 or BRCA2 genes that may predispose these individuals to the development of breast and ovarian cancer.
|
9360844 |
1997 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of BRCA2 are predicted to account for approximately 35% of families with multiple case, early onset female breast cancer, and they are also associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer.
|
8988179 |
1997 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of BRCA1 are also associated with ovarian cancer and mutations of BRCA2 are associated with an increased risk of male breast cancer, ovarian cancer, prostate cancer and pancreatic cancer.
|
9134530 |
1997 |
|
ovarian neoplasm
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast-ovarian cancer families.
|
9150153 |
1997 |