|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SS18-SSX represents a tumor-specific target in synovial sarcoma.
|
23716114 |
2014 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, SS18-SSX-induced Wnt/β-catenin signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression, representing a potential molecular target for the development of novel therapeutic strategies.
|
24166495 |
2014 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis by reverse transcriptase polymerase chain reaction (RT-PCR) failed to identify the SYT-SSX1 or SYT-SSX2 fusion transcripts characteristic of synovial sarcoma.
|
24966982 |
2014 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling.
|
24228088 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein.
|
24130893 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our new FISH assay has several advantages, including its applicability to paraffin-embedded samples, discrimination of the SS18-SSX1 and SS18-SSX2 translocations particularly in cases with aneuploidy, and potentially detecting translocations in all cases of synovial sarcoma, even with variant translocations.
|
23623359 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the underlying mechanism, we studied human synovial sarcoma (SS), in which transformation results from the translocation of exactly 78 amino acids of SSX to the SS18 subunit of BAF complexes.
|
23540691 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These studies reveal the central role of Wnt/β-catenin signaling in SYT-SSX2-induced sarcoma genesis, and open new venues for the development of effective synovial sarcoma curative agents.
|
23921231 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although precise function of SYT-SSX remains to be investigated, accumulating evidences suggest its role in gene regulation via epigenetic mechanisms, and the product of SYT-SSX target genes may serve as biomarkers of SS.
|
23313505 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reappraisal of TLE-1 immunohistochemical staining and molecular detection of SS18-SSX fusion transcripts for synovial sarcoma.
|
24422953 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma.
|
24022186 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The synovial sarcoma (SS)-associated protein, SYT-SSX2, reprograms myogenic progenitors and human bone marrow-derived mesenchymal stem cells (BMMSCs) by dictating their commitment to a pro-neural lineage.
|
21996728 |
2012 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The RT-PCR detection of SYT-SSX fusion transcripts played a key role in establishing the diagnosis of synovial sarcoma of the cauda equina.
|
22098598 |
2012 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases.
|
22976541 |
2012 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal event generates SS18-SSX fusion transcripts.
|
22439931 |
2012 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first reported case of a remarkable soft tissue sarcoma that exhibits overlapping morphologic features between SS and EMC and that also harbors a combination of SS18-SSX2 and EWS-NR4A3 gene fusions.
|
22743288 |
2012 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study may be valuable for understanding the pathogenic role and molecular mechanism of the fusion gene SYT-SSX in synovial sarcoma through the proposed genome-wide approach.
|
21234732 |
2011 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Synovial sarcoma (SS) is an aggressive soft-tissue malignancy characterized by a unique t(X;18) translocation resulting in expression of SS18-SSX fusion protein.
|
20198325 |
2010 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data suggest that a human multipotent mesenchymal stem cell can serve as a cell of origin for SS and SS is a stem cell malignancy resulting from dysregulation of self-renewal and differentiation capacities driven by SS18-SSX fusion protein.
|
20518020 |
2010 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, compared to SYT-SSX1, SYT-SSX2 was more frequent in Chinese patients with SS.
|
19385976 |
2009 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Novel SYT-SSX fusion transcript variants in synovial sarcoma.
|
19837269 |
2009 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The synovial sarcoma-associated SYT-SSX2 oncogene antagonizes the polycomb complex protein Bmi1.
|
19337376 |
2009 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prospectively, FNAs positive for the SYT-SSX fusion transcript by RT-PCR (n = 6) and, retrospectively, cases proven on histopathology and immunohistochemistry (ICC; positivity for vimentin and epithelial membrane antigen [EMA]/cytokeratin) as SS (n = 10) were included in the study.
|
19267417 |
2009 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the SYT-SSX fusion type is not a significant prognostic factor unlike tumor size, followed by histological grade for patients with localized synovial sarcoma in Japan.
|
18202796 |
2008 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases.
|
18460022 |
2008 |