|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma.
|
7951320 |
1994 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Only by demonstration of the characteristic SYT-SSX gene fusion of synovial sarcoma by reverse transcriptase polymerase chain reaction (RT-PCR) analysis of RNA extracted from archival material could the diagnosis be confirmed.
|
10685642 |
2000 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings indicate possible geographical differences in the frequency of two SYT-SSX fusion transcripts in patients with synovial sarcoma.
|
15350633 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues.
|
9846971 |
1998 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The demonstration of characteristic sequences at the SYT-SSX breakpoint regions is expected to improve our understanding of the molecular genetic mechanisms behind translocations in general, and of the SYT-SSX fusions in synovial sarcoma in particular.
|
12687023 |
2003 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The synovial sarcoma (SS)-associated protein, SYT-SSX2, reprograms myogenic progenitors and human bone marrow-derived mesenchymal stem cells (BMMSCs) by dictating their commitment to a pro-neural lineage.
|
21996728 |
2012 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SS18-SSX chimeric gene is unique to synovial sarcoma.
|
29025595 |
2017 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results reaffirm the specificity of SYT-SSX for SS and suggest that an opposite claim made in a recent study may have been due to a faulty interpretation of the molecular results caused by a contamination of the samples.
|
12004001 |
2002 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The RT-PCR detection of SYT-SSX fusion transcripts played a key role in establishing the diagnosis of synovial sarcoma of the cauda equina.
|
22098598 |
2012 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling.
|
24228088 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nine tumors originally diagnosed as SS were t(X;18) (SYT-SSX)-negative.
|
11172303 |
2001 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we introduce the application of RT in situ PCR to detect a hybrid, SYT-SSX messenger RNA in synovial sarcoma.
|
16861763 |
2006 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, compared to SYT-SSX1, SYT-SSX2 was more frequent in Chinese patients with SS.
|
19385976 |
2009 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The striking spontaneous mesenchymal to epithelial differentiation in this cancer is reminiscent of a developmental switch, but the only clue to its mechanistic basis has been the observation that most cases of synovial sarcoma with glandular epithelial differentiation (GED) contain SYT-SSX1 instead of SYT-SSX2.
|
16849535 |
2006 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We reviewed patients with localized SS; SS18-SSX fusion transcript presence was confirmed by FISH and RT-PCR.
|
25613038 |
2015 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases.
|
18460022 |
2008 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein.
|
24130893 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that SS18/SSX tightly regulates the elevated expression of the key Wnt target AXIN2 in primary SS.
|
26905812 |
2016 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report a cooperative study from the French Sarcoma Group and the Mesopath Group on 40 t(X;18)(SYT-SSX)-positive primary intrathoracic SS.
|
15725802 |
2005 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Synovial sarcoma (SS) is an aggressive soft-tissue malignancy characterized by a unique t(X;18) translocation resulting in expression of SS18-SSX fusion protein.
|
20198325 |
2010 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Synovial sarcoma is associated with a unique translocation, resulting in an SYT-SSX fusion gene.
|
27697479 |
2017 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of our study was to assess microinvasion in a case of synovial sarcoma by means of the reverse transcriptase polymerase chain reaction (RT-PCR) for detecting SYT-SSX fusion transcripts.
|
15045545 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus.
|
10072425 |
1999 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our new FISH assay has several advantages, including its applicability to paraffin-embedded samples, discrimination of the SS18-SSX1 and SS18-SSX2 translocations particularly in cases with aneuploidy, and potentially detecting translocations in all cases of synovial sarcoma, even with variant translocations.
|
23623359 |
2013 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The functional significance of these SS18-like proteins is embodied by the observations that SS18L1 and SS18L2 can replace SS18 in its various protein-protein interactions, and that SS18L1 may act as a fusion partner of SSX in synovial sarcoma.
|
16484776 |
2006 |