|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of the t(X;18) with SSX2 involvement definitively characterizes this tumour as a variant of synovial sarcoma.
|
11207827 |
2001 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of SYT-SSX fusion gene in peripheral blood from a patient with synovial sarcoma.
|
11224613 |
2001 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Coexistence of N-SYT and I-SYT (both fused with SSX) was detected in a series of 59 SSs (35 monophasic and 24 biphasic) and in a SS cell line.
|
11308259 |
2001 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As a result of the synovial sarcoma associated t(X;18) translocation, the human SYT gene on chromosome 18 is fused to either the SSX1 or the SSX2 gene on the X chromosome.
|
11423977 |
2001 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SYT-SSX fusion gene is present in both cellular components of biphasic synovial sarcoma and is involved in oncogenesis of the synovial sarcoma rather than in morphologic epithelial differentiation.
|
11561755 |
2001 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fusions of the SYT and SSX genes in synovial sarcoma.
|
11607825 |
2001 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SYT-SSX fusion genes and prognosis in synovial sarcoma.
|
11720441 |
2001 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To address this issue more definitively, we collected data on SYT-SSX fusion type, pathology, and clinical course in a retrospective multi-institutional study of 243 patients (age range, 6-82) with synovial sarcoma.
|
11782370 |
2002 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results reaffirm the specificity of SYT-SSX for SS and suggest that an opposite claim made in a recent study may have been due to a faulty interpretation of the molecular results caused by a contamination of the samples.
|
12004001 |
2002 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This finding suggests that this novel fusion gene, which involves exon 6 of SSX only, is sufficient to keep the transforming function conferred by the SYT/SSX translocation of SS.
|
12065783 |
2002 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SYT-SSX-dependent expression of cyclin D1 may be an important mechanism in the development and progression of synovial sarcoma and also raises the possibility for targeted therapy.
|
12097301 |
2002 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection and induction of CTLs specific for SYT-SSX-derived peptides in HLA-A24(+) patients with synovial sarcoma.
|
12133991 |
2002 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Detection of SYT-SSX fusion transcripts in paraffin-embedded tissues of synovial sarcoma by reverse transcription-polymerase chain reaction.
|
12150740 |
2002 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive cases.
|
12409719 |
2002 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was designed to evaluate the utility of a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay to detect and distinguish SYT-SSX1 and SYT-SSX2 fusions in fresh and archival specimens of synovial sarcoma in pediatric patients seen at St. Jude Children's Research Hospital.
|
12469233 |
2003 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SYT-SSX2 variant of primary pulmonary synovial sarcoma with focal expression of CD117 (c-Kit) protein and a poor clinical outcome.
|
12683902 |
2003 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The demonstration of characteristic sequences at the SYT-SSX breakpoint regions is expected to improve our understanding of the molecular genetic mechanisms behind translocations in general, and of the SYT-SSX fusions in synovial sarcoma in particular.
|
12687023 |
2003 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Novel fluorescent ligase detection reaction and flow cytometric analysis of SYT-SSX fusions in synovial sarcoma.
|
12707378 |
2003 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increasing evidence suggests that the SYT-SSX fusion gene plays an important role in synovial sarcoma development and progression.
|
14576825 |
2003 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of our study was to assess microinvasion in a case of synovial sarcoma by means of the reverse transcriptase polymerase chain reaction (RT-PCR) for detecting SYT-SSX fusion transcripts.
|
15045545 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SYT-SSX fusion genes in synovial sarcoma of the thorax.
|
15140553 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of the synovial sarcoma-associated t(X;18) or SYT-SSX fusion transcripts may be necessary to confirm the diagnosis of SS in difficult cases.
|
15163010 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SS18-SSX fusions do not seem to occur in other tumor types, and it has been shown that in synovial sarcoma a clear correlation exists between the type of fusion gene and histologic subtype and, more importantly, clinical outcome.
|
15208645 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings indicate possible geographical differences in the frequency of two SYT-SSX fusion transcripts in patients with synovial sarcoma.
|
15350633 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis.
|
15364967 |
2004 |