Malignant Neoplasms
|
0.400 |
GenomicAlterations
|
group |
CGI |
|
|
|
Adenocarcinoma of prostate
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Metastatic melanoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Adenocarcinoma of large intestine
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
COLON CANCER, SUSCEPTIBILITY TO
|
0.100 |
SusceptibilityMutation
|
phenotype |
CLINVAR |
|
|
|
Donohue Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
Another patient with leprechaunism (leprechaun/Ark-1) is a compound heterozygote with two different mutant alleles of the insulin-receptor gene.
|
1968373 |
1990 |
Donohue Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
To clarify the molecular basis of the insulin resistance, we investigated the insulin binding and kinase properties of the insulin receptor and the receptor gene in cultured skin fibroblasts of two patients (Ark-1 and Ark-2) with leprechaunism and in those of three of their parents.
|
2569023 |
1989 |
Donohue Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
Restriction fragment length polymorphisms (RFLPs) for the insulin receptor gene were compared among controls and families Atl and Ark-1, whose probands have extreme insulin resistance and leprechaunism.
|
2574533 |
1989 |
Donohue Syndrome
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Maximal epidermal growth factor (EGF) binding was reduced in fibroblasts from three unrelated patients with leprechaunism (Ark-1, Can-1, and Minn-1) compared with control (0.8-2.2%/mg protein vs. 5.5%/mg protein).
|
2808704 |
1989 |
Donohue Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this study we analyze insulin binding and subunit structure of the insulin receptor in dermal fibroblasts cultured from three unrelated families whose probands (Ark-1, Atl, and Minn) were affected by leprechaunism.
|
3631076 |
1987 |
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines.
|
9174055 |
1997 |
Breast Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines.
|
9174055 |
1997 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
STK15 amplification has been previously detected in breast tumour cell lines and in colon tumours; here, we report its amplification in approximately 12% of primary breast tumours, as well as in breast, ovarian, colon, prostate, neuroblastoma and cervical cancer cell lines.
|
9771714 |
1998 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
STK15 amplification has been previously detected in breast tumour cell lines and in colon tumours; here, we report its amplification in approximately 12% of primary breast tumours, as well as in breast, ovarian, colon, prostate, neuroblastoma and cervical cancer cell lines.
|
9771714 |
1998 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, high expression of STK15 mRNA was detected in tumour cell lines without evidence of gene amplification.
|
9771714 |
1998 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
STK15 amplification has been previously detected in breast tumour cell lines and in colon tumours; here, we report its amplification in approximately 12% of primary breast tumours, as well as in breast, ovarian, colon, prostate, neuroblastoma and cervical cancer cell lines.
|
9771714 |
1998 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
STK15 amplification has been previously detected in breast tumour cell lines and in colon tumours; here, we report its amplification in approximately 12% of primary breast tumours, as well as in breast, ovarian, colon, prostate, neuroblastoma and cervical cancer cell lines.
|
9771714 |
1998 |
Colonic Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
STK15 amplification has been previously detected in breast tumour cell lines and in colon tumours; here, we report its amplification in approximately 12% of primary breast tumours, as well as in breast, ovarian, colon, prostate, neuroblastoma and cervical cancer cell lines.
|
9771714 |
1998 |
Malignant neoplasm of breast
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we have demonstrated that there are three forms of STK-15 gene in breast cancer cell lines.
|
11190269 |
2000 |
Breast Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we have demonstrated that there are three forms of STK-15 gene in breast cancer cell lines.
|
11190269 |
2000 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The differential expression patterns of these alternatively spliced STK15 in breast cell lines and primary tumors therefore suggest that STK15 gene transcription may be differentially regulated or stabilized in these cells.
|
11190269 |
2000 |
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumour-amplified kinase BTAK was recently cloned from breast cancers and mapped on 20q13 as a target gene for this amplification in human breast cancers.
|
11259099 |
2001 |
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that BTAK may be involved in gastric cancer cell aneuploid formation, and is a candidate gene for the increase in the number of copies of the 20q, and thus may contribute to an increase in the malignant phenotype of gastric cancer.
|
11259099 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumour-amplified kinase BTAK was recently cloned from breast cancers and mapped on 20q13 as a target gene for this amplification in human breast cancers.
|
11259099 |
2001 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that BTAK may be involved in gastric cancer cell aneuploid formation, and is a candidate gene for the increase in the number of copies of the 20q, and thus may contribute to an increase in the malignant phenotype of gastric cancer.
|
11259099 |
2001 |