AURKA, aurora kinase A, 6790

N. diseases: 245; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 GenomicAlterations group CGI
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate 		0.300 GenomicAlterations disease CGI
CUI: C0278883
Disease: Metastatic melanoma
Metastatic melanoma 		0.300 GeneticVariation disease UNIPROT
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine 		0.300 GeneticVariation disease UNIPROT
CUI: C4016820
Disease: COLON CANCER, SUSCEPTIBILITY TO
COLON CANCER, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.050 Biomarker disease BEFREE <b>Conclusion:</b> The mRNA signature of AURKA, CDC20 and TPX2 were potential biomarkers for predicting poor prognosis of smoking related lung adenocarcinoma. 30588191 2018
CUI: C0153381
Disease: Malignant neoplasm of mouth
Malignant neoplasm of mouth 		0.020 GeneticVariation group BEFREE <b>Objective:</b> The objective of this study was aimed to investigate the interactions between Aurora kinase A (<i>AURKA</i>) gene polymorphisms (T91A and G169A) and smoking and their effects on the susceptibility of oral cancer. 31174434 2019
CUI: C0220641
Disease: Lip and Oral Cavity Carcinoma
Lip and Oral Cavity Carcinoma 		0.020 GeneticVariation disease BEFREE <b>Objective:</b> The objective of this study was aimed to investigate the interactions between Aurora kinase A (<i>AURKA</i>) gene polymorphisms (T91A and G169A) and smoking and their effects on the susceptibility of oral cancer. 31174434 2019
CUI: C0007124
Disease: Noninfiltrating Intraductal Carcinoma
Noninfiltrating Intraductal Carcinoma 		0.020 AlteredExpression disease BEFREE 344 specific genes, such as FN1, AURKA and HSPA8, were found to be significantly changed (both upregulated and downregulated) in DCIS group in comparison with normal tissue group, which represents the gene profile changes in early stage of breast cancer development. 27506314 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Tumour-amplified kinase BTAK was recently cloned from breast cancers and mapped on 20q13 as a target gene for this amplification in human breast cancers. 11259099 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Tumors with low levels of STK15 amplification (3-4 copies) showed minimal deviation in their chromosome copy number and diploid or near-diploid total nuclear DNA content. 12208897 2002
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 GeneticVariation disease BEFREE Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene Aurora-A/STK15/BTAK. 15688402 2005
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 GeneticVariation disease BEFREE Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene Aurora-A/STK15/BTAK. 15688402 2005
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 GeneticVariation disease BEFREE Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations. 17113223 2007
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 GeneticVariation disease BEFREE Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations. 17113223 2007
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.040 AlteredExpression disease BEFREE HNSCC cells treated with siRNA specific for AURKA were assessed for AURKA mRNA and protein expression levels by reverse transcriptase-polymerase chain reaction and Western blot analysis. 19107951 2009
CUI: C0032927
Disease: Precancerous Conditions
Precancerous Conditions 		0.010 AlteredExpression group BEFREE Premalignant and malignant lesions from the gastric mucosa of patients had increased levels of AURKA protein and nuclear NF-κB, compared with healthy gastric tissue. 23993973 2013
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 GeneticVariation disease BEFREE Breast Cancer Risk Associated with Genotype Polymorphisms of the Aurora Kinase a Gene (AURKA): a Case-Control Study in a High Altitude Ecuadorian Mestizo Population. 28647900 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 GeneticVariation disease BEFREE Breast Cancer Risk Associated with Genotype Polymorphisms of the Aurora Kinase a Gene (AURKA): a Case-Control Study in a High Altitude Ecuadorian Mestizo Population. 28647900 2018
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.090 AlteredExpression disease BEFREE STK15 gene amplification and associated increased expression of the mitotic kinase it encodes are associated with aneuploidy and aggressive clinical behavior in human bladder cancer. 12208897 2002
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.080 Biomarker disease BEFREE STK15 protein was visualized by immunohistochemistry in 205 formalin-fixed, paraffin-embedded human bladder tumors. 12208897 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE STK15 protein expression was also examined in normal pancreatic tissues and tumors by Western blotting and immunohistochemistry. 12631597 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.400 Biomarker group BEFREE STK15 is considered a potential cancer susceptibility gene owing to its functions in normal cell mitosis. 15271853 2004
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE STK15 is considered a potential cancer susceptibility gene owing to its functions in normal cell mitosis. 15271853 2004
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.090 AlteredExpression disease LHGDN STK15 mRNA was found overexpressed in 10 of the 15 ovarian cancer cell cultures. 15839305 2005