SULT1A1, sulfotransferase family 1A member 1, 6817

N. diseases: 122; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 Biomarker disease BEFREE <i>In vivo</i>, PST 3.1a reduced intersegmental vessel formation and vascularization of the subintestinal plexus in zebrafish embryos and also altered pathologic angiogenesis and glioblastoma progression <i>in vivo</i>. 30817178 2019
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.020 Biomarker disease BEFREE <i>In vivo</i>, PST 3.1a reduced intersegmental vessel formation and vascularization of the subintestinal plexus in zebrafish embryos and also altered pathologic angiogenesis and glioblastoma progression <i>in vivo</i>. 30817178 2019
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.020 Biomarker disease BEFREE <i>In vivo</i>, PST 3.1a reduced intersegmental vessel formation and vascularization of the subintestinal plexus in zebrafish embryos and also altered pathologic angiogenesis and glioblastoma progression <i>in vivo</i>. 30817178 2019
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.020 Biomarker disease BEFREE <i>In vivo</i>, PST 3.1a reduced intersegmental vessel formation and vascularization of the subintestinal plexus in zebrafish embryos and also altered pathologic angiogenesis and glioblastoma progression <i>in vivo</i>. 30817178 2019
CUI: C0851140
Disease: Carcinoma in situ of uterine cervix
Carcinoma in situ of uterine cervix 		0.010 Biomarker disease BEFREE 88.2% (60/68) of the histologically confirmed CIN 3 lesions and six out of nine (66.6%) CIN 2 lesions were positive PST+. 20129068 2009
CUI: C1320453
Disease: Cervical Squamous Cell Carcinoma In Situ
Cervical Squamous Cell Carcinoma In Situ 		0.010 Biomarker disease BEFREE 88.2% (60/68) of the histologically confirmed CIN 3 lesions and six out of nine (66.6%) CIN 2 lesions were positive PST+. 20129068 2009
CUI: C2987516
Disease: Cervix Intraepithelial Neoplasia Grade 3 AJCC v7
Cervix Intraepithelial Neoplasia Grade 3 AJCC v7 		0.010 Biomarker disease BEFREE 88.2% (60/68) of the histologically confirmed CIN 3 lesions and six out of nine (66.6%) CIN 2 lesions were positive PST+. 20129068 2009
CUI: C0349459
Disease: Cervical intraepithelial neoplasia grade 2
Cervical intraepithelial neoplasia grade 2 		0.010 Biomarker disease BEFREE 88.2% (60/68) of the histologically confirmed CIN 3 lesions and six out of nine (66.6%) CIN 2 lesions were positive PST+. 20129068 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 PosttranslationalModification disease BEFREE Breast cancer tissue showed a higher methylation rate of SULT1A1 than normal and benign tissue at both P1 (p=0.001) and P0 (p=0.006) promoters with statistical significance. 16328031 2006
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 PosttranslationalModification disease BEFREE Breast cancer tissue showed a higher methylation rate of SULT1A1 than normal and benign tissue at both P1 (p=0.001) and P0 (p=0.006) promoters with statistical significance. 16328031 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.070 GeneticVariation disease LHGDN Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study. 18365755 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 GeneticVariation disease BEFREE Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk. 11219777 2001
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 GeneticVariation disease BEFREE Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk. 11219777 2001
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 GeneticVariation disease BEFREE Sulfotransferase 1A1 (SULT1A1) polymorphism and breast cancer risk in Chinese women. 15093672 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 GeneticVariation disease BEFREE Sulfotransferase 1A1 (SULT1A1) polymorphism and breast cancer risk in Chinese women. 15093672 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 GeneticVariation disease BEFREE SULT1A1 genotype did not correlate with any prognostic or predictive markers associated with breast cancer. 16317586 2006
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 GeneticVariation disease BEFREE SULT1A1 genotype did not correlate with any prognostic or predictive markers associated with breast cancer. 16317586 2006
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE SULT1A1 genotypes were successfully detected using the PCR-RFLP assay in 60 primary brain tumor patients and 156 hospital-based healthy control individuals with no history of cancer or precancerous disorder. 17605044 2008
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 GeneticVariation group BEFREE SULT1A1 genotypes were successfully detected using the PCR-RFLP assay in 60 primary brain tumor patients and 156 hospital-based healthy control individuals with no history of cancer or precancerous disorder. 17605044 2008
CUI: C1292778
Disease: Chronic myeloproliferative disorder
Chronic myeloproliferative disorder 		0.010 Biomarker disease BEFREE SULT1A1*2 showed significant risk association with UADT-MPN (odds ratio (OR)=5.50, 95% confidence interval (CI): 1.09, 27.7). 18854828 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.030 GeneticVariation disease BEFREE Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese. 19126640 2009
CUI: C0238033
Disease: Carcinoma of Male Breast
Carcinoma of Male Breast 		0.020 GeneticVariation disease BEFREE SULT1A1 gene deletion was observed in 10 of the 72 MBCs (13.9%). 23711090 2013
CUI: C0242787
Disease: Malignant neoplasm of male breast
Malignant neoplasm of male breast 		0.020 GeneticVariation disease BEFREE SULT1A1 gene deletion was observed in 10 of the 72 MBCs (13.9%). 23711090 2013
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 GeneticVariation disease BEFREE SULT1A1 Arg213His didn't show any association with breast cancer, but the possible risk in Asian population needs further investigation. 25225888 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 GeneticVariation disease BEFREE SULT1A1 Arg213His didn't show any association with breast cancer, but the possible risk in Asian population needs further investigation. 25225888 2014