|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that the NF-κB, p38 MAPK, and PKC signal pathways are partially involved in the upregulation of KATP subunits Kir6.2/SUR1 expression induced by Aβ<sub>1-42</sub> cytotoxicity in neurons, which supports a potential theoretical basis of targeting these signal pathways in the treatment of AD.
|
30868916 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, Mrp8/14/TLR4/NF-κB activated by platelet-neutrophil interaction is an important inflammatory signaling pathway for AS pathogenesis.
|
30302814 |
2019 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, Mrp8/14/TLR4/NF-κB activated by platelet-neutrophil interaction is an important inflammatory signaling pathway for AS pathogenesis.
|
30302814 |
2019 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, the expression of SUR1 in human brain tumors has not been elucidated.
|
30079884 |
2019 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, the expression and role of SUR1 in cancer are unknown.
|
31341030 |
2019 |
|
Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SUR1 colocalized most reliably with the neuronal marker, NeuN, in glioblastoma, metastases, and posterior fossa ependymoma samples (p < 0.05).
|
30079884 |
2019 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma..
|
30079884 |
2019 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma..
|
30079884 |
2019 |
|
Meningitis, Pneumococcal
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results indicated that MRP8/14 augmented the inflammatory response in mice with pneumococcal meningitis and contributed to the development of disease, which was probably through NF-κB signalling pathway activation.
|
31049785 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
SUR1 expression was greater in supratentorial ependymoma compared to glioblastoma and metastases (p < 0.05) and greater in medulloblastoma compared to glioblastoma (p < 0.05).
|
30079884 |
2019 |
|
Neuralgia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Behavioral data from neuropathic mice indicate that local reductions in SUR1-subtype K<sub>ATP</sub> channel activity can exacerbate neuropathic pain symptoms.
|
31067750 |
2019 |
|
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results suggest that salivary CgA and MRP-8/14 could be related to the pathogenesis of periodontitis and diabetes.
|
31538150 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Similarly, MRP8, MRP14, and MRP8/14 were highly expressed in rat AAA model, while the administrations of antibodies of MRPs significantly reversed the improvement expressions of MRP8 and MRP14.
|
31351425 |
2019 |
|
Chronic Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
MRP-8/14 values in saliva from chronic periodontitis patients and diabetic patients with chronic periodontitis was significantly higher than that in the control group.
|
31538150 |
2019 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma..
|
30079884 |
2019 |
|
Childhood Supratentorial Ependymoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SUR1 expression was greater in supratentorial ependymoma compared to glioblastoma and metastases (p < 0.05) and greater in medulloblastoma compared to glioblastoma (p < 0.05).
|
30079884 |
2019 |
|
Adult Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SUR1 colocalized most reliably with the neuronal marker, NeuN, in glioblastoma, metastases, and posterior fossa ependymoma samples (p < 0.05).
|
30079884 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma..
|
30079884 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma..
|
30079884 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma..
|
30079884 |
2019 |
|
Cerebral metastasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of SUR1 with glyburide decreases edema and neuroinflammation by countering cytotoxic edema and apoptosis in rodent models of subarachnoid hemorrhage, stroke, trauma, and cerebral metastases.
|
30079884 |
2019 |
|
Newly Diagnosed Childhood Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SUR1 colocalized most reliably with the neuronal marker, NeuN, in glioblastoma, metastases, and posterior fossa ependymoma samples (p < 0.05).
|
30079884 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, the expression and role of SUR1 in cancer are unknown.
|
31341030 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma..
|
30079884 |
2019 |
|
Childhood Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SUR1 colocalized most reliably with the neuronal marker, NeuN, in glioblastoma, metastases, and posterior fossa ependymoma samples (p < 0.05).
|
30079884 |
2019 |