|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases.
|
18460022 |
2008 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the SYT-SSX fusion type is not a significant prognostic factor unlike tumor size, followed by histological grade for patients with localized synovial sarcoma in Japan.
|
18202796 |
2008 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The presence of a specific diagnostic t(X;18) translocation leading to expression of the unique SYT-SSX fusion protein in effectively all cases of synovial sarcoma suggests a role in the etiology.
|
18563504 |
2008 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis detected a fusion gene transcript of synovial sarcoma translocation (SYT) gene from chromosome 18 and synovial sarcoma X chromosome breakpoint 1 (SSX1) gene, which is believed to pathognomonic for synovial sarcoma of joint origin.
|
17197895 |
2007 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Real-time RT-PCR assays specific for Ewing's sarcoma (EWS-FLI1, EWS-ERG, EWS-ETV1, EWS-ETV4, and EWS-FEV), synovial sarcoma (SYT-SSX1 and SYT-SSX2), and rhabdomyosarcoma (PAX3-FKHR and PAX7-FKHR) were tested across the samples.
|
17334332 |
2007 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although SYT-SSX fusion proteins appear to trigger synovial sarcoma development, little is known about the downstream targets of SYT-SSX.
|
17101797 |
2007 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We report here a mouse model of synovial sarcoma based on conditional expression of the human SYT-SSX2.
|
17418413 |
2007 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis by reverse transcriptase polymerase chain reaction failed to identify the SYT-SSX1 or SYT-SSX2 fusion transcripts characteristic of synovial sarcoma.
|
17707262 |
2007 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The synovial sarcoma-associated protein SS18 (also known as SYT or SSXT) is thought to act as a transcriptional co-activator.
|
16926188 |
2006 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we introduce the application of RT in situ PCR to detect a hybrid, SYT-SSX messenger RNA in synovial sarcoma.
|
16861763 |
2006 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SYT-SSX2 is the fusion product of the chromosomal translocation, t(X;18)(p11.2;q11.2), which occurs in synovial sarcoma, a soft tissue tumor.
|
16462762 |
2006 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The definitive diagnosis of synovial sarcoma was made following molecular genetic studies, which demonstrated a fusion product incorporating the genes SYT and SSX1.
|
16220269 |
2006 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The striking spontaneous mesenchymal to epithelial differentiation in this cancer is reminiscent of a developmental switch, but the only clue to its mechanistic basis has been the observation that most cases of synovial sarcoma with glandular epithelial differentiation (GED) contain SYT-SSX1 instead of SYT-SSX2.
|
16849535 |
2006 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report a case of synovial sarcoma with a novel form of the SYT-SSX2 fusion transcript, in which 75 bases were inserted at the common fusion junction.
|
16682293 |
2006 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report a cooperative study from the French Sarcoma Group and the Mesopath Group on 40 t(X;18)(SYT-SSX)-positive primary intrathoracic SS.
|
15725802 |
2005 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Induction of p21(WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1.
|
16103879 |
2005 |
|
Childhood Synovial Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The SYT-SSX fusion protein that results from the X,18 translocation is an appealing target, as are the proteins overexpressed in synovial sarcoma: bcl-2, EGFR, and HER-2/neu.
|
15838395 |
2005 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that both histological subtypes of synovial sarcoma were SYT-SSX positive.
|
15735574 |
2005 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the specific chromosomal translocation and fusion gene SYT-SSX in synovial sarcoma (SS) has been identified, the molecular mechanism of its tumorigenesis is largely unknown.
|
16556060 |
2005 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of the synovial sarcoma-associated t(X;18) or SYT-SSX fusion transcripts may be necessary to confirm the diagnosis of SS in difficult cases.
|
15163010 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of our study was to assess microinvasion in a case of synovial sarcoma by means of the reverse transcriptase polymerase chain reaction (RT-PCR) for detecting SYT-SSX fusion transcripts.
|
15045545 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SYT-SSX fusion genes in synovial sarcoma of the thorax.
|
15140553 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings indicate possible geographical differences in the frequency of two SYT-SSX fusion transcripts in patients with synovial sarcoma.
|
15350633 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To assess the prognostic value of SYT-SSX fusion type, in comparison with other factors, in a population of 165 patients with synovial sarcoma (SS).
|
15364967 |
2004 |
|
Childhood Synovial Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SYT-SSX2 variant of primary pulmonary synovial sarcoma with focal expression of CD117 (c-Kit) protein and a poor clinical outcome.
|
12683902 |
2003 |