Alcoholic Intoxication, Chronic
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Genetic deletion or antagonism of the neurokinin 1 receptor (NK1R) decreases alcohol intake, alcohol reward, and stress-induced alcohol relapse in rodents, while TACR1 variation is associated with alcoholism in humans.
|
23419547 |
2013 |
Alcoholic Intoxication, Chronic
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
Each of the 5 SNPs in the TACR1 gene that was significantly related to AD severity in the SAGE data set and/or the BOLD response to the craving task is near the 3' or 5' areas of the gene and may therefore be near mutations with potential functional significance.
|
23078527 |
2013 |
Alcoholic Intoxication, Chronic
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Each of the 5 SNPs in the TACR1 gene that was significantly related to AD severity in the SAGE data set and/or the BOLD response to the craving task is near the 3' or 5' areas of the gene and may therefore be near mutations with potential functional significance.
|
23078527 |
2013 |
Alcoholic Intoxication, Chronic
|
0.550 |
Biomarker
|
disease |
BEFREE |
Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism.
|
18276852 |
2008 |
Alcoholic Intoxication, Chronic
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
To further elucidate the role of TACR1 in affective disorders, rs3771829 was genotyped in a second BPAD sample of 593 subjects (UCL2), in 997 subjects with ADS, and a subsample of 143 individuals diagnosed with BPAD and comorbid alcohol dependence (BPALC). rs3771829 was associated with BPAD (UCL1 and UCL2 combined: P = 2.0 × 10(-3)), ADS (P = 2.0 × 10(-3)) and BPALC (P = 6.0 × 10(-4)) compared with controls screened for the absence of mental illness and alcohol dependence.
|
24817687 |
2014 |
Alcoholic Intoxication, Chronic
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |
Alcoholic Intoxication, Chronic
|
0.550 |
Biomarker
|
disease |
CTD_human |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |
Alcoholic Intoxication, Chronic
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
Taken together, we conclude that polymorphisms of NK1R are significantly associated with the development of AD in Caucasian individuals.
|
19553914 |
2009 |
Alcoholic Intoxication, Chronic
|
0.550 |
Biomarker
|
disease |
PSYGENET |
After binding to the neurokinin-1 (NK-1) receptor, SP regulates many pathophysiological functions in the central nervous system, such as emotional behavior, stress, depression, anxiety, emesis, vomiting, migraine, alcohol addiction, seizures and neurodegeneration.
|
24705689 |
2014 |
Alcoholic Intoxication, Chronic
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |
Alcoholic Intoxication, Chronic
|
0.550 |
Biomarker
|
disease |
PSYGENET |
The association with TACR1 and BPAD, ADS, and ADHD suggests a shared molecular pathophysiology between these affective disorders.
|
24817687 |
2014 |
Bipolar Disorder
|
0.520 |
GeneticVariation
|
disease |
BEFREE |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |
Bipolar Disorder
|
0.520 |
Biomarker
|
disease |
PSYGENET |
The association with TACR1 and BPAD, ADS, and ADHD suggests a shared molecular pathophysiology between these affective disorders.
|
24817687 |
2014 |
Bipolar Disorder
|
0.520 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder.
|
19415819 |
2009 |
Bipolar Disorder
|
0.520 |
Biomarker
|
disease |
CTD_human |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |
Bipolar Disorder
|
0.520 |
Biomarker
|
disease |
BEFREE |
The association with TACR1 and BPAD, ADS, and ADHD suggests a shared molecular pathophysiology between these affective disorders.
|
24817687 |
2014 |
Bipolar Disorder
|
0.520 |
Biomarker
|
disease |
PSYGENET |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |
Attention Deficit Disorder
|
0.500 |
Biomarker
|
disease |
MGD |
Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme.
|
9748515 |
1998 |
Attention Deficit Disorder
|
0.500 |
Biomarker
|
disease |
CTD_human |
NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD.
|
19204064 |
2010 |
Attention Deficit Disorder
|
0.500 |
Biomarker
|
disease |
MGD |
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.
|
11433347 |
2001 |
Neurogenic Inflammation
|
0.500 |
Biomarker
|
disease |
CTD_human |
Proliferation of sensory C-fibers and subsequent neurogenic inflammation in rat airway induced by inhaled lipopolysaccharide.
|
21570423 |
2011 |
Neurogenic Inflammation
|
0.500 |
Biomarker
|
disease |
CTD_human |
Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation.
|
17257769 |
2007 |
Neurogenic Inflammation
|
0.500 |
Biomarker
|
disease |
RGD |
These findings suggest that SP acts via the NK-1 receptor to provoke neurogenic inflammation, oxidative stress, and ICAM-1 expression after OSE in rats.
|
18326823 |
2008 |
Attention deficit hyperactivity disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
DNA sequencing in selected cases of BPAD and ADHD who had inherited TACR1-susceptibility haplotypes identified 19 SNPs in the promoter region, 5' UTR, exons, intron/exon junctions and 3' UTR of TACR1 that could increase vulnerability to BPAD, ADS, ADHD, and BPALC.
|
24817687 |
2014 |
Attention deficit hyperactivity disorder
|
0.330 |
Biomarker
|
disease |
CTD_human |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |