Acute cholecystitis without calculus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
AAC: Acute acalculous cholecystitis; T-ALL: T-cell acute lymphoblastic leukemia; TPN: Total parenteral nutrition.
|
28085529 |
2017 |
Acute diarrhea
|
0.010 |
Biomarker
|
disease |
BEFREE |
The antidiarrheal effect of α-TPN in the treatment of acute diarrhea and enteropooling induced by castor oil or PGE<sub>2</sub> in Swiss mice pretreated orally with saline (NaCl 0.9%), Loperamide (5 mg/kg) and α-TPN (6.25, 12.5, 25 and 50 mg/kg) was analyzed.
|
30540974 |
2019 |
Acute GVH disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hepatobiliary dysfunction was less frequent (12%) but carried a poor prognosis. aGVHD grade II-IV (OR 2.7, p = 0.02) and long-term TPN (OR 3.25, p = 0.01) increased the risk.
|
26518451 |
2016 |
Anastomosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients who underwent duodenocolonic anastomosis received smaller TPN volume (33.8 vs 49.8 mL/kg).
|
28755968 |
2017 |
Ankylosing spondylitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we conducted classical molecular dynamics simulations of two HLA alleles, the ankylosing spondylitis (AS) associated/tapasin-dependent HLA-B*27:05 and nondisease-associated/tapasin-independent HLA-B*27:09, both in peptide-free forms as well as complex with four different peptides ligands.
|
28278760 |
2018 |
Ankylosing spondylitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Thus, except for the differential effects of tapasin on surface expression, the tapasin, TAP, and immunoproteasome dependency of B*2704 for maturation, surface expression, and T cell recognition are similar to B*2705, indicating that basic immunological features are shared by the two major HLA-B27 allotypes associated to ankylosing spondylitis in human populations.
|
17082617 |
2006 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
To deliver personalized RNA-based-therapy targeting oncogenic miRNAs that form part of this common PDAC miRNA over-expression signature, we packaged antimiR oligonucleotides against one of these miRNAs in tumor-penetrating nanocomplexes (TPN) targeting cell surface proteins on PDAC tumors.<b>Results:</b> As a validation for our pre-clinical strategy, the therapeutic potential of one of our nano-drugs, TPN-21, was first shown to decrease tumor cell growth and survival in PDO avatars for individual patients, then in their PDX avatars.<b>Conclusions:</b> This general approach appears suitable for co-clinical validation of personalized RNA medicine and paves the way to prospectively identify patients with eligible miRNA profiles for personalized RNA-based therapy.<i></i>.
|
29330203 |
2018 |
Aspirin exacerbated respiratory disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis showed that the minor allele frequencies of TAPBP rs2071888 C>G (Thr260Arg) on exon 4 (P>0.05), which was in absolute linkage disequilibrium with rs1059288 T>C on 3'UTR, were significantly higher in the AERD group than in the aspirin-tolerant asthma group, and the P values remained significant after multiple comparisons (Pcorr=0.006, odds ratio: 1.37, 95% confidence interval: 1.11-1.69, additive model; Pcorr=0.009, odds ratio: 1.52, 95% confidence interval: 1.14-2.03, dominant model).
|
23736108 |
2013 |
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis showed that the minor allele frequencies of TAPBP rs2071888 C>G (Thr260Arg) on exon 4 (P>0.05), which was in absolute linkage disequilibrium with rs1059288 T>C on 3'UTR, were significantly higher in the AERD group than in the aspirin-tolerant asthma group, and the P values remained significant after multiple comparisons (Pcorr=0.006, odds ratio: 1.37, 95% confidence interval: 1.11-1.69, additive model; Pcorr=0.009, odds ratio: 1.52, 95% confidence interval: 1.14-2.03, dominant model).
|
23736108 |
2013 |
Bare Lymphocyte Syndrome, Type I
|
0.610 |
Biomarker
|
disease |
BEFREE |
These results suggest that tapasin deficiency is another cause of type I BLS.
|
12149238 |
2002 |
Bare Lymphocyte Syndrome, Type I
|
0.610 |
GermlineCausalMutation
|
disease |
ORPHANET |
A subject with a novel type I bare lymphocyte syndrome has tapasin deficiency due to deletion of 4 exons by Alu-mediated recombination.
|
12149238 |
2002 |
Bare Lymphocyte Syndrome, Type I
|
0.610 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
A subject with a novel type I bare lymphocyte syndrome has tapasin deficiency due to deletion of 4 exons by Alu-mediated recombination.
|
12149238 |
2002 |
Bare Lymphocyte Syndrome, Type I
|
0.610 |
Biomarker
|
disease |
CTD_human |
|
|
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
Bronchiectasis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Bronchiolitis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Brooke-Spiegler syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The villus height and crypt depth of the ileum in the SBS/TPN/ghrelin group were significantly higher than in the SBS/TPN group.
|
29966680 |
2018 |
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Metastatic human carcinomas often express low levels of the antigen-processing components Tapasin and TAP and display few functional surface MHC class I molecules.
|
18316574 |
2008 |
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To test our hypothesis, a nonreplicating adenovirus vector encoding human Tpn (AdhTpn) was constructed to restore Tpn expression in vitro and in vivo in a murine lung carcinoma cell line (CMT.64) that is characterized by down-regulation of surface MHC class I due to deficiency in antigen-processing components.
|
18316574 |
2008 |
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lack of HLA-class I antigens in human neuroblastoma cells: analysis of its relationship to TAP and tapasin expression.
|
11260505 |
2001 |
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirty-five single-nucleotide polymorphisms (SNPs) in 5 genes (LMP2, TAP1, LMP7, TAP2, and Tapasin) were investigated for association with susceptibility to HPV16-associated cervical cancer.
|
18248301 |
2008 |
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thirty-five single-nucleotide polymorphisms (SNPs) in 5 genes (LMP2, TAP1, LMP7, TAP2, and Tapasin) were investigated for association with susceptibility to HPV16-associated cervical cancer.
|
18248301 |
2008 |
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lack of HLA-class I antigens in human neuroblastoma cells: analysis of its relationship to TAP and tapasin expression.
|
11260505 |
2001 |
Cholera
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results suggest an anti-diarrheal activity of α-TPN due to its anticholinergic action, ability to block PGE<sub>2</sub> and GM1 receptors and interaction with cholera toxin in secretory diarrhea, making it a promising candidate drug for the treatment of diarrheal diseases.
|
30540974 |
2019 |