|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
Coronary heart disease was more common in MODY3 than in IDDM (16 vs 4.5%; p < 0.02) but less common than in the older NIDDM patients (33.3%; p < 0.02).
|
9562352 |
1998 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to estimate the prevalence of MODY 3 in antiislet autoantibody negative patients with type 1 diabetes.
|
10634407 |
2000 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel frameshift mutation (142delG) in the TCF1 gene in a family with a strong family history of type 1 diabetes and examined the functional properties of the mutant HNF 1alpha.
|
11668618 |
2001 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the prevalence of mutations in the hepatocyte nuclear factor (HNF)-1alpha gene (TCF1) in a large group of Japanese patients with early-onset non-Type I (insulin-dependent) diabetes mellitus.
|
12488961 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HNF-1alpha gene mutations (MODY3) present with marked hyperglycemia in lean young adults and may, therefore, be mistaken for type 1 diabetes, with implications for individual treatment and risk of diabetes in other family members.
|
12547858 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Twenty-two families with clinical MODY, 15 families with suspected MODY, and one family with type 1 diabetes multiplex harbored HNF-1 alpha mutations.
|
12574234 |
2003 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The coexistence of type 1 diabetes autoimmunity and a mutation in the gene responsible for MODY3 in this overweight patient is intriguing and might explain the early onset of progressive insulinopenia compared with the later age of diabetes onset of the earlier generation in the family.
|
18221440 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
Pancreatic volume index was reduced in subjects with HNF1A-MODY (34.5 ml/m2; P < 0.02) and type 1 diabetes (21.4 ml/m2; P < 0.001) as compared with nondiabetic controls (45.7 ml/m2), and was reduced in subjects with diabetes in combination with fecal elastase deficiency (P = 0.03).
|
18593771 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
UCPCR was lower in type 1 diabetes than HNF1A/4A MODY (median [interquartile range]) (<0.02 nmol/mmol [<0.02 to <0.02] vs. 1.72 nmol/mmol [0.98-2.90]; P < 0.0001).
|
21270186 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
We measured plasma GAD and IA-2 antibodies in 508 patients with the most common forms of maturity-onset diabetes of the young (GCK: n = 227; HNF1A: n = 229; HNF4A: n = 52) and 98 patients with newly diagnosed Type 1 diabetes (diagnosed < 6 months).
|
21395678 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
By contrast, HNF1A mutations lead to a diabetes form that in severity, treatment and complication risk resembles Type 1 diabetes, although these patients may experience a good effect of sulfonylurea treatment.
|
21463240 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
Clinical applicability and cut-off value were evaluated in all available patients with GCK-MODY (n = 148), hepatocyte nuclear factor 1-alpha-MODY (HNF1A MODY) (n = 37) or type 1 diabetes (n = 221).
|
21521320 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
hs-CRP was lower in HNF1A-MODY (median [IQR] 0.3 [0.1-0.6] mg/L) than type 2 diabetes (1.40 [0.60-3.45] mg/L; P < 0.001) and type 1 diabetes (1.10 [0.50-1.85] mg/L; P < 0.001), HNF4A-MODY (1.45 [0.46-2.88] mg/L; P < 0.001), GCK-MODY (0.60 [0.30-1.80] mg/L; P < 0.001), and HNF1B-MODY (0.60 [0.10-2.8] mg/L; P = 0.07). hs-CRP discriminated HNF1A-MODY from type 2 diabetes with hs-CRP <0.75 mg/L showing 79% sensitivity and 70% specificity (receiver operating characteristic area under the curve = 0.84).
|
21700917 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
We initially examined 51 HNF1A-MODY patients, 56 subjects with type 1 diabetes (T1DM), 39 with type 2 diabetes (T2DM) and 43 non-diabetic individuals (ND) from Poland.
|
22350134 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein M can discriminate HNF1A-MODY from Type 1 diabetes.
|
23157689 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
This is the first report ever to describe the familial manifestation of T1DM autoimmunity in nonobese HNF1A-MODY subjects and the presence of islet antigen-2 (IA-2) antibodies in MODY subjects.
|
23548576 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Small, potentially atherogenic HDL content differed significantly with the GCK-MODY group showing concentrations of that subfraction from control (p = 0.0096), T1DM (p = 0.0193) and HNF1A-MODY (p = 0.0057) groups.
|
24549415 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
For type 1 diabetes, a strong association was seen for MTNR1B (rs10830963, p = 3.2 × 10(-6)) and HNF1A (rs2650000, p = 0.0012).
|
24906951 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A high frequency of MD from mutations in GCK/HNF1α may be identified among pediatric diabetic patients originally considered to have T1D by performing genetic testing on those patients with multiple clinical risk factors for MD.
|
25082184 |
2015 |