|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
Biomarker
|
disease |
BEFREE |
Subjects which were neither MODY2 nor MODY3 (MODY-X) had a higher fasting glucose than subjects in the other groups.
|
10754480 |
2000 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Recently, hepatocyte nuclear factor-1alpha(HNF-1alpha, which is encoded by the TCF1 gene) mutations were reported in a subset of patients with maturity onset diabetes of the young (MODY3).
|
9840451 |
1998 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Carriers of both GCK and HNF1A mutations manifested a typical MODY 3 phenotype and showed that the presence of a second mutation in the GCK gene apparently did not modify the clinical outcome, at least at the time of this study.
|
23009393 |
2013 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
Biomarker
|
disease |
BEFREE |
Here, we profiled metabolites in serum from patients with MODY1 (HNF4A), MODY2 (GCK), MODY3 (HNF1A), and type 2 diabetes and from healthy individuals to characterize metabolic perturbations caused by specific mutations.
|
23139355 |
2013 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
Biomarker
|
disease |
BEFREE |
Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)?
|
18513302 |
2008 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The described family demonstrates a novel HNF1A mutation associated with both benign and malignant primary liver cell tumours and MODY3.
|
23707370 |
2013 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Human mutations in its prototypical member HNF1A cause maturity-onset diabetes of the young (MODY) type 3.
|
29109103 |
2017 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
Biomarker
|
disease |
BEFREE |
Seventy-one DPV patients were labelled as HNF1A-MODY (MODY3).
|
21224407 |
2011 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the transcription factor hepatocyte nuclear factor-1alpha (HNF-1alpha; gene symbol TCF1) cause maturity-onset diabetes of the young type 3 (MODY3), a form of diabetes mellitus characterized by autosomal dominant inheritance, early onset, and pancreatic beta-cell dysfunction.
|
11668618 |
2001 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
In humans mutations in the HNF1 gene are responsible for one form of maturity onset diabetes of the young (MODY3).
|
12530534 |
2002 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The reverse tetracycline-dependent transactivator system was employed in insulinoma INS-1 cells to achieve controlled inducible expression of hepatocyte nuclear factor-1 alpha (HNF1 alpha)-P291fsinsC, the most common mutation associated with subtype 3 of maturity-onset diabetes of the young (MODY3).
|
10944108 |
2000 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Divergent phenotypes in siblings with identical novel mutations in the HNF-1α gene leading to maturity onset diabetes of the young type 3.
|
27142837 |
2016 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We developed a transgenic cloned pig (founder, male) carrying a mutant gene, i.e., human HNF-1α (P291fsinsC), which is responsible for maturity-onset diabetes of the young type 3.
|
28254450 |
2017 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
Biomarker
|
disease |
BEFREE |
Germline mutations in hepatocyte nuclear factor 1alpha (TCF1/HNF-1alpha) are associated with maturity-onset diabetes of the young type 3 (MODY3), and somatic biallelic inactivations of the gene are found in hepatocellular adenomas and liver adenomatosis.
|
14598263 |
2003 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
A Case of Maturity Onset Diabetes of the Young (MODY3) in a Family with a Novel HNF1A Gene Mutation in Five Generations.
|
29222740 |
2018 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Hepatocyte nuclear factor 1 alpha (HNF1A) mutations cause maturity-onset diabetes of the young (MODY) type 3.
|
23616187 |
2013 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Mutations in HNF1α gene are frequently associated with maturity-onset diabetes of the young type 3 (MODY3) and hepatocellular adenomas.
|
29101032 |
2018 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
Biomarker
|
disease |
BEFREE |
Although the HNF-1alpha-null mice have an average life span of 1 year, the severe liver phenotype has thwarted attempts to study the pathogenesis of maturity-onset diabetes of the young type 3 (MODY3) and to examine therapeutic strategies for diabetes prevention and treatment in these mice.
|
12529398 |
2003 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous germline mutations of TCF1 have been identified in individuals affected with maturity-onset diabetes of the young type 3 (MODY3; ref.3).
|
12355088 |
2002 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We have examined 10 unrelated Caucasian families in which MODY/NIDDM co-segregated with markers for MODY3 for mutations in the HNF-1alpha gene (TCF1).
|
9097962 |
1997 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation.
|
29597128 |
2018 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Here we show that subjects with the MODY3-form of NIDDM have mutations in the gene encoding hepatocyte nuclear factor-1alpha (HNF-1alpha, which is encoded by the gene TCF1).
|
8945470 |
1996 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
Biomarker
|
disease |
BEFREE |
HNF1A-MODY (MODY3) is a common subtype of autosomal dominant diabetes.
|
21648289 |
2011 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Maturity-onset diabetes of the young type 3 (MODY3) is caused by heterozygous mutation in the HNF1A gene.
|
22672869 |
2012 |
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
A spectrum of HNF1A somatic mutations significantly differed from the germline changes in MODY3.
|
20393147 |
2010 |