|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The result of this study provides evidence that variants in the HNF1beta region contribute to susceptibility to type 2 diabetes in the Chinese population.
|
19168595 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
GWASDB |
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
|
22325160 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Islet ATAC-seq peaks overlap with 13 SNPs associated with T2D (e.g. rs7903146, rs2237897, rs757209, rs11708067 and rs878521 near TCF7L2, KCNQ1, HNF1B, ADCY5 and GCK, respectively) and with additional 67 SNPs in LD with known T2D SNPs (e.g.
|
31123324 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
The results confirm that the genetic variations in the HNF-1 beta gene would be a very uncommon cause of progressive nephropathy in patients with type 2 diabetes mellitus.
|
12012276 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
|
30718926 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The results confirm that the genetic variations in the HNF-1 beta gene would be a very uncommon cause of progressive nephropathy in patients with type 2 diabetes mellitus.
|
12012276 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
|
21874001 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
|
22961080 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
The subject with the R276X mutation had MODY5 misdiagnosed as common type 2 diabetes.
|
12161522 |
2002 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We observed consistent and significant associations of IGF2BP2, WFS1, CDKAL1, SLC30A8, CDKN2A/B, HHEX, TCF7L2 and KCNQ1 (8.5×10(-18)<P<8.5×10(-3)), as well as nominal associations of NOTCH2, JAZF1, KCNJ11 and HNF1B (0.05<P<0.1) with T2D risk, which yielded odds ratios ranging from 1.07 to 2.09.
|
24376643 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Nominal interactions were observed for sleep duration and PPARG rs1801282, CRY2 rs7943320 and HNF1B rs4430796 in influencing risk of type 2 diabetes (p < 0.05).
|
24280871 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers.
|
25378557 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in hepatocyte nuclear factor-1β gene result in a multisystemic syndrome where a monogenic form of diabetes (maturity-onset diabetes of young type 5; MODY 5) and renal anomalies, usually bilateral multiple cysts are the most characteristic findings.
|
29574432 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Not only did an association between WFS1-rs6446482 and early-onset T2D exist in the subgroup analysis, but TCF2-rs7501939 and WFS1-rs6446482 were also confirmed to confer risk for T2D in this meta-analysis.
|
20509872 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
MODY is genetically heterogeneous with five different genes identified to date: hepatocyte nuclear factor-4 alpha (HNF-4 alpha) [MODY1]; glucokinase [MODY2]; hepatocyte nuclear factor-1 alpha (HNF-1 alpha) [MODY3]; insulin promoter factor-1 (IPF-1) [MODY4]; and hepatocyte nuclear factor-1 beta (HNF-1 beta) [MODY5].
|
11058894 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Studies of the variability of the hepatocyte nuclear factor-1beta (HNF-1beta / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and beta-cell function.
|
11668623 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer.
|
18696045 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that as in white patients, MODY resulting from mutations in the HNF-1 alpha, HNF-1 beta, and HNF-4 alpha genes in Japanese patients may be a severe disease similar to classic type 2 diabetes.
|
9839108 |
1998 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies revealed a heterozygous mutation (S148L) of the HNF1B gene, compatible with an HNF1B-MODY phenotype (MODY5).
|
21767339 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.
|
17327436 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
To investigate whether mutations in HNF-1 are implicated in the pathogenesis of MODY or late-onset diabetes with and without nephropathy in Danish Caucasians we examined the HNF-1beta (TCF2) and the dimerization cofactor of HNF-1 (DCoH, PCBD) genes for mutations in 11 MODY probands, 28 type 2 diabetic patients with nephropathy, and 46 type 2 diabetic patients with an impaired beta-cell function by combined single-strand conformation polymorphism (SSCP) and heteroduplex analysis.
|
11668623 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
|
21499250 |
2011 |